multiple endocrine neoplasia type 1

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多発性内分泌腫瘍症1型

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/16 21:58:53」(JST)

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英文文献

  • Shortness: an unknown phenotype of multiple endocrine neoplasia type 1.
  • López CL, Langer P, Waldmann J, Fendrich V, Sitter H, Nies C, Bartsch DK.SourceDepartment of Surgery, University Hospital Giessen and Marburg, Marburg, Germany. lopez@med.uni-marburg.de
  • European journal of endocrinology / European Federation of Endocrine Societies.Eur J Endocrinol.2013 Jul;169(1):133-7.
  • OBJECTIVE: An observation of shortness among the female participants of a regular screening program in multiple endocrine neoplasia type 1 (MEN1) patients has raised the question as to whether shortness represents a phenotype characteristic of the disease.METHODS: The body height (cm) of genetically
  • PMID 23828958
  • Growth hormone-releasing hormone-producing pancreatic neuroendocrine tumor in a multiple endocrine neoplasia type 1 family with an uncommon phenotype.
  • Sala E, Ferrante E, Verrua E, Malchiodi E, Mantovani G, Filopanti M, Ferrero S, Pietrabissa A, Vanoli A, La Rosa S, Zatelli MC, Beck-Peccoz P, Verga U.SourceaDepartment of Clinical Sciences and Community Health, Endocrinology and Diabetology Unit bDepartment of Medicine, Surgery and Dentistry, Pathology Unit, University of Milan, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan Departments of c2nd General Surgery dPathology, University of Pavia and IRCCS Policlinico S. Matteo, Pavia eDepartment of Pathology, Ospedale di Circolo, Varese fDepartment of Biomedical Sciences and Advanced Therapies, Section of Endocrinology, University of Ferrara, Ferrara, Italy.
  • European journal of gastroenterology & hepatology.Eur J Gastroenterol Hepatol.2013 Jul;25(7):858-862.
  • The objective of this study was to describe a multiple endocrine neoplasia type 1 (MEN1) family characterized by primary hyperparathyroidism, in association with acromegaly because of ectopic growth hormone-releasing hormone (GHRH) secretion by a pancreatic neuroendocrine tumor in a young man and wi
  • PMID 23542451
  • MEN1 Is a Melanoma Tumor Suppressor That Preserves Genomic Integrity by Stimulating Transcription of Genes That Promote Homologous Recombination-Directed DNA Repair.
  • Fang M, Xia F, Mahalingam M, Virbasius CM, Wajapeyee N, Green MR.SourceHoward Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Molecular and cellular biology.Mol Cell Biol.2013 Jul;33(13):2635-47. doi: 10.1128/MCB.00167-13. Epub 2013 May 6.
  • Multiple endocrine neoplasia type 1 is a familial cancer syndrome resulting from loss-of-function mutations in the MEN1 gene. We previously identified the tumor suppressor MEN1 as a gene required for oncogene-induced senescence in melanocytes, raising the possibility that MEN1 is a melanoma tumor su
  • PMID 23648481

和文文献

  • 多発性内分泌腫瘍症2(Multiple endocrine neoplasia type 2 : MEN2) 医療の進歩
  • 五十嵐 健人
  • 日本医科大学医学会雑誌 11(1), 6-11, 2015-02
  • NAID 40020399808
  • 多発性内分泌腫瘍症2(Multiple endocrine neoplasia type 2:MEN2)医療の進歩
  • 五十嵐 健人
  • 日本医科大学医学会雑誌 11(1), 6-11, 2015
  • Multiple endocrine neoplasia type 2 (MEN2) is an autosomal, predominantly hereditary disease characterized by medullary thyroid carcinoma, pheochromocytoma, and primary hyperparathyroidism; … it is classified into type 2A, type 2B, and familial medullary thyroid carcinoma (FMTC). …
  • NAID 130004941845
  • The Role of Genetic and Epigenetic Changes in Pituitary Tumorigenesis
  • FUKUOKA Hidenori,TAKAHASHI Yutaka
  • Neurologia medico-chirurgica, 2014
  • … Genetic analysis in rare familial pituitary adenomas, including multiple endocrine neoplasia type 1 and type 4, Carney complex, familial isolated pituitary adenomas, and succinate dehydrogenases (SDHs)-mediated paraganglioma syndrome, revealed several causal germline mutations and sporadic somatic mutations in these genes. …
  • NAID 130004922290

