関: MRP

WordNet

having partial rights and privileges or subordinate status; "an associate member"; "an associate professor"
a person who joins with others in some activity or endeavor; "he had to consult his associate before continuing"
a person with subordinate membership in a society, institution, or commercial enterprise; "associates in the law firm bill at a lower rate than do partners"
any event that usually accompanies or is closely connected with another; "first was the lightning and then its thunderous associate"
make a logical or causal connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I cannot relate these events at all" (同)tie_in, relate, link, colligate, link up, connect
any mechanical force that tends to retard or oppose motion
the capacity of an organism to defend itself against harmful environmental agents; "these trees are widely planted because of their resistance to salt and smog"
the action of opposing something that you disapprove or disagree with; "he encountered a general feeling of resistance from many citizens"; "despite opposition from the newspapers he went ahead" (同)opposition
(psychiatry) an unwillingness to bring repressed feelings into conscious awareness
group action in opposition to those in power
the military action of resisting the enemys advance; "the enemy offered little resistance"
the degree of unresponsiveness of a disease-causing microorganism to antibiotics or other drugs (as in penicillin-resistant bacteria)
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"

PrepTutorEJDIC

〈人〉'を'(…の)『仲間に加える』,(…に)連合させる《+『名』〈人〉+『with』+『名』》 / (…と)…'を'結びつけて考える(起こす)《+『名』+『with』+『名』》 / (…と)『仲間になる』,交際する《+『with』+『名』》 / (…と)合体する,提携する《+『with』+『名』》 / 『仲間』,『同僚』;組合員 / 準会員 / 付属物;連想されるもの / 連合した;仲間の,同僚の / 補助の,準…
〈U〉〈C〉(…に)『抵抗』(『反抗』)『すること』;(…を)『こらえること』《+『to』(『against』)+『名』(do『ing』)》 / 〈U〉(病気などに対する)『抵抗力』《+『against』(『to』)+『名』》 / 〈U〉〈C〉(またresistance movement)(権力・圧制に対する)抵抗運動,レジスタンス / 〈U〉(空気の)抵抗;(電気の)抵抗
蛋白(たんばく)質

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/05 18:48:17」(JST)

wiki en

Multidrug resistance-associated protein 2 (MRP2) also called canalicular multispecific organic anion transporter 1 (cMOAT) or ATP-binding cassette sub-family C member 2 (ABCC2) is a protein that in humans is encoded by the ABCC2 gene.^[3]^[4]^[5]

Function

MRP2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). More specifically, this protein is a member of the MRP subfamily, which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells.

MRP2 is also expressed in on the apical membrane of proximal renal tubule endothelial cells where they are involved in the excretion of small organic anions.^[6]₳

MRP2 inhibitors

Drug	Class	Indications	Source
probenecid	uricosuric	gout hyperuricemia	^[7]
furosemide	loop diuretic	heart failure edema	^[7]
ritonavir	protease inhibitor	antiretroviral	^[8]
saquinavir	protease inhibitor	antiretroviral	^[9]
lamivudine	Nucleoside analog	antiviral	^[10]
abacavir	Nucleoside analog	antiretroviral	^[10]
emtricitabine	Nucleoside analog	antiviral	^[10]
efavirenz	NNRTI	antiretroviral	^[10]
delavirdine	NNRTI	antiretroviral	^[10]
nevirapine	NNRTI	antiretroviral	^[10]
cidofovir	nucleoside phosphonate	antiviral	^[11]
adefovir	nucleoside phosphonate	antiviral	^[9]
tenofovir	nucleoside phosphonate	antiviral	^[10]

Clinical significance

Dubin-Johnson syndrome

Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.^[5]^[12]

Iatrogenic Fanconi syndrome

Many negatively charged metabolic waste products are eliminated from the body by the kidneys. These organic anions are transported from the blood into the endothelial cells of the renal proximal tubules by the OAT1 transporter. From there, these waste molecules are transported into the lumen of the tubule by the MRP2 transporter. Many drugs are eliminated from the body by this mechanism. Some of these drugs pass through the MRP2 transporter slowly. This may cause a build up of organic anions in the cytoplasm of the cells.

