骨髄造血

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/05 07:23:21」(JST)

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Myelopoiesis is the regulated formation of myeloid cells, including eosinophilic granulocytes, basophilic granulocytes, neutrophilic granulocytes, and monocytes. In hematology, myelopoiesis is the production of blood cells in the bone marrow.

The myeloid progenitor can differentiate in the bone marrow into granulocytes, macrophages (mature monocytes), mast cells (whose blood-borne progenitor is not well defined), and dendritic cells of the innate immune system. The granulocytes, also called polymorphonuclear leukocytes because of their oddly shaped nuclei, give rise to three short lived cell types including eosinophils, basophils, and neutrophils. A granulocyte differentiates into a distinct cell type by a process called granulopoiesis. In this process it first transforms from a common myeloblast (myeloid progenitor) to a common promyelocyte. This promyelocyte gives rise to a unique myelocyte that for the first time can be classified as an eosinophil, basophil, or neutrophil progenitor based on the histological staining affinity (eosinophilic, basophilic, or neutral granules).^[1] The unique myelocyte next differentiates into a metamyelocyte and then a band cell, with a "C" shaped nucleus, before becoming a mature eosinophil, basophil, or neutrophil. Macrophages come from monoblast progenitors that differentriate into promonocytes, which mature into monocytes. Monocytes eventually enter the tissues and become macrophages.

References

^ Junqueira, Carneiro. Basic Histology, Text and Atlas.McGraw-Hill Companies. 2005. ISBN 978-0-07-144116-2

External links

Myelopoiesis at the US National Library of Medicine Medical Subject Headings (MeSH)

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1. 骨髄造血の制御 regulation of myelopoiesis
2. 正常好中球の発生および動態 normal neutrophil development and kinetics
3. 成人における後天性赤芽球癆 acquired pure red cell aplasia in the adult
4. 免疫性好中球減少症 immune neutropenia
5. フェルティ症候群における薬物療法 drug therapy in feltys syndrome

English Journal

GM-CSF: An immune modulatory cytokine that can suppress autoimmunity.

Bhattacharya P1, Thiruppathi M1, Elshabrawy HA1, Alharshawi K1, Kumar P1, Prabhakar BS2.
Cytokine.Cytokine.2015 Oct;75(2):261-71. doi: 10.1016/j.cyto.2015.05.030. Epub 2015 Jun 22.
GM-CSF was originally identified as a colony stimulating factor (CSF) because of its ability to induce granulocyte and macrophage populations from precursor cells. Multiple studies have demonstrated that GM-CSF is also an immune-modulatory cytokine, capable of affecting not only the phenotype of mye
PMID 26113402

GABAergic modulation with classical benzodiazepines prevent stress-induced neuro-immune dysregulation and behavioral alterations.

Ramirez K1, Niraula A2, Sheridan JF3.
Brain, behavior, and immunity.Brain Behav Immun.2015 Sep 3. pii: S0889-1591(15)00467-5. doi: 10.1016/j.bbi.2015.08.011. [Epub ahead of print]
OBJECTIVE: Psychosocial stress is associated with altered immunity, anxiety, and depression. Repeated social defeat (RSD), a model of social stress, triggers egress of inflammatory myeloid progenitor cells (MPCs; CD11b+/Ly6Chi) that traffic to the brain, promoting anxiety-like behavior. In parallel,
PMID 26342944

Transcriptional regulation of myeloid-derived suppressor cells.

Condamine T1, Mastio J1, Gabrilovich DI2.
Journal of leukocyte biology.J Leukoc Biol.2015 Sep 3. pii: jlb.4RI0515-204R. [Epub ahead of print]
Myeloid-derived suppressor cells are a heterogeneous group of pathologically activated immature cells that play a major role in the negative regulation of the immune response in cancer, autoimmunity, many chronic infections, and inflammatory conditions, as well as in the regulation of tumor angiogen
PMID 26337512

Japanese Journal

RhG-CSF Improves Radiation-induced Myelosuppression and Survival in the Canine Exposed to Fission Neutron Irradiation

Yu Zu-Yin,Li Ming,Han A-Ru-Na [他],XING Shuang,OU Hong-Ling,XIONG Guo-Lin,XIE Ling,ZHAO Yan-Fang,XIAO He,SHAN Ya-Jun,ZHAO Zhen-Hu,LIU Xiao-Lan,CONG Yu-Wen,LUO Qing-Liang
Journal of radiation research 52(4), 472-480, 2011-07-16
… Thus, these results demonstrated that rhG-CSF administration enhanced recovery of myelopoiesis and survival after neutron-irradiation. …
NAID 10029122222

生後早期に少量シタラビン (Ara-C) 療法を施行した一過性骨髄増殖症(TAM)の1例

中川真智子,草川功,平田倫生,齋藤怜,笠井恵美,長谷川大輔,真部淳,細谷亮太
日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 47(1), 161-164, 2011-05-01
NAID 10029382296

Transient abnormal myelopoiesis in a cytogenetically normal neonate

YANASE Kentaro,KATO Keisuke,KATAYAMA Nobuko,MOURI Yoko,KOBAYASHI Chie,SHIONO Junko,ABE Masakazu,YOSHIMI Ai,KOIKE Kazutoshi,ARAI Jun-ichi,TSUCHIDA Masahiro
International journal of hematology 92(3), 527-530, 2010-10-15
NAID 10027673669