関連リンク

Multiple endocrine neoplasia type 1 (MEN1) is characterized by the occurrence of parathyroid, pancreatic islet and anterior pituitary tumors. Some patients may also develop carcinoid tumors, adrenocortical tumors, facial ...
Multiple Endocrine Neoplasia type 1 (MEN1) is a rare autosomal dominant hereditary cancer syndrome presented mostly by tumours of the parathyroids, endocrine pancreas and anterior pituitary, and characterised by a ...

関連画像

Multiple endocrine neoplasia type 1 (MEN1  men 1 multiple endocrine neoplasia type 1Multiple Endocrine Neoplasia Type 1 Figure Multiple Endocrine Neoplasia Type 1Multiple endocrine neoplasia type 1 (MEN 1 Multiple endocrine neoplasia type 1: new


★リンクテーブル★
先読みMEN-1
リンク元」「多発性内分泌腫瘍症1型
関連記事type」「multiple」「endocrine」「neoplasia」「typing

MEN-1」

  [★] 多発性内分泌腫瘍症1型


癌」

  [★]

cancer
悪性腫瘍


種類

  • 癌腫(carcinoma):上皮性
  • 肉腫(sarcoma):間葉系
  • carcinoma:腺癌(adenocarcinma)、扁平上皮癌(squamous cell carcinoma)、移行上皮癌(transitional cell carcinoma)
  • sarcoma:骨肉腫、横紋筋肉腫、平滑筋肉腫、脂肪肉腫、線維肉腫

Neoplasm Causes Effect
Small cell lung carcinoma ACTH or ACTH-like peptide Cushing’s syndrome
Small cell lung carcinoma and intracranial neoplasms ADH SIADH
Squamous cell lung carcinoma, renal cell carcinoma, breast carcinoma, multiple myeloma, and bone metastasis (lysed bone) PTH-related peptide, TGF-β, TNF-α, IL-1 Hypercalcemia
Renal cell carcinoma, hemangioblastoma Erythropoietin Polycythemia
Thymoma, small cell lung carcinoma Antibodies against presynaptic Ca2+ channels at neuromuscular junction Lambert-Eaton syndrome (muscle weakness)
Leukemias and lymphomas Hyperuricemia due to excess nucleic acid turnover (i.e., cytotoxic therapy) Gout, urate nephropathy
  • 最新癌統計
http://ganjoho.ncc.go.jp/public/statistics/pub/statistics01.html
●2005年の死亡数が多い部位は順に
  1位 2位 3位 4位 5位  
男性 肝臓 結腸 膵臓 結腸と直腸を合わせた大腸は4位
女性 結腸 肝臓 乳房 結腸と直腸を合わせた大腸は1位
男女計 肝臓 結腸 膵臓 結腸と直腸を合わせた大腸は3位
 
●2001年の罹患数が多い部位は順に
  1位 2位 3位 4位 5位  
男性 結腸 肝臓 前立腺 結腸と直腸を合わせた大腸は2位
女性 乳房*1 結腸 子宮*1 結腸と直腸を合わせた大腸は1位
男女計 結腸 乳房*1 肝臓 結腸と直腸を合わせた大腸は2位
*1上皮内がんを含む。