Drugs that inhibit the MRP2 transporter can cause a build up of organic anions inside renal proximal tubule cells. If some of these organic anions inhibit mitochondrial DNA synthesis, it may cause iatrogenic Fanconi syndrome. The nucleoside phosphonate adefovir is a MRP2 inhibitor that has been linked to kidney disease.^[13] Tenofovir^[14] and cidofovir^[15] are also nucleoside phosphonates that inhibit MRP2 and have been associated with Fanconi syndrome.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|{{{bSize}}}px|alt=Irinotecan Pathway edit]]

File:IrinotecanPathway_WP229.png

Irinotecan Pathway edit

^ The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP46359".

References

^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ Taniguchi K, Wada M, Kohno K, Nakamura T, Kawabe T, Kawakami M, Kagotani K, Okumura K, Akiyama S, Kuwano M (Oct 1996). "A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation". Cancer Res. 56 (18): 4124–9. PMID 8797578.
^ van Kuijck MA, Kool M, Merkx GF, Geurts van Kessel A, Bindels RJ, Deen PM, van Os CH (Sep 1997). "Assignment of the canalicular multispecific organic anion transporter gene (CMOAT) to human chromosome 10q24 and mouse chromosome 19D2 by fluorescent in situ hybridization". Cytogenet Cell Genet. 77 (3-4): 285–7. doi:10.1159/000134599. PMID 9284939.
^ ^a ^b "Entrez Gene: ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2".
^ Sekine T, Miyazaki H, Endou H (February 2006). "Molecular physiology of renal organic anion transporters". Am. J. Physiol. Renal Physiol. 290 (2): F251–61. doi:10.1152/ajprenal.00439.2004. PMID 16403838.
^ ^a ^b Bakos E, Evers R, Sinkó E, Váradi A, Borst P, Sarkadi B (April 2000). "Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions". Mol. Pharmacol. 57 (4): 760–8. PMID 10727523.
^ Peyrière H, Reynes J, Rouanet I, et al. (March 2004). "Renal tubular dysfunction associated with tenofovir therapy: report of 7 cases". J. Acquir. Immune Defic. Syndr. 35 (3): 269–73. PMID 15076241.
^ ^a ^b Gimenez F, Fernandez C, Mabondzo A (June 2004). "Transport of HIV protease inhibitors through the blood–brain barrier and interactions with the efflux proteins, P-glycoprotein and multidrug resistance proteins". J. Acquir. Immune Defic. Syndr. 36 (2): 649–58. doi:10.1097/00126334-200406010-00001. PMID 15167283.
^ ^a ^b ^c ^d ^e ^f ^g Weiss J, Theile D, Ketabi-Kiyanvash N, Lindenmaier H, Haefeli WE (March 2007). "Inhibition of MRP1/ABCC1, MRP2/ABCC2, and MRP3/ABCC3 by nucleoside, nucleotide, and non-nucleoside reverse transcriptase inhibitors". Drug Metab. Dispos. 35 (3): 340–4. doi:10.1124/dmd.106.012765. PMID 17172311.
^ Miller DS (November 2001). "Nucleoside phosphonate interactions with multiple organic anion transporters in renal proximal tubule". J. Pharmacol. Exp. Ther. 299 (2): 567–74. PMID 11602668.
^ Morii, Kazuhiko; Yamamoto, Takeharu (2016-07-06). "Dubin–Johnson Syndrome". New England Journal of Medicine. 375 (1). doi:10.1056/nejmicm1509529.
^ Marcellin P, Chang TT, Lim SG, et al. (February 2003). "Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B". N. Engl. J. Med. 348 (9): 808–16. doi:10.1056/NEJMoa020681. PMID 12606735.
^ Atta MG, Fine DM (March 2009). "Editorial comment: tenofovir nephrotoxicity--the disconnect between clinical trials and real-world practice". AIDS Read. 19 (3): 118–9. PMID 19334329.
^ Vittecoq D, Dumitrescu L, Beaufils H, Deray G (August 1997). "Fanconi syndrome associated with cidofovir therapy". Antimicrob. Agents Chemother. 41 (8): 1846. PMC 164022. PMID 9257778.

