モキシシリト、モキシシリート
- 関
- moxisylyte hydrochloride
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/06/13 15:46:19」(JST)
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Moxisylyte
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Clinical data |
AHFS/Drugs.com |
International Drug Names |
ATC code |
- G04BE06 (WHO) C04AX10 (WHO)
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Identifiers |
IUPAC name
- 4-[2-(Dimethylamino)ethoxy]-5-isopropyl-2-methylphenyl acetate
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CAS Number |
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PubChem CID |
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ChemSpider |
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UNII |
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KEGG |
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ECHA InfoCard |
100.000.186 |
Chemical and physical data |
Formula |
C16H25NO3 |
Molar mass |
279.375 g/mol |
3D model (Jmol) |
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SMILES
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CC1=CC(=C(C=C1OC(=O)C)C(C)C)OCCN(C)C
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InChI
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InChI=1S/C16H25NO3/c1-11(2)14-10-15(20-13(4)18)12(3)9-16(14)19-8-7-17(5)6/h9-11H,7-8H2,1-6H3
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Key:VRYMTAVOXVTQEF-UHFFFAOYSA-N
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(verify) |
Moxisylyte, also known as thymoxamine, is a drug used in urology for the treatment of erectile dysfunction.[1] It is an α1-adrenergic antagonist.[2] In the United Kingdom, Moxisylte is marketed as Opilon (Archimedes Pharma UK Ltd) and is used for the short-term treatment of primary Reynaud's syndrome. This is a condition where the fingers and toes become discoloured and is triggered by responses to cold, or emotional distress. Opilon tablets help by improving blood circulation to the extremities.[3][4]
References
- ^ British National Formulary 69, Chapter2.6.4, page 142
- ^ Sakakibara R, Hattori T, Uchiyama T, et al. (March 2000). "Are alpha-blockers involved in lower urinary tract dysfunction in multiple system atrophy? A comparison of prazosin and moxisylyte". J. Auton. Nerv. Syst. 79 (2–3): 191–5. PMID 10699651. doi:10.1016/S0165-1838(99)00105-8.
- ^ British National Formulary 70, page 205
- ^ https://www.medicines.org.uk/emc/medicine/18240
Peripheral vasodilators (C04)
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Phenylethanolamine derivatives |
- Isoxsuprine
- Buphenine
- Bamethan
|
Alpha blockers |
- Non-selective
- Selective α1-blockers
- Alfuzosin
- Doxazosin
- Prazosin
- Silodosin
- Tamsulosin
- Terazosin
|
Niacin and derivatives |
- Niacin
- Nicotinyl alcohol
- Inositol nicotinate
- Ciclonicate
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Purine derivatives |
- Pentifylline
- Xantinol nicotinate
- Pentoxifylline
- Etofylline nicotinate
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Ergot alkaloids |
- Ergoloid
- Nicergoline
- Dihydroergocristine
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Other peripheral vasodilators |
- Cyclandelate
- Phenoxybenzamine
- Vincamine
- Moxisylyte
- Bencyclane
- Vinburnine
- Sulcotidil
- Buflomedil
- Naftidrofuryl
- Butalamine
- Visnadine
- Cetiedil
- Cinepazide
- Ifenprodil
- Azapetine
- Fasudil
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Drugs for erectile dysfunction (G04BE) and premature ejaculation
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For erectile dysfunction |
Prostaglandins (E) |
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PDE5 inhibitors |
- Avanafil
- Sildenafil
- Tadalafil
- Udenafil
- Vardenafil
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Alpha blockers |
- Moxisylyte
- Phentolamine
- Yohimbine
|
Dopamine agonists |
|
Melanocortin agonists |
- Bremelanotide
- Melanotan II
- PL-6983
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Others |
- Afrodor (acecarbromal, quebracho, vitamin E)
- Papaverine
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|
For premature ejaculation |
SSRIs |