癌の素因となる遺伝子

HIM.494
Table 79-1 Cancer Predisposition Syndromes and Associated Genes
Syndrome Gene Chromosome Inheritance Tumors
ataxia telangiectasia ATM  11q22-q23 AR breast cancer
autoimmune lymphoproliferative syndrome FAS 10q24 AD lymphomas
FASL 1q23  
Bloom syndrome BLM  15q26.1 AR cancer of all types
Cowden syndrome PTEN  10q23 AD breast, thyroid
familial adenomatous polyposis APC  5q21 AD intestinal adenoma, colorectal cancer
familial melanoma p16INK4  9p21 AD melanoma, pancreatic cancer
familial Wilms tumor WT1  11p13 AD pediatric kidney cancer
hereditary breast/ovarian cancer BRCA1 17q21 AD breast, ovarian, colon, prostate
BRCA2 13q12.3  
hereditary diffuse gastric cancer CDH1  16q22 AD stomach cancers
hereditary multiple exostoses EXT1 8q24 AD exostoses, chondrosarcoma
EXT2 11p11-12  
hereditary prostate cancer HPC1  1q24-25 AD prostate carcinoma
hereditary retinoblastoma RB1  13q14.2 AD retinoblastoma, osteosarcoma
hereditary nonpolyposis colon cancer (HNPCC) MSH2 2p16 AD colon, endometrial, ovarian, stomach, small bowel, ureter carcinoma
MLH1 3p21.3  
MSH6 2p16  
PMS2 7p22  
hereditary papillary renal carcinoma MET  7q31 AD papillary renal tumor
juvenile polyposis SMAD4  18q21 AD gastrointestinal, pancreatic cancers
Li-Fraumeni TP53  17p13.1 AD sarcoma, breast cancer
multiple endocrine neoplasia type 1 MEN1  11q13 AD parathyroid, endocrine, pancreas, and pituitary
multiple endocrine neoplasia type 2a RET  10q11.2 AD medullary thyroid carcinoma, pheochromocytoma
neurofibromatosis type 1 NF1  17q11.2 AD neurofibroma, neurofibrosarcoma, brain tumor
neurofibromatosis type 2 NF2  22q12.2 AD vestibular schwannoma, meningioma, spine
nevoid basal cell carcinoma syndrome (Gorlin's syndrome) PTCH  9q22.3 AD basal cell carcinoma, medulloblastoma, jaw cysts
tuberous sclerosis TSC1 9q34 AD angiofibroma, renal angiomyolipoma
TSC2 16p13.3  
von Hippel–Lindau VHL  3p25-26 AD kidney, cerebellum, pheochromocytoma
癌遺伝子癌抑制遺伝子

癌の危険因子

生活習慣病#生活習慣病などのリスクファクターを改変
疾患 危険因子 防御因子
悪性腫瘍 胃癌 塩辛い食品、喫煙、くん製製品、ニトロソアミン土壌、腸上皮化生Helicobacter pyroli ビタミンC、野菜、果実
食道癌 喫煙飲酒、熱い飲食物 野菜、果実
結腸癌 高脂肪食、肉食、低い身体活動、腸内細菌叢の変化、遺伝(家族性大腸腺腫症)  
肝癌 HBVキャリア・HCVキャリア、アフラトキシン住血吸虫飲酒  
肺癌 喫煙(特に扁平上皮癌)、大気汚染、職業的暴露(石綿(扁平上皮癌悪性中皮腫)、クロム) 野菜、果実
膵癌 高脂肪食喫煙  
口腔癌 喫煙(口唇・舌-パイプ)、ビンロウ樹の実(口腔)、飲酒  
咽頭癌 EBウイルス(上咽頭癌)、飲酒  
喉頭癌 喫煙男性アルコール  
乳癌 高年初産、乳癌の家族歴、肥満、未婚で妊娠回数少ない、無授乳、脂肪の過剰摂取、低年齢初経、高年齢閉経 母乳授乳
子宮頚癌 初交年齢若い、早婚、多産、性交回数が多い(売春)、貧困、不潔]、HSV-2HPV流産、人工妊娠中絶回数が多い  
子宮体癌 肥満糖尿病ピルエストロゲン常用、未婚、妊娠回数少ない、乳癌後のタモキシフエン内服  
膀胱癌 喫煙鎮痛剤乱用、ビルハルツ住血吸虫サッカリン防腐剤  
皮膚癌 日光(紫外線)、ヒ素(Bowen病)  
白血病 放射線ベンゼン、地域集積性(ATL)、ダウン症(小児白血病)  
骨腫瘍 電離放射線  
甲状腺癌 ヨード欠乏または過剰  