External links

ABCC2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

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1. 成人の院内肺炎および人工呼吸器関連肺炎の治療 treatment of hospital acquired and ventilator associated pneumonia in adults
2. 成人の院内肺炎や人工呼吸器関連肺炎の疫学、発症機序、細菌学、診断 epidemiology pathogenesis microbiology and diagnosis of hospital acquired and ventilator associated pneumonia in adults
3. 抱合型高ビリルビン血症関連の遺伝性疾患 inherited disorders associated with conjugated hyperbilirubinemia
4. 成人におけるメチシリン耐性黄色ブドウ球菌（MRSA）：疫学 methicillin resistant staphylococcus aureus mrsa in adults epidemiology
5. 再生不良性貧血：病因、臨床症状および診断 aplastic anemia pathogenesis clinical manifestations and diagnosis

English Journal

FLT3-ITD and MLL-PTD influence the expression of MDR-1, MRP-1, and BCRP mRNA but not LRP mRNA assessed with RQ-PCR method in adult acute myeloid leukemia.

Nasilowska-Adamska B1, Solarska I, Paluszewska M, Malinowska I, Jedrzejczak WW, Warzocha K.Author information 1Institute of Hematology and Transfusion Medicine, Indiry Gandhi Str. 14, 02-776, Warsaw, Poland, barbaramail@poczta.onet.pl.AbstractFms-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) and mixed-lineage leukemia gene-partial tandem duplication (MLL-PTD) are aberrations associated with leukemia which indicate unsatisfactory prognosis. Downstream regulatory targets of FLT3-ITD and MLL-PTD are not well defined. We have analyzed the expression of MDR-1, multidrug resistant protein-1 (MRP-1), breast cancer resistance protein (BCRP), and lung resistance protein (LRP) messenger RNA (mRNA) in relation to the mutational status of FLT3-ITD and MLL-PTD in 185 acute myeloid leukemia (AML) adult patients. The real-time quantitative polymerase chain reaction method was performed to assess the expression of the MDR-1, MRP-1, BCRP, and LRP mRNA, and the results were presented as coefficients calculated using an intermediate method according to Pfaffl's rule. Significantly higher expressions of MDR-1 mRNA were found in patients who did not harbor FLT3-ITD (0.20 vs. 0.05; p = 0.0001) and MRP-1 mRNA in patients with this mutation (0.96 vs. 0.70; p = 0.002) and of BCRP mRNA in patients with MLL-PTD (0.61 vs. 0.38; p = 0.03). In univariate analysis, the high expression of MDR-1 mRNA (≥0.1317) negatively influenced the outcome of induction therapy (p = 0.05), whereas the high expression of BCRP mRNA (≥1.1487) was associated with a high relapse rate (RR) (p = 0.013). We found that the high expression of MDR-1 (≥0.1317), MRP-1 (≥0.8409), and BCRP mRNA (≥1.1487) significantly influenced disease-free survival (DFS; p = 0.059, 0.032, and 0.009, respectively) and overall survival (0.048, 0.014, and 0.059, respectively). Moreover, a high expression of BCRP mRNA (≥1.1487) proved to be an independent prognostic factor for RR (p = 0.01) and DFS (p = 0.002) in multivariate analysis. The significant correlation between the expression of MDR-1, MRP-1, and BCRP mRNA and FLT3-ITD or MLL-PTD in AML patients requires further investigation.
Annals of hematology.Ann Hematol.2014 Apr;93(4):577-93. doi: 10.1007/s00277-013-1898-7. Epub 2013 Sep 13.
Fms-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) and mixed-lineage leukemia gene-partial tandem duplication (MLL-PTD) are aberrations associated with leukemia which indicate unsatisfactory prognosis. Downstream regulatory targets of FLT3-ITD and MLL-PTD are not well defined. We have
PMID 24030729

SmeOP-TolCSm Efflux Pump Contributes to the Multidrug Resistance of Stenotrophomonas maltophilia.

