関: myoepithelia、myoepithelial

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/20 18:57:40」(JST)

wiki en

Myoepithelial cells (sometimes referred to as myoepithelium) are cells usually found in glandular epithelium as a thin layer above the basement membrane but generally beneath the luminal cells. These may be positive for alpha smooth muscle actin and can contract and expel the secretions of exocrine glands. They are found in the sweat glands, mammary glands, lacrimal glands, and salivary glands. Myoepithelial cells in these cases constitute the basal cell layer of an epithelium that harbors the epithelial progenitor. In the case of wound healing, myoepithelial cells reactively proliferate. Presence of myoepithelial cells in a hyperplastic tissue proves the benignity of the gland and, when absent, indicates cancer. Only rare cancers like adenoid cystic carcinomas contains myoepithelial cells as one of the malignant components.

It can be found in endoderm or ectoderm.^[1]

MarkersEdit

Myoepithelial cells are true epithelial cells positive for keratins, not to be confused with myofibroblasts which are true mesenchymal cells positive for vimentin. These cells are generally positive for alpha smooth muscle actin (αSMA), cytokeratin 5/6 and other high molecular weight cytokeratins, p63 and caldesmon. Myoepithelial cells are stellate in shape and are also known as basket cells. They lie between the basement membrane and glandular epithelium. Each cell consists of a cell body from which 4-8 processes radiate and embrace the secretory unit. Myoepithelial cells have contractile functions. They help in expelling secretions from the lumen of secretory units and facilitate the movement of saliva in salivary ducts.

ReferencesEdit

^ Jules J. Berman (2009). Neoplasms: principles of development and diversity. Jones & Bartlett Learning. pp. 207–. ISBN 978-0-7637-5570-6. Retrieved 16 April 2010.

External linksEdit

Anatomy Atlases - Microscopic Anatomy, plate 07.141 - "Axillary Sweat Gland: Myoepithelium"
Histology image: 43_13 at the University of Oklahoma Health Sciences Center - "thick skin"
Histology at KUMC glands-glands09 "Simple Tubular Coiled"
Physiology: 6/6ch4/s6ch4_4 - Essentials of Human Physiology

This anatomy article is a stub. You can help Wikipedia by expanding it.

English Journal

Myoepithelial Cell Differentiation Markers in Ductal Carcinoma in Situ Progression.

Russell TD1, Jindal S2, Agunbiade S1, Gao D3, Troxell M4, Borges VF5, Schedin P6.
The American journal of pathology.Am J Pathol.2015 Sep 4. pii: S0002-9440(15)00430-7. doi: 10.1016/j.ajpath.2015.07.004. [Epub ahead of print]
We describe a preclinical model that investigates progression of early-stage ductal carcinoma in situ (DCIS) and report that compromised myoepithelial cell differentiation occurs before transition to invasive disease. Human breast cancer DCIS.com cells were delivered into the mouse mammary teat by i
PMID 26343330

A pathological study of the salivary glands of rabid dogs in the Philippines.

Boonsriroj H1, Manalo DL, Kimitsuki K, Sihmatsu T, Shiwa N, Shinozaki H, Takahashi Y, Tanaka N, Inoue S, Park CH.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science.J Vet Med Sci.2015 Aug 14. [Epub ahead of print]
Rabies is a zoonotic disease caused by the rabies virus. While the salivary glands are important as exit and propagation sites for the rabies virus, the mechanisms of rabies excretion remain unclear. Here, we investigated the histopathology of the salivary glands of rabid dogs and analyzed the mecha
PMID 26278996

Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk.

Rajaram RD1, Buric D1, Caikovski M1, Ayyanan A1, Rougemont J2, Shan J3, Vainio SJ3, Yalcin-Ozuysal O4, Brisken C5.
The EMBO journal.EMBO J.2015 Mar 4;34(5):641-52. doi: 10.15252/embj.201490434. Epub 2015 Jan 20.
Ovarian hormones increase breast cancer risk by poorly understood mechanisms. We assess the role of progesterone on global stem cell function by serially transplanting mouse mammary epithelia. Progesterone receptor (PR) deletion severely reduces the regeneration capacity of the mammary epithelium. T
PMID 25603931

Japanese Journal

A pathological study of the salivary glands of rabid dogs in the Philippines

BOONSRIROJ Hassadin,MANALO Daria Llenaresas,KIMITSUKI Kazunori,SIHMATSU Taichi,SHIWA Nozomi,SHINOZAKI Harumi,TAKAHASHI Yurika,TANAKA Naoto,INOUE Satoshi,PARK Chun-Ho
Journal of Veterinary Medical Science advpub(0), 2015
… Viral antigens were detected in the mucous acinar epithelium, ganglion neurons and myoepithelium. … In the parotid gland, the acinar cells, myoepithelium and ductal epithelium all tested negative. … These findings confirmed the path through which the rabies virus descends along the facial nerve after proliferation in the brain to reach the ganglion neurons of the mandibular gland, subsequently traveling to the acinar epithelium via the salivary gland myoepithelium. …
NAID 130005091947

嚢胞形成を伴った乳腺悪性腺筋上皮腫の1例

佐藤達郎,安井章裕,青野景也,林祐次,原一夫
日本臨床外科学会雑誌 72(10), 2501-2506, 2011
症例は74歳，女性．主訴は右乳房C領域に3×3cmの腫瘤．マンモグラフィーでは右外上に中心が低濃度の局所非対称性陰影（FAD）を認め，カテゴリー3，超音波検査では類円形，嚢胞状で内部不均一な腫瘤を認めた．穿刺細胞診では乳癌疑い．針生検組織診ではinvasive ductal carcinoma，scirrhousの診断を得た．右乳房切除術および腋窩郭清を行った．病理組織学的には大きな嚢胞壁から周囲 …
NAID 130004696487

乳腺管状癌の臨床細胞学的検討

林諭史,横山恵,石川文秋,山崎知文,立野正敏,小林博也
日本臨床細胞学会雑誌 49(5), 337-341, 2010-09-22
目的 : まれな乳腺管状癌の細胞学的特徴について明らかにする.方法 : 当科で経験した乳腺管状癌 15 例の臨床像, 組織像, 細胞像を検討した.成績 : 乳腺管状癌は臨床的に低悪性度で予後良好な組織型であった. 細胞診上の特徴は, 1) 細胞採取量が多い, 2) 筋上皮細胞の混在が少ない, 3) 核小体が不明瞭, 4) 管状構造, 弾性物質がみられる, であった. 以上の所見を認めた場合, 管状 …
NAID 10026670140