WordNet
- processing a photosensitive material in order to make an image visible; "the development and printing of his pictures took only two hours" (同)developing
- a process in which something passes by degrees to a different stage (especially a more advanced or mature stage); "the development of his ideas took many years"; "the evolution of Greek civilization"; "the slow development of her skill as a writer" (同)evolution
- a state in which things are improving; the result of developing (as in the early part of a game of chess); "after he saw the latest development he changed his mind and became a supporter"; "in chess your should take care of your development before moving your queen"
- act of improving by expanding or enlarging or refining; "he congratulated them on their development of a plan to meet the emergency"; "they funded research and development"
- (music) the section of a composition or movement (especially in sonata form) where the major musical themes are developed and elaborated
- a district that has been developed to serve some purpose; "such land is practical for small park developments"
- a recent event that has some relevance for the present situation; "recent developments in Iraq"; "what a revolting development!"
- of or relating to or consisting of muscle; "muscular contraction"
- having or suggesting great physical power or force; "the muscular and passionate Fifth Symphony"
PrepTutorEJDIC
- 〈U〉〈C〉『発達』,発展,発育,成長;『開発』;進化 / 〈U〉(写真の)現像 / 〈C〉発達(発展)の結果できたもの / 〈C〉開発した土地(地区);(特に)住宅団地(housing development) / 〈C〉(最近の)でき事,新事実
- 『助肉の』,筋肉でできた / 筋肉による / 筋肉の発達した
UpToDate Contents
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- 1. 脊髄性筋萎縮症 spinal muscular atrophy
- 2. 眼咽頭型、遠位型，および先天性筋ジストロフィー oculopharyngeal distal and congenital muscular dystrophies
- 3. 肢帯型筋ジストロフィー limb girdle muscular dystrophy
- 4. エメリー‐ドレフェス型筋ジストロフィー emery dreifuss muscular dystrophy
- 5. デュシェンヌ型およびベッカー型筋ジストロフィーの臨床的特徴および診断 clinical features and diagnosis of duchenne and becker muscular dystrophy
English Journal
- Caveolin 1 is critical for abdominal aortic aneurysm formation induced by angiotensin II and inhibition of lysyl oxidase.
- Takayanagi T1, Crawford KJ, Kobayashi T1, Obama T1, Tsuji T1, Elliott KJ1, Hashimoto T2, Rizzo V, Eguchi S1.Author information 1*Cardiovascular Research Center, Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, U.S.A.2‡Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, U.S.A.AbstractAlthough AngII (angiotensin II) and its receptor AT1R (AngII type 1 receptor) have been implicated in AAA (abdominal aortic aneurysm) formation, the proximal signalling events primarily responsible for AAA formation remain uncertain. Caveolae are cholesterol-rich membrane microdomains that serve as a signalling platform to facilitate the temporal and spatial localization of signal transduction events, including those stimulated by AngII. Cav1 (caveolin 1)-enriched caveolae in vascular smooth muscle cells mediate ADAM17 (a disintegrin and metalloproteinase 17)-dependent EGFR (epidermal growth factor receptor) transactivation, which is linked to vascular remodelling induced by AngII. In the present study, we have tested our hypothesis that Cav1 plays a critical role for the development of AAA at least in part via its specific alteration of AngII signalling within caveolae. Cav1-/- mice and the control wild-type mice were co-infused with AngII and β-aminopropionitrile to induce AAA. We found that Cav1-/- mice with the co-infusion did not develop AAA compared with control mice in spite of hypertension. We found an increased expression of ADAM17 and enhanced phosphorylation of EGFR in AAA. These events were markedly attenuated in Cav1-/- aortas with the co-infusion. Furthermore, aortas from Cav1-/- mice with the co-infusion showed less endoplasmic reticulum stress, oxidative stress and inflammatory responses compared with aortas from control mice. Cav1 silencing in cultured vascular smooth muscle cells prevented AngII-induced ADAM17 induction and activation. In conclusion, Cav1 appears to play a critical role in the formation of AAA and associated endoplasmic reticulum/oxidative stress, presumably through the regulation of caveolae compartmentalized signals induced by AngII.
- Clinical science (London, England : 1979).Clin Sci (Lond).2014 Jun 1;126(11):785-94. doi: 10.1042/CS20130660.
- Although AngII (angiotensin II) and its receptor AT1R (AngII type 1 receptor) have been implicated in AAA (abdominal aortic aneurysm) formation, the proximal signalling events primarily responsible for AAA formation remain uncertain. Caveolae are cholesterol-rich membrane microdomains that serve as
- PMID 24329494
- A multi-scale mechanobiological model of in-stent restenosis: deciphering the role of matrix metalloproteinase and extracellular matrix changes.
