multiple organ dysfunctional syndrome

多臓器機能障害症候群

同

MODS

WordNet

1. wind instrument whose sound is produced by means of pipes arranged in sets supplied with air from a bellows and controlled from a large complex musical keyboard (同)pipe_organ
2. a fully differentiated structural and functional unit in an animal that is specialized for some particular function
3. a government agency or instrument devoted to the performance of some specific function; "The Census Bureau is an organ of the Commerce Department"
4. a periodical that is published by a special interest group; "the organ of the communist party"
5. (medicine) any disturbance in the functioning of an organ or body part or a disturbance in the functioning of a social group; "erectile dysfunction"; "sexual relationship dysfunction" (同)disfunction
6. having or involving or consisting of more than one part or entity or individual; "multiple birth"; "multiple ownership"; "made multiple copies of the speech"; "his multiple achievements in public life"; "her multiple personalities"; "a pineapple is a multiple fruit"
7. the product of a quantity by an integer; "36 is a multiple of 9"
8. a pattern of symptoms indicative of some disease
9. a complex of concurrent things; "every word has a syndrome of meanings"
10. impaired in function; especially of a bodily system or organ
11. (of a trait or condition) failing to serve an adjustive purpose; "dysfunctional behavior" (同)nonadaptive

PrepTutorEJDIC

1. 『オルガン』,パイプオルガン(pipe organ),リードオルガン(reed organ),電子オルガン(electronic organ),手回しオルガン(barrel organ) / (動植物の)『器官』 / (政党・会社などの)機関誌,機関紙 / 《しばしば複数形で》(行動・実施などの)組織,機関
2. 機能障害,機能不全
3. 多数の部分(要素)から成る,複合の,複式の / 倍数
4. (疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態

UpToDate Contents

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• 1. 敗血症および全身性炎症反応症候群：定義、疫学、および予後 sepsis and the systemic inflammatory response syndrome definitions epidemiology and prognosis
• 2. 敗血症の病態生理 pathophysiology of sepsis
• 3. 成人における重症敗血症および敗血症性ショックの評価およびマネージメント evaluation and management of severe sepsis and septic shock in adults
• 4. 中央アフリカへの旅行によって感染する可能性のある疾患 diseases potentially acquired by travel to central africa
• 5. 小児における全身性炎症反応症候群（SIRS）および敗血症：定義、疫学、臨床症状、および診断 systemic inflammatory response syndrome sirs and sepsis in children definitions epidemiology clinical manifestations and diagnosis

English Journal

• Structural defects in cilia of the choroid plexus, subfornical organ and ventricular ependyma are associated with ventriculomegaly.

• Swiderski RE, Agassandian K, Ross JL, Bugge K, Cassell MD, Yeaman C.Author information Department of Anatomy and Cell Biology, The University of Iowa, Iowa City, 52242, IA, USA. charles-yeaman@uiowa.edu.Abstract
• Fluids and barriers of the CNS.Fluids Barriers CNS.2012 Oct 9;9(1):22. doi: 10.1186/2045-8118-9-22.
• BACKGROUND: Hydrocephalus is a heterogeneous disorder with multiple etiologies that are not yet fully understood. Animal models have implicated dysfunctional cilia of the ependyma and choroid plexus in the development of the disorder. In this report, we sought to determine the origin of the ventricu
• PMID 23046663

• Sepsis, thrombosis and organ dysfunction.

• Semeraro N, Ammollo CT, Semeraro F, Colucci M.Author information Department of Biomedical Sciences and Human Oncology, Section of General, Experimental and Clinical Pathology, University of Bari, Bari, Italy. semeraro@dimo.uniba.itAbstractSepsis is often associated with haemostatic changes ranging from subclinical activation of blood coagulation (hypercoagulability), which may contribute to localized venous thromboembolism, to acute disseminated intravascular coagulation (DIC), characterized by widespread microvascular thrombosis and subsequent consumption of platelets and coagulation proteins, eventually causing bleeding manifestations. The key event underlying this life-threatening complication is the overwhelming inflammatory host response to the infectious agent leading to the overexpression of inflammatory mediators. The latter, along with the micro-organism and its derivatives are now believed to drive the major changes responsible for massive thrombin formation and fibrin deposition, namely 1) the aberrant expression of the TF by different cells (especially monocytes-macrophages), 2) the impairment of physiological anticoagulant pathways, orchestrated mainly by dysfunctional endothelial cells (ECs) and 3) the suppression of fibrinolysis due to overproduction of plasminogen activator inhibitor-1 (PAI-1) by ECs and likely also to thrombin-mediated activation of thrombin-activatable fibrinolysis inhibitor (TAFI). The ensuing microvascular thrombosis and ischemia are thought to contribute to tissue injury and multiple organ dysfunction syndrome (MODS). Recent evidence indicates that extracellular nuclear materials released from activated and especially apoptotic or necrotic cells, e.g. High Mobility Group Box-1 (HMGB-1) and histones, are endowed with cell toxicity, proinflammatory and clot-promoting properties and thus, during sepsis, they may represent late mediators that propagate further inflammation, coagulation, cell death and MODS. These insights into the pathogenesis of DIC and MODS may have implications for the development of new therapeutic agents potentially useful for the management of severe sepsis.
• Thrombosis research.Thromb Res.2012 Mar;129(3):290-5. doi: 10.1016/j.thromres.2011.10.013. Epub 2011 Nov 5.
• Sepsis is often associated with haemostatic changes ranging from subclinical activation of blood coagulation (hypercoagulability), which may contribute to localized venous thromboembolism, to acute disseminated intravascular coagulation (DIC), characterized by widespread microvascular thrombosis and
• PMID 22061311