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Oxytocin antagonists |
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DRA/DRIs |
- Amphetamine
- Methamphetamine
- Methylphenidate
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|
- See also: Sexual dysfunction pharmacotherapies
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Adrenergic receptor modulators
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α1 |
- Agonists
- 6-FNE
- Amidephrine
- Anisodine
- Buspirone
- Cirazoline
- Corbadrine
- Desglymidodrine
- Dexisometheptene
- Dipivefrine
- Dopamine
- Droxidopa (L-DOPS)
- Ephedrine
- Epinephrine
- Etilefrine
- Etilevodopa
- Ethylnorepinephrine
- Indanidine
- Isometheptene
- L-DOPA (levodopa)
- L-Phenylalanine
- L-Tyrosine
- Melevodopa
- Metaraminol
- Methoxamine
- Methyldopa
- Midodrine
- Naphazoline
- Norepinephrine
- Octopamine (drug)
- Oxymetazoline
- Phenylephrine
- Phenylpropanolamine
- Pseudoephedrine
- Synephrine
- Tetryzoline
- Tiamenidine
- XP21279
- Xylometazoline
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- Antagonists
- Abanoquil
- Adimolol
- Ajmalicine
- Alfuzosin
- Amosulalol
- Anisodamine
- Arotinolol
- Atiprosin
- Atypical antipsychotics (e.g., clozapine, olanzapine, quetiapine, risperidone)
- Benoxathian
- Buflomedil
- Bunazosin
- Carvedilol
- Corynanthine
- Dapiprazole
- Domesticine
- Doxazosin
- Ergolines (e.g., ergotamine, dihydroergotamine, lisuride, terguride)
- Etoperidone
- Eugenodilol
- Fenspiride
- Hydroxyzine
- Indoramin
- Ketanserin
- L-765,314
- Labetalol
- mCPP
- Mepiprazole
- Metazosin
- Monatepil
- Moxisylyte
- Naftopidil
- Nantenine
- Nefazodone
- Neldazosin
- Niaprazine
- Nicergoline
- Niguldipine
- Pardoprunox
- Pelanserin
- Phendioxan
- Phenoxybenzamine
- Phentolamine
- Piperoxan
- Prazosin
- Quinazosin
- Ritanserin
- Silodosin
- Spiperone
- Talipexole
- Tamsulosin
- Terazosin
- Tiodazosin
- Tolazoline
- Trazodone
- Tetracyclic antidepressants (e.g., amoxapine, maprotiline, mianserin)
- Tricyclic antidepressants (e.g., amitriptyline, clomipramine, doxepin, imipramine, trimipramine)
- Trimazosin
- Typical antipsychotics (e.g., chlorpromazine, fluphenazine, loxapine, thioridazine)
- Urapidil
- WB-4101
- Zolertine
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α2 |
- Agonists
- (R)-3-Nitrobiphenyline
- 4-NEMD
- 6-FNE
- Amitraz
- Apraclonidine
- Brimonidine
- Cannabivarin
- Clonidine
- Corbadrine
- Detomidine
- Dexmedetomidine
- Dihydroergotamine
- Dipivefrine
- Dopamine
- Droxidopa (L-DOPS)
- Etilevodopa
- Ephedrine
- Ergotamine
- Epinephrine
- Etilefrine
- Ethylnorepinephrine
- Guanabenz
- Guanfacine
- Guanoxabenz
- L-DOPA (levodopa)
- L-Phenylalanine
- L-Tyrosine
- Lofexidine
- Medetomidine
- Melevodopa
- Methyldopa
- Mivazerol
- Naphazoline
- Norepinephrine
- Oxymetazoline
- Phenylpropanolamine
- Piperoxan
- Pseudoephedrine
- Rezatomidine
- Rilmenidine
- Romifidine
- Talipexole
- Tetrahydrozoline
- Tiamenidine
- Tizanidine
- Tolonidine
- Urapidil
- XP21279
- Xylazine
- Xylometazoline
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- Antagonists
- 1-PP
- Adimolol
- Aptazapine
- Atipamezole
- Atypical antipsychotics (e.g., asenapine, clozapine, lurasidone, paliperidone, quetiapine, risperidone, zotepine)
- Azapirones (e.g., buspirone, tandospirone)
- BRL-44408
- Buflomedil
- Cirazoline
- Efaroxan
- Esmirtazapine
- Fenmetozole
- Fluparoxan
- Idazoxan
- mCPP
- Mianserin
- Mirtazapine
- NAN-190
- Olanzapine
- Pardoprunox
- Phentolamine
- Phenoxybenzamine
- Piperoxan
- Piribedil
- Rauwolscine
- Rotigotine
- SB-269970
- Setiptiline
- Spiroxatrine
- Sunepitron
- Tolazoline
- Typical antipsychotics (e.g., chlorpromazine, fluphenazine, loxapine, thioridazine)
- Yohimbine
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|
β |
- Agonists
- Abediterol
- Alifedrine
- Amibegron
- Arbutamine
- Arformoterol
- Arotinolol
- BAAM
- Bambuterol
- Befunolol
- Bitolterol
- Broxaterol
- Buphenine
- Carbuterol
- Carmoterol
- Cimaterol
- Clenbuterol
- Corbadrine
- Denopamine
- Dipivefrine
- Dobutamine
- Dopamine
- Dopexamine
- Droxidopa (L-DOPS)
- Ephedrine
- Epinephrine
- Etafedrine
- Etilefrine
- Etilevodopa
- Ethylnorepinephrine