Lin CW1, Huang YW, Hu RM, Yang TC.Author information 1Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan.AbstractA five-gene cluster, tolCSm-pcm-smeRo-smeO-smeP, of Stenotrophomonas maltophilia was characterized. The presence of smeOP and smeRo-pcm-tolCSm operons was verified by reverse transcription (RT)-PCR. Both operons were negatively regulated by the TetR-type transcriptional regulator SmeRo, as demonstrated by quantitative RT-PCR and a promoter-fusion assay. SmeO and SmeP were associated with TolCSm (the TolC protein of S. maltophilia) for the assembly of a resistance-nodulation-cell-division (RND)-type pump. The compounds extruded by SmeOP-TolCSm mainly included nalidixic acid, doxycycline, amikacin, gentamicin, erythromycin, leucomycin, carbonyl cyanide 3-chlorophenylhydrazone, crystal violet, sodium dodecyl sulfate, and tetrachlorosalicylanilide.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2014 Apr;58(4):2405-8. doi: 10.1128/AAC.01974-13. Epub 2014 Jan 6.
A five-gene cluster, tolCSm-pcm-smeRo-smeO-smeP, of Stenotrophomonas maltophilia was characterized. The presence of smeOP and smeRo-pcm-tolCSm operons was verified by reverse transcription (RT)-PCR. Both operons were negatively regulated by the TetR-type transcriptional regulator SmeRo, as demonstra
PMID 24395237

Copy number variation of glyoxalase I.

Shafie A, Xue M, Thornalley PJ, Rabbani N.Author information *Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, University Hospital, Coventry CV2 2DX, U.K.AbstractThe glyoxalase I gene GLO1 is a hotspot for copy number variation in the human and mouse genomes. The additional copies are often functional, giving rise to 2-4-fold increased glyoxalase I expression and activity. The prevalence of GLO1 copy number increase in the human population appears to be approximately 2% and may be linked to a risk of obesity, diabetes and aging. Increased GLO1 copy number has been found in human tumour cell lines and primary human tumours. The minimum common copy number increase region was approximately 1 Mb and it contained GLO1 and seven other genes. The increased copy number was generally functional, being associated with increased glyoxalase I protein and multidrug resistance in cancer chemotherapy. Glo1 duplication in the mouse genome is found within approximately 0.5 Mb of duplicated DNA. It was claimed to be linked to anxiety phenotypes, but other related discordant findings have doubted the association with glyoxalase I and further investigation is required.
Biochemical Society transactions.Biochem Soc Trans.2014 Apr 1;42(2):500-3. doi: 10.1042/BST20140011.
The glyoxalase I gene GLO1 is a hotspot for copy number variation in the human and mouse genomes. The additional copies are often functional, giving rise to 2-4-fold increased glyoxalase I expression and activity. The prevalence of GLO1 copy number increase in the human population appears to be appr
PMID 24646268

Japanese Journal

Caffeic Acid Inhibits the Uptake of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by Inducing the Efflux Transporters Expression in Caco-2 Cells

Hong Yun-Jin,Yang Sung-Yong,Nam Mi-Hyun [他]
Biological & pharmaceutical bulletin 38(2), 201-207, 2015-02
NAID 40020343946

Caffeic Acid Inhibits the Uptake of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by Inducing the Efflux Transporters Expression in Caco-2 Cells

