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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/12/15 00:31:20」(JST)
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A Myelomonocyte is a type of cell observed in chronic myelomonocytic leukemia.[1]
It bears a resemblance to both a myelocyte and monocyte.
It is derived from CFU-GM.
References
- ^ "Definition of myelomonocyte - NCI Dictionary of Cancer Terms". http://www.cancer.gov/dictionary/?searchTxt=myelomonocyte. Retrieved 2009-01-06.
Myeloid lineage - Blood (WBC and RBC)
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Cellular/
HSCs |
Myeloid/
CFU-GEMM
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CFU-GM
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CFU-G:
Granulocytes
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Band cell · Neutrophil
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Macrophages
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Histiocytes · Kupffer cells · Alveolar macrophage · Microglia · Osteoclasts · Epithelioid cells · giant cells (Langhans giant cells, Foreign-body giant cell, Touton giant cells)
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CFU-DL
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Dendritic cells · Langerhans cell
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Common
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Myelomonocyte
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CFU-Baso
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Granulocytes (Basophil)
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CFU-Eos
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Granulocytes (Eosinophil)
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MEP
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CFU-Meg
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Megakaryoblast (* primitive Kacheshmarova's cell) · Megakaryocyte (Kacheshmarova's cell) · Platelets
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CFU-E
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Reticulocyte · Normoblast
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CFU-Mast
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Mast cell precursors
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Noncellular |
Plasma
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cell/phys (coag, heme, immu, gran), csfs
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rbmg/mogr/tumr/hist, sysi/epon, btst
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drug (B1/2/3+5+6), btst, trns
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UpToDate Contents
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English Journal
- Molecular characterization and expression of porcine Siglec-5.
- Escalona Z1, Alvarez B1, Uenishi H2, Toki D2, Yuste M1, Revilla C1, Gómez Del Moral M3, Alonso F1, Ezquerra A1, Domínguez J4.Author information 1Dpto. de Biotecnología, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ctra de la Coruña Km 7.5, 28040 Madrid, Spain.2National Institute of Agrobiological Sciences (NIAS), 2 Ikenodai, Tsukuba, Ibaraki 305-8602, Japan.3Dpto. de Biología Celular, Facultad de Medicina, Universidad Complutense de Madrid, Avda. Complutense s/n, 28040 Madrid, Spain.4Dpto. de Biotecnología, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ctra de la Coruña Km 7.5, 28040 Madrid, Spain. Electronic address: juncal@inia.es.AbstractIn this study we describe the characterization of the porcine orthologue of Siglec-5. A cDNa clone was obtained from a porcine cDNa library derived from swine small intestine which encodes a 555 a-a type 1 transmembrane protein with sequence homology to human Siglec-5. This protein consists of four Ig-like domains, a transmembrane region, and a cytoplasmic tail with two tyrosine-based signalling motifs. When expressed as a recombinant protein fused to the Fc region of human IgG1, porcine Siglec-5 was able to bind porcine red blood cells in a sialic acid-dependent manner. Monoclonal antibodies (mAb) were developed against porcine Siglec-5 and used to analyse its expression in bone marrow and blood cells, and lymphoid tissues. Porcine Siglec-5 expression was mainly restricted to myelomonocytic cells and their precursors, being detected also, although at low levels, on plasmacytoid dendritic cells and B lymphocytes. In lymphoid tissues, ellipsoids of the spleen and subcapsular and medullar sinuses of lymph nodes were positive for Siglec-5. These mAbs were able to precipitate, from granulocyte lysates, a protein of approximately 85kDa under non-reducing conditions, indicating that porcine Siglec-5 is expressed as a monomer in the plasma membrane.
- Developmental and comparative immunology.Dev Comp Immunol.2014 May;44(1):206-16. doi: 10.1016/j.dci.2013.12.013. Epub 2013 Dec 29.
- In this study we describe the characterization of the porcine orthologue of Siglec-5. A cDNa clone was obtained from a porcine cDNa library derived from swine small intestine which encodes a 555 a-a type 1 transmembrane protein with sequence homology to human Siglec-5. This protein consists of four
- PMID 24382335
- Concurrent juvenile myelomonocytic leukemia and T-lymphoblastic lymphoma with a shared missense mutation in NRAS.
