mtTFA

Transcription factor A, mitochondrial
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	3FGH, 3TMM, 3TQ6, 4NNU, 4NOD
Identifiers
Symbols	TFAM ; MTTF1; MTTFA; TCF6; TCF6L1; TCF6L2; TCF6L3
External IDs	OMIM: 600438 MGI: 107810 HomoloGene: 31139 GeneCards: TFAM Gene
Gene ontology
Molecular function	• chromatin binding; • sequence-specific DNA binding transcription factor activity; • protein binding; • DNA binding, bending; • heat shock protein binding; • poly(A) RNA binding; • mitochondrial light strand promoter sense binding;
Cellular component	• nucleus; • mitochondrion; • mitochondrial matrix; • mitochondrial nucleoid;
Biological process	• DNA-dependent DNA replication; • regulation of transcription from RNA polymerase I promoter; • transcription from mitochondrial promoter; • transcription initiation from mitochondrial promoter; • gene expression; • mitochondrial respiratory chain complex assembly; • positive regulation of transcription, DNA-templated;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/25 19:47:15」(JST)

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[Wiki en表示]

Mitochondrial transcription factor A, abbreviated as TFAM or mtTFA, is a protein that in humans is encoded by the TFAM gene.^[1]^[2]

Function

This gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. TFAM bends mitochondrial promoter DNA to aid transcription of the mitochondrial genome. Studies in mice have demonstrated that this gene product is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns-Sayre syndrome was produced when expression of this gene was eliminated by targeted disruption in heart and muscle cells.^[2]

Interactions

TFAM has been shown to interact with TFB1M.^[3]

References

^ Tiranti V, Rossi E, Ruiz-Carrillo A, Rossi G, Rocchi M, DiDonato S et al. (Jul 1995). "Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis". Genomics 25 (2): 559–64. doi:10.1016/0888-7543(95)80058-T. PMID 7789991.
^ ^a ^b "Entrez Gene: TFAM transcription factor A, mitochondrial".
^ McCulloch V, Shadel GS (Aug 2003). "Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity". Mol. Cell. Biol. 23 (16): 5816–24. doi:10.1128/MCB.23.16.5816-5824.2003. PMC 166325. PMID 12897151.

English Journal

Nuclear factor erythroid-derived 2-like 2 (NFE2L2, Nrf2) mediates exercise-induced mitochondrial biogenesis and the anti-oxidant response in mice.

Merry TL1,2, Ristow M3.
The Journal of physiology.J Physiol.2016 Sep 15;594(18):5195-207. doi: 10.1113/JP271957. Epub 2016 May 27.
KEY POINTS: Reactive oxygen species (ROS) and nitric oxide (NO) regulate exercise-induced nuclear factor erythroid 2-related factor 2 (NFE2L2) expression in skeletal muscle. NFE2L2 is required for acute exercise-induced increases in skeletal muscle mitochondrial biogenesis genes, such as nuclear res
PMID 27094017

T-2 toxin inhibits murine ES cells cardiac differentiation and mitochondrial biogenesis by ROS and p-38 MAPK-mediated pathway.

Fang H1, Cong L2, Zhi Y3, Xu H3, Jia X4, Peng S5.
Toxicology letters.Toxicol Lett.2016 Sep 6;258:259-66. doi: 10.1016/j.toxlet.2016.06.2103. Epub 2016 Jun 27.
OBJECTIVE: To investigate the effect of T-2 toxin on murine embryonic stem cells (ESCs) cardiac differentiation and mitochondrial biogenesis in vitro.METHODS: Cardiac differentiation of the mouse ESCs was initiated by embryoid bodies (EBs) formation in hanging drops. EBs were exposed to 0.5ng/ml T-2
PMID 27363784

Japanese Journal

Protective Effect of Demethylation Treatment on Cigarette Smoke Extract–Induced Mouse Emphysema Model

Zhang Hongliang,Chen Ping,Zeng Huihui,Zhang Yan,Peng Hong,Chen Yan,He Zhihui
Journal of Pharmacological Sciences 123(2), 159-166, 2013
… The mitochondrial transcription factor A (mtTFA) promoter methylation increased over 4-fold in the CSE group compared with the control group, which was reversed by AZA. … The mtTFA and the cytochrome c oxidase subunit II (COX II) mRNA and protein levels were decreased approximately 3-fold in the CSE group compared with the control group, which was largely restored by AZA. …
NAID 130003382587

PS-148-6 膵癌におけるmitochondrialtranscription factor A(mtTFA)発現についての検討 : 予後因子としての可能性(PS-148 膵基礎-2,ポスターセッション,第112回日本外科学会定期学術集会)

山内潤身,皆川紀剛,井上譲,金光秀一,中山善文,山口幸二
日本外科学会雑誌 113(臨時増刊号_2), 788, 2012-03-05
NAID 110009549877

Related Pictures

[pmid7789991-1] Tiranti V, Rossi E, Ruiz-Carrillo A, Rossi G, Rocchi M, DiDonato S et al. (Jul 1995). "Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis". Genomics 25 (2): 559–64. doi:10.1016/0888-7543(95)80058-T. PMID 7789991.

[entrez-2] "Entrez Gene: TFAM transcription factor A, mitochondrial".

[pmid12897151-3] McCulloch V, Shadel GS (Aug 2003). "Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity". Mol. Cell. Biol. 23 (16): 5816–24. doi:10.1128/MCB.23.16.5816-5824.2003. PMC 166325. PMID 12897151.

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