, , , ,
Biological and Pharmaceutical Bulletin 38(2), 201-207, 2015
… 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is formed as a by-product of the Maillard reaction during cooking and frying of protein-rich foods at high temperatures. …
NAID 130004872242

フェキソフェナジンの立体選択的体内動態とその規定因子の解析

赤嶺由美子
薬学雑誌. 乙号 135(3), 473-481, 2015
… The findings suggested that a combination of multiple transporters involving organic anion transporting polypeptide (OATP) 2B1, P-glycoprotein (P-gp), and multidrug resistance-associated protein 2 (MRP2) react to stereoselective fexofenadine exposure. …
NAID 130004756523

「多剤耐性関連タンパク質」

ABCC2
Identifiers
Aliases	ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP, Multidrug resistance-associated protein 2, ATP binding cassette subfamily C member 2
External IDs	MGI: 1352447 HomoloGene: 68052 GeneCards: 1244
Gene ontology
Molecular function	• ATPase activity; • nucleotide binding; • protein binding; • ATP binding; • transporter activity; • protein domain specific binding; • ATPase activity, coupled to transmembrane movement of substances; • organic anion transmembrane transporter activity; • anion transmembrane-transporting ATPase activity; • bilirubin transmembrane transporter activity;
Cellular component	• integral component of membrane; • membrane; • cell surface; • plasma membrane; • integral component of plasma membrane; • apical plasma membrane;
Biological process	• response to steroid hormone; • response to arsenic-containing substance; • response to drug; • prostaglandin transport; • response to methotrexate; • thyroid hormone transport; • drug transmembrane transport; • transmembrane transport; • cellular chloride ion homeostasis; • response to oxidative stress; • response to estrogen; • response to heat; • transport; • bilirubin transport; • anion transmembrane transport;
	Sources:Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	1244
	12780
	ENSG00000023839
	ENSMUSG00000025194
	Q92887
	Q8VI47
	NM_000392
	NM_013806
	NP_000383.1
	NP_038834.2
	Wikidata
View/Edit Human	View/Edit Mouse

　　[★]

英: multidrug resistance-associated protein、MRP

「associate」

　　[★]

vt.

結合する、連合させる。連想によって結びつける。(人を)仲間/友達などとしての関係に置く。(化)会合させる

vi.

仲間/友人などとして交際する(with)。一つにまとめる、連合する

n.

仕事仲間、提携者、同僚。友人、朋友。準会員。従業員、社員
密接な蒸す偽付きのある物、付随する物、つきもの。準国家
連想によって心に浮かぶ言葉/思い、連想物

adj.

仲間の、同僚の。製紙機械員に次ぐ資格の
付随する、連想される

関: accompany、association、associative、attach、bearing、bind、binding、bond、bonding、coassemble、colleague、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、correlate、correlation、couple、dock、engage、engagement、federation、implication、join、joint、ligate、link、linkage、peer、pertinent、reference、relate、relation、relationship、relative、relevance、relevant、symphysial、union

「associated」

　　[★]

adj.

随伴の、随伴性の

関: concomitant、erratic、erratically; associate

「multidrug」

　　[★]

多剤の、多種薬剤の

関: multiagent、multiple drug、polydrug

「multidrug resistance」

　　[★] 多剤耐性

同: MDR
関: drug resistance

「associated protein」

　　[★]

関連タンパク質

関: related protein

[WikiPathways-16] The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP46359".

[1] "Human PubMed Reference:".

[2] "Mouse PubMed Reference:".

[pmid8797578-3] Taniguchi K, Wada M, Kohno K, Nakamura T, Kawabe T, Kawakami M, Kagotani K, Okumura K, Akiyama S, Kuwano M (Oct 1996). "A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation". Cancer Res. 56 (18): 4124–9. PMID 8797578.