- Zahedmanesh H1, Van Oosterwyck H, Lally C.Author information 1a Biomechanics Section, Department of Mechanical Engineering , KU Leuven , Leuven , Belgium.AbstractSince their first introduction, stents have revolutionised the treatment of atherosclerosis; however, the development of in-stent restenosis still remains the Achilles' heel of stent deployment procedures. Computational modelling can be used as a means to model the biological response of arteries to different stent designs using mechanobiological models, whereby the mechanical environment may be used to dictate the growth and remodelling of vascular cells. Changes occurring within the arterial wall due to stent-induced mechanical injury, specifically changes within the extracellular matrix, have been postulated to be a major cause of activation of vascular smooth muscle cells and the subsequent development of in-stent restenosis. In this study, a mechanistic multi-scale mechanobiological model of in-stent restenosis using finite element models and agent-based modelling is presented, which allows quantitative evaluation of the collagen matrix turnover following stent-induced arterial injury and the subsequent development of in-stent restenosis. The model is specifically used to study the influence of stent deployment diameter and stent strut thickness on the level of in-stent restenosis. The model demonstrates that there exists a direct correlation between the stent deployment diameter and the level of in-stent restenosis. In addition, investigating the influence of stent strut thickness using the mechanobiological model reveals that thicker strut stents induce a higher level of in-stent restenosis due to a higher extent of arterial injury. The presented mechanobiological modelling framework provides a robust platform for testing hypotheses on the mechanisms underlying the development of in-stent restenosis and lends itself for use as a tool for optimisation of the mechanical parameters involved in stent design.
- Computer methods in biomechanics and biomedical engineering.Comput Methods Biomech Biomed Engin.2014 Jun;17(8):813-28. doi: 10.1080/10255842.2012.716830. Epub 2012 Sep 12.
- Since their first introduction, stents have revolutionised the treatment of atherosclerosis; however, the development of in-stent restenosis still remains the Achilles' heel of stent deployment procedures. Computational modelling can be used as a means to model the biological response of arteries to
- PMID 22967148
- Evaluating the physical demands on firefighters using hand-carried stair descent devices to evacuate mobility-limited occupants from high-rise buildings.
- Lavender SA1, Hedman GE2, Mehta JP3, Reichelt PA4, Conrad KM4, Park S3.Author information 1Integrated Systems Engineering, The Ohio State University, Columbus, OH, USA; Department of Orthopedics, The Ohio State University, Columbus, OH, USA. Electronic address: Lavender.1@osu.edu.2Department of Disability and Human Development, The University of Illinois at Chicago, Chicago, IL, USA.3Integrated Systems Engineering, The Ohio State University, Columbus, OH, USA.4Division of Health Policy and Administration, School of Public Health, The University of Illinois at Chicago, Chicago, IL, USA.AbstractThe physical demands on firefighting personnel were investigated when using different types of hand-carried stair descent devices designed for the emergency evacuation of high rise buildings as a function of staircase width and evacuation urgency. Twelve firefighters used three hand-carried stair descent devices during simulated urgent and non-urgent evacuations. The devices were evaluated under three staircase width conditions (0.91, 1.12, and 1.32 m). For comparison, an urgent manual carry was also performed on the 1.12 m wide stairs. Dependent measures included electromyographic (EMG) data, heart rates, Borg Scale ratings, task durations and descent velocities. Results indicated that the stair chair with extended front handles, which allows the front person to descend the stairs facing forward, reduced the time integrated back muscle EMG by half and showed a descent velocity that was 1.8 times faster than the other stair descent devices in the study. There were no differences across staircase widths.
- Applied ergonomics.Appl Ergon.2014 May;45(3):389-97. doi: 10.1016/j.apergo.2013.05.005. Epub 2013 Jun 4.
- The physical demands on firefighting personnel were investigated when using different types of hand-carried stair descent devices designed for the emergency evacuation of high rise buildings as a function of staircase width and evacuation urgency. Twelve firefighters used three hand-carried stair de
- PMID 23759793
Japanese Journal
- Influence of mandibular deviation on maxillofacial morphology evaluated by cone beam computed tomography
- Nagaki Emiko,Nishiura Aki,Gamoh Shoko,Yotsui Yoritaka,Shimizutani Kimishige,Matsumoto Naoyuki
- Journal of Osaka Dental University 46(1), 207-213, 2012-04
- … The muscular function of the jaw is concerned with maxillofacial growth and the development of the masticatory muscles. …
- NAID 110009436552
- 患者由来細胞を用いたデュシェンヌ型筋ジストロフィーに対するエクソン・スキッピング治療の開発
- 齊藤 崇,永田 哲也,青木 吉嗣,谷端 淳,増田 智,本橋 裕子,横田 俊文,武田 伸一
- 臨床薬理 = Japanese journal of clinical pharmacology 43(2), 91-92, 2012-03-31
- NAID 10030573955
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★リンクテーブル★
| リンク元 | 「myogenesis」「myofibrillogenesis」「筋発生」「muscle development」 |
| 関連記事 | 「development」「muscular」 |
「myogenesis」
「myofibrillogenesis」
「筋発生」
「muscle development」
「development」
- n.
- 関
- buildup、deployment、develop、developmental、emergence、engender、evolution、expand、exploit、exploitation、generate、generation、growth、occur、occurrence、onset、transpire、unfold
「muscular」
- adj.
- 筋肉の、筋の