- Ly B1, Modi A, Rogers HJ, Makishima H, Hanna R, Cook JR, Theil KS, Maciejewski JP.Author information 1Department of Clinical Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio.AbstractSingle cases of B- and T-lymphoblastic leukemia/lymphoma occurring after remission of JMML, and JMML occurring after remission of B-lymphoblastic leukemia have been reported in the literature. We present a unique case of a child with concurrent JMML and T-lymphoblastic lymphoma in which an identical missense mutation in NRAS was found in both the neoplastic JMML and T-LBL cells. JMML has been considered a stem cell disorder, and our case provides additional molecular evidence for a stem cell lesion underlying the two different disease phenotypes. Pediatr Blood Cancer 2014;61:946-948. © 2013 Wiley Periodicals, Inc.
- Pediatric blood & cancer.Pediatr Blood Cancer.2014 May;61(5):946-8. doi: 10.1002/pbc.24797. Epub 2013 Oct 8.
- Single cases of B- and T-lymphoblastic leukemia/lymphoma occurring after remission of JMML, and JMML occurring after remission of B-lymphoblastic leukemia have been reported in the literature. We present a unique case of a child with concurrent JMML and T-lymphoblastic lymphoma in which an identical
- PMID 24610751
- Germline CBL mutation associated with a noonan-like syndrome with primary lymphedema and teratoma associated with acquired uniparental isodisomy of chromosome 11q23.
- Hanson HL1, Wilson MJ, Short JP, Chioza BA, Crosby AH, Nash RM, Marks KJ, Mansour S.Author information 1SW Thames Regional Genetics Service, St George's Healthcare NHS Trust, London, UK.AbstractGermline mutations in the gene CBL (Casitas B-lineage lymphoma), involved in the RAS-MAPK signaling pathway, have been found as a rare cause of the neuro-cardio-facial-cutaneous syndromes. Somatically acquired homozygous CBL mutations were initially identified in association with myeloproliferative disorders, particularly juvenile myelomonocytic leukemia (JMML). We describe a girl with a Noonan-like phenotype of bilateral ptosis, lymphedema of the lower limbs and moderate intellectual disability, due to a de novo heterozygous mutation in CBL. She developed an ovarian mixed germ cell/teratoma with later occurrence of mature liver, omental, and ovarian teratomas. Copy neutral loss of heterozygosity for the CBL mutation due to acquired segmental uniparental disomy of 11q23 was observed in three teratomas, suggesting a specific association of CBL mutations in germ cell tumor predisposition. © 2014 Wiley Periodicals, Inc.
- American journal of medical genetics. Part A.Am J Med Genet A.2014 Apr;164(4):1003-9. doi: 10.1002/ajmg.a.36375. Epub 2014 Jan 23.
- Germline mutations in the gene CBL (Casitas B-lineage lymphoma), involved in the RAS-MAPK signaling pathway, have been found as a rare cause of the neuro-cardio-facial-cutaneous syndromes. Somatically acquired homozygous CBL mutations were initially identified in association with myeloproliferative
- PMID 24458550
Japanese Journal
- TGF-β Decreases the Stability of IL-18-Induced IFN-γ mRNA through the Expression of TGF-β-Induced Tristetraprolin in KG-1 Cells
- , , [他],
- Biological and Pharmaceutical Bulletin 38(4), 536-544, 2015
- … In the present study, we investigated the mechanism of the down-regulatory effects of TGF-β on IFN-γ mRNA expression in a human myelomonocytic cell line, KG-1, which produces IFN-γ in response to IL-18 alone. …
- NAID 130005062261
- <I>XRCC1</I> Arg194Trp and <I>XRCC1</I> Arg399Gln Polymorphisms Affect Clinical Features and Prognosis of Myelodysplastic Syndromes
- , , [他], ,
- 北関東医学 65(1), 11-19, 2015
- … Arg399Gln, with susceptibility to and clinical outcome of MDS.Methods: Our study included 119 patients with MDS or chronic myelomonocytic leukemia[median 67.9 years, range 17.1-86.5 years; …
- NAID 130005060930
Related Links
- After taking their son to UCSF s Pediatric Oncology Clinic, the Harrises finally received a diagnosis: Evan had Juvenile Myelomonocytic Leukemia, or JMML, a rare but very aggressive cancer of the blood that typically afflicts young ...
- 23 and mutant B7 constructs were introduced into the murine myelomonocytic cell line, 32D, and assayed for their effec 24 Moreover, when tested in a porcine myelomonocytic cell line, NSP1beta inhibited Sendai virus-25 cell 26 ...
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