[pmid9284939-4] van Kuijck MA, Kool M, Merkx GF, Geurts van Kessel A, Bindels RJ, Deen PM, van Os CH (Sep 1997). "Assignment of the canalicular multispecific organic anion transporter gene (CMOAT) to human chromosome 10q24 and mouse chromosome 19D2 by fluorescent in situ hybridization". Cytogenet Cell Genet. 77 (3-4): 285–7. doi:10.1159/000134599. PMID 9284939.

[entrez-5] "Entrez Gene: ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2".

[pmid16403838-6] Sekine T, Miyazaki H, Endou H (February 2006). "Molecular physiology of renal organic anion transporters". Am. J. Physiol. Renal Physiol. 290 (2): F251–61. doi:10.1152/ajprenal.00439.2004. PMID 16403838.

[pmid10727523-7] Bakos E, Evers R, Sinkó E, Váradi A, Borst P, Sarkadi B (April 2000). "Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions". Mol. Pharmacol. 57 (4): 760–8. PMID 10727523.

[pmid15076241-8] Peyrière H, Reynes J, Rouanet I, et al. (March 2004). "Renal tubular dysfunction associated with tenofovir therapy: report of 7 cases". J. Acquir. Immune Defic. Syndr. 35 (3): 269–73. PMID 15076241.

[pmid15167283-9] Gimenez F, Fernandez C, Mabondzo A (June 2004). "Transport of HIV protease inhibitors through the blood–brain barrier and interactions with the efflux proteins, P-glycoprotein and multidrug resistance proteins". J. Acquir. Immune Defic. Syndr. 36 (2): 649–58. doi:10.1097/00126334-200406010-00001. PMID 15167283.

[pmid17172311-10] ^ ^a ^b ^c ^d ^e ^f ^g Weiss J, Theile D, Ketabi-Kiyanvash N, Lindenmaier H, Haefeli WE (March 2007). "Inhibition of MRP1/ABCC1, MRP2/ABCC2, and MRP3/ABCC3 by nucleoside, nucleotide, and non-nucleoside reverse transcriptase inhibitors". Drug Metab. Dispos. 35 (3): 340–4. doi:10.1124/dmd.106.012765. PMID 17172311.

[pmid11602668-11] Miller DS (November 2001). "Nucleoside phosphonate interactions with multiple organic anion transporters in renal proximal tubule". J. Pharmacol. Exp. Ther. 299 (2): 567–74. PMID 11602668.

[12] Morii, Kazuhiko; Yamamoto, Takeharu (2016-07-06). "Dubin–Johnson Syndrome". New England Journal of Medicine. 375 (1). doi:10.1056/nejmicm1509529.

[pmid12606735-13] Marcellin P, Chang TT, Lim SG, et al. (February 2003). "Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B". N. Engl. J. Med. 348 (9): 808–16. doi:10.1056/NEJMoa020681. PMID 12606735.

[pmid19334329-14] Atta MG, Fine DM (March 2009). "Editorial comment: tenofovir nephrotoxicity--the disconnect between clinical trials and real-world practice". AIDS Read. 19 (3): 118–9. PMID 19334329.

[pmid9257778-15] Vittecoq D, Dumitrescu L, Beaufils H, Deray G (August 1997). "Fanconi syndrome associated with cidofovir therapy". Antimicrob. Agents Chemother. 41 (8): 1846. PMC 164022. PMID 9257778.

v t e Membrane proteins, carrier proteins: membrane transport proteins ABC-transporter (TC 3A1)

A	A1 A2 A3 A4 A7 A8 A12 A13

B	B1 B2-3 (B2 B3) B4 B5 B6 B7 B9 B11

C	C1 C2 C3 C4 C5 C6 C7 C8-9 (C8, C9) C10 C11 C13

D	D1 D2 D3 D4

E	E1

F	F1 F2

G	G1 G2 G4 Sterolin (G5, G8)

see also ABC transporter disorders

リンク元	「多剤耐性関連タンパク質」
関連記事	「associate」「associated」「multidrug」「multidrug resistance」「associated protein」

匿名

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案内

案内

multidrug resistance-associated protein