English Journal

A Novel Factor, Tmem176b, Induced by Activin-like Kinase 2 Signal Promotes the Differentiation of Myoblasts into Osteoblasts.

Yano M, Kawao N, Tamura Y, Okada K, Kaji H.SourceDepartment of Physiology and Regenerative Medicine, Kinki University Faculty of Medicine, Ohnohigashi, Osakasayama, Japan.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.Exp Clin Endocrinol Diabetes.2013 Oct 1. [Epub ahead of print]
Previous studies have suggested some interactions between muscle tissues and bone metabolism. The constitutively activating mutation (R206H) of the BMP type I receptor, activin-like-kinase 2 (ALK2), causes fibrodysplasia ossificans progressiva (FOP), which is characterized by extensive ossifications
PMID 24085390

Arecoline inhibits and destabilizes agrin-induced acetylcholine receptor cluster formation in C2C12 myotubes.

Chang YF, Liu TY, Liu ST.SourceDepartment of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address: m795003@kmu.edu.tw.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.Food Chem Toxicol.2013 Oct;60:391-6. doi: 10.1016/j.fct.2013.07.079. Epub 2013 Aug 8.
Areca nut (Areca catechu) is chewed as a medical and psychoactive food by roughly 10% of the world population. Areca nut chewing may lead to low birth weight, premature delivery and impaired muscle development. Our previous study showed that arecoline, a major alkaloid in the areca nut, inhibited th
PMID 23933062

Characterization of a unique motif in LIM mineralization protein-1 that interacts with jun activation-domain-binding protein 1.

Sangadala S, Yoshioka K, Enyo Y, Liu Y, Titus L, Boden SD.SourceAtlanta VA Medical Center and Department of Orthopaedics, Emory University School of Medicine, Atlanta, GA, 30329, USA, ssangad@emory.edu.
Molecular and cellular biochemistry.Mol Cell Biochem.2013 Sep 29. [Epub ahead of print]
Development and repair of the skeletal system and other organs are highly dependent on precise regulation of the bone morphogenetic protein (BMP) pathway. The use of BMPs clinically to induce bone formation has been limited in part by the requirement of much higher doses of recombinant proteins in p
PMID 24078030

Japanese Journal

Role of matrix metalloproteinase-10 in the BMP-2 inducing osteoblastic differentiation

Peroxisome proliferator-activated receptor activity is involved in the osteoblastic differentiation regulated by bone morphogenetic proteins and tumor necrosis factor-α.