Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/17 08:58:41」(JST)

Moxaverine is a drug used to treat functional gastrointestinal disorders.

It is a phosphodiesterase inhibitor.^[1]

References

^ Mannhold R (December 1988). "Inhibition of calmodulin dependent c-AMP-phosphodiesterase by moxaverine and papaverine". Arzneimittelforschung 38 (12): 1806–8. PMID 2854468.

This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it.

Rh(iii)-catalyzed C-H activation/cyclization of oximes with alkenes for regioselective synthesis of isoquinolines.

Chen R1, Qi J, Mao Z, Cui S.
Organic & biomolecular chemistry.Org Biomol Chem.2016 Jul 14;14(26):6201-4. doi: 10.1039/c6ob00942e. Epub 2016 Jun 8.
A Rh(iii)-catalyzed C-H activation/cyclization of oximes and alkenes for facile and regioselective access to isoquinolines has been developed. This protocol features mild reaction conditions and easily accessible starting materials, and has been applied to the concise synthesis of moxaverine. A kine
PMID 27273816

Update on current and future novel therapies for dry age-related macular degeneration.

Leung E1, Landa G.
Expert review of clinical pharmacology.Expert Rev Clin Pharmacol.2013 Sep;6(5):565-79. doi: 10.1586/17512433.2013.829645. Epub 2013 Aug 24.
Age-related macular degeneration (ARMD) is the leading cause of irreversible blindness in developed countries. There are currently no cures, but there are promising potential therapies that target the underlying disease mechanisms of dry ARMD. Stem cells, ciliary neurotrophic factor, rheopheresis, o
PMID 23971874

Effects of orally administered moxaverine on ocular blood flow in healthy subjects.

Schmidl D1, Pemp B, Lasta M, Boltz A, Kaya S, Palkovits S, Prager F, Schmetterer L, Garhofer G.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie.Graefes Arch