• [Effect of continuous renal replacement therapy started at different time on patients with multiple organ dysfunction syndrome].

• Yao LQ, Jin ZC, Ji MS, Xia CY, Yu ZX, Liu J, Hu XL, Yan J.Author information Department of Nephrology, Jiangsu University, Zhenjiang 212002, China.AbstractOBJECTIVE: To explore the effects of continuous renal replacement therapy (CRRT) on serum cytokines and prognosis in multiple organ dysfunction syndrome (MODS) patients based on different therapeutic opportunities.
• Zhonghua yi xue za zhi.Zhonghua Yi Xue Za Zhi.2011 Jun 28;91(24):1663-7.
• OBJECTIVE: To explore the effects of continuous renal replacement therapy (CRRT) on serum cytokines and prognosis in multiple organ dysfunction syndrome (MODS) patients based on different therapeutic opportunities.METHODS: A total of 34 MODS patients in the treatment of CRRT after admission to ICU o
• PMID 21914312

Japanese Journal

• 敗血症性多臓器不全 : 障害臓器数と病態,各種mediatorとの関連(<特集>多臓器不全とアフェレシス)

• 谷内 仁,池田 寿昭,池田 一美,松下 美季子,名倉 正利,木内 信太郎,黒木 雄一,鈴木 香里
• 日本アフェレシス学会雑誌 23(1), 88-92, 2004-02-29
• … Changes in hemodynamics and a variety of mediators such as cytokines were compared with respect to the number of dysfunctional organs in MODS cases treated with blood purification. … Organ dysfunction was evaluated using the MOF score according to Goris, where organ dysfunction was judged positive when the score was more than 1 point for each organ. …
• NAID 110003144606

Related Links

• Multiple organ dysfunction syndrome - Wikipedia, the free ...

Multiple organ dysfunction syndrome (MODS), previously known as multiple organ failure (MOF) or multisystem organ failure (MSOF), is altered organ function in an acutely ill patient requiring medical intervention to achieve homeostasis.

• The multiple organ dysfunction syndrome - Surgical Treatment ...

The most common cause of death for patients admitted to a contemporary intensive care unit (ICU) is a clinical condition that owes its existence to the development of the ICU. Variously known as the multiple organ dysfunction syndrome ...

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★リンクテーブル★

リンク元	「多臓器機能障害症候群」
関連記事	「dysfunction」「multiple」「organ」「multiple organ」「syndrome」

「多臓器機能障害症候群」

　　[★]

英

multiple organ dysfunction syndrome MODS, multiple organ dysfunctional syndrome

同

多臓器機能障害、多臓器障害、多臓器損傷、多臓器不全症候群

関

多臓器不全 multiorgan failure

定義

• 2つ以上の主要臓器の機能異常(ICU.642)

多臓器不全の構成要素 ICU.642改

• 敗血症性脳症
• 重症疾患多発神経障害、筋障害
• 急性呼吸窮迫症候群
• 敗血症性ショック
• 上部消化管出血
• イレウス、細菌のトランスロケーション
• 腎障害
• 急性尿細管壊死
• 播種性血管内凝固

「dysfunction」

　　[★]

• n.

• 機能不全、機能障害、機能異常

• vi

• 機能不全に陥る

関

barrier、damage、difficulty、disorder、disturbance、foe、functional disorder、functional impairment、hindrance、hypofunction、impair、impairment、impediment、incompetence、insufficiency、lesion、malfunction、obstacle、stun

　 　

「multiple」

　　[★]

• n.

• 倍数

• adj.

関

multifocality、multiplex、plural

　 　 　

「organ」

　　[★]

• n.

• 臓器、器官

　 　 　 　 　

「multiple organ」

　　[★]

• 多臓器の

関

multiorgan

「syndrome」

　　[★]

• n.

• 症候群