- Fenoterol
- Formoterol
- Hexoprenaline
- Higenamine
- Indacaterol
- Isoetarine
- Isoprenaline
- Isoxsuprine
- L-DOPA (levodopa)
- L-Phenylalanine
- L-Tyrosine
- Levosalbutamol
- Mabuterol
- Melevodopa
- Methoxyphenamine
- Methyldopa
- Mirabegron
- Norepinephrine
- Orciprenaline
- Oxyfedrine
- PF-610355
- Phenylpropanolamine
- Pirbuterol
- Prenalterol
- Ractopamine
- Procaterol
- Pseudoephedrine
- Reproterol
- Rimiterol
- Ritodrine
- Salbutamol
- Salmeterol
- Solabegron
- Terbutaline
- Tretoquinol
- Tulobuterol
- Vilanterol
- Xamoterol
- XP21279
- Zilpaterol
- Zinterol
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- Antagonists
- Acebutolol
- Adaprolol
- Adimolol
- Afurolol
- Alprenolol
- Alprenoxime
- Amosulalol
- Ancarolol
- Arnolol
- Arotinolol
- Atenolol
- Befunolol
- Betaxolol
- Bevantolol
- Bisoprolol
- Bopindolol
- Bornaprolol
- Brefonalol
- Bucindolol
- Bucumolol
- Bufetolol
- Bufuralol
- Bunitrolol
- Bunolol
- Bupranolol
- Butaxamine
- Butidrine
- Butofilolol
- Capsinolol
- Carazolol
- Carpindolol
- Carteolol
- Carvedilol
- Celiprolol
- Cetamolol
- Cicloprolol
- Cinamolol
- Cloranolol
- Cyanopindolol
- Dalbraminol
- Dexpropranolol
- Diacetolol
- Dichloroisoprenaline
- Dihydroalprenolol
- Dilevalol
- Diprafenone
- Draquinolol
- Ecastolol
- Epanolol
- Ericolol
- Ersentilide
- Esatenolol
- Esprolol
- Eugenodilol
- Exaprolol
- Falintolol
- Flestolol
- Flusoxolol
- Hydroxycarteolol
- Hydroxytertatolol
- ICI-118,551
- Idropranolol
- Indenolol
- Indopanolol
- Iodocyanopindolol
- Iprocrolol
- Isoxaprolol
- Isamoltane
- Labetalol
- Landiolol
- Levobetaxolol
- Levobunolol
- Levomoprolol
- Medroxalol
- Mepindolol
- Metipranolol
- Metoprolol
- Moprolol
- Nadolol
- Nadoxolol
- Nebivolol
- Nifenalol
- Nipradilol
- Oxprenolol
- Pacrinolol
- Pafenolol
- Pamatolol
- Pargolol
- Penbutolol
- Pindolol
- Practolol
- Primidolol
- Procinolol
- Pronethalol
- Propafenone
- Propranolol
- Ridazolol
- Ronactolol
- Soquinolol
- Sotalol
- Spirendolol
- SR 59230A
- Sulfinalol
- Talinolol
- Tazolol
- Tertatolol
- Tienoxolol
- Tilisolol
- Timolol
- Tiprenolol
- Tolamolol
- Toliprolol
- Xibenolol
- Xipranolol
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- See also: Receptor/signaling modulators
- Dopaminergics
- Serotonergics
- Monoamine reuptake inhibitors
- Monoamine releasing agents
- Monoamine metabolism modulators
- Monoamine neurotoxins
|
English Journal
- Butendieck RR1, Murray PM2.
- The Journal of hand surgery.J Hand Surg Am.2014 Jan;39(1):121-4. doi: 10.1016/j.jhsa.2013.08.117. Epub 2013 Nov 6.
- PMID 24211176
- Oral vasodilators for primary Raynaud's phenomenon.
- Stewart M1, Morling JR.
- The Cochrane database of systematic reviews.Cochrane Database Syst Rev.2012 Jul 11;(7):CD006687. doi: 10.1002/14651858.CD006687.pub3.
- BACKGROUND: Many different drugs have been suggested for the symptomatic treatment of primary Raynaud's phenomenon. Apart from calcium channel blockers, which are considered the drugs of choice, the evidence of the effects of alternative pharmacological treatments is limited. This is an update of a
- PMID 22786498
- Raynaud's phenomenon (primary).
- Pope JE1.
- BMJ clinical evidence.BMJ Clin Evid.2011 Mar 14;2011. pii: 1119.
- INTRODUCTION: Raynaud's phenomenon is an episodic vasospasm of the peripheral arteries, causing pallor, followed by cyanosis and redness with pain, and sometimes paraesthesia. On rare occasions it can lead to ulceration of the fingers and toes (and in some cases of the ears or nose). This review foc
- PMID 21401971
Japanese Journal
- High-performance liquid chromatographic determination of the conjugate metabolites of moxisylyte in human plasma and urine
- Journal of chromatography. B, Biomedical sciences and applications 691(2), 389-396, 1997-04-11
- NAID 10024513765
- Moxisylyteの下部尿路系に対する作用―2 生体位尿道に対する作用
- Moxisylyteの下部尿路系に対する作用―1 摘出ウサギ尿道およびぼうこうに対する作用
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- moxisylyte、moxisylyte hydrochloride
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- モキシシリート、塩酸モキシシリト
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- 英
- moxisylyte
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- moxisylyte