多発性内分泌腫瘍症1型」

  [★]

multiple endocrine neoplasia type 1 MEN-1 MEN1, MEN I
ウェルマー症候群 Wermer症候群 Wermer syndrome。(国試)多発性内分泌腫瘍I型
multiple endocrine neoplasia type 1multiple endocrine neoplasia type I
多発性内分泌腫瘍症, MEN
  • first aid step1 2006 p.254,257,428

病因

遺伝形式

症候

疾患内分泌腺 腫瘍 発生頻度 関連疾患
MEN 1
(Wermer症候群)
下垂体 下垂体腺腫 16-66% 腸管カルチノイド、
脂肪腫(~10%)、
平滑筋腫
副腎皮質腫瘍(~40%)、
甲状腺腺腫(26%)
副甲状腺 副甲状腺過形成
副甲状腺腺腫
90-97%
膵臓 膵島腫 30-80%
  • 膵臓の腫瘍
  • 胃癌(HIM.1868)



type」

  [★]

  • n.
(windows)ファイル内容表示(linux -> cat])
ex. type report_20111118.jp.htm | php a.php > report_20111118.jp.jp.jp.html
formmodepatterntype specimentyped

WordNet   license wordnet

「write by means of a keyboard with types; "type the acceptance letter, please"」
typewrite

WordNet   license wordnet

「(biology) the taxonomic group whose characteristics are used to define the next higher taxon」

WordNet   license wordnet

「a subdivision of a particular kind of thing; "what type of sculpture do you prefer?"」

WordNet   license wordnet

「all of the tokens of the same symbol; "the word `element'' contains five different types of character"」

WordNet   license wordnet

「printed characters; "small type is hard to read"」

PrepTutorEJDIC   license prepejdic

「〈C〉(…の)『型』,タイプ,類型,種類(kind)《+of+名》 / 〈C〉(その種類の特質を最もよく表している)『典型』,手本,模範《+of+名》 / 〈U〉《集合的に》活字;〈C〉(1個の)活字 / 〈U〉(印刷された)字体,活字 / 〈C〉(貨幣・メダルなどの)模様,図柄 / 〈C〉血液型(blood group) / …‘を'タイプに打つ / (…として)…‘を'分類する《+名+as+名(doing)》 / …‘の'型を決める / タイプライターを打つ」

WordNet   license wordnet

「a small metal block bearing a raised character on one end; produces a printed character when inked and pressed on paper; "he dropped a case of type, so they made him pick them up"」

WordNet   license wordnet

「identify as belonging to a certain type; "Such people can practically be typed"」
typecast


multiple」

  [★]

  • n.
  • 倍数
  • adj.
multifocalitymultiplexplural

WordNet   license wordnet

「having or involving or consisting of more than one part or entity or individual; "multiple birth"; "multiple ownership"; "made multiple copies of the speech"; "his multiple achievements in public life"; "her multiple personalities"; "a pineapple is a multiple fruit"」

WordNet   license wordnet

「the product of a quantity by an integer; "36 is a multiple of 9"」

PrepTutorEJDIC   license prepejdic

「多数の部分(要素)から成る,複合の,複式の / 倍数」


endocrine」

  [★]

  • n.
endocrinic, endocrinal

WordNet   license wordnet

「of or belonging to endocrine glands or their secretions; "endocrine system"」
endocrinal

PrepTutorEJDIC   license prepejdic

「内分泌(ぶんぴつ)の / 内分泌物;内分泌腺(せん)」


neoplasia」

  [★]

neoplasmneoplasticoncooncologicovergrowthtumortumour

WordNet   license wordnet

「the pathological process that results in the formation and growth of a tumor」


typing」

  [★]

  • n.
  • タイプで打つこと、タイピング。分類


WordNet   license wordnet

「writing done with a typewriter」
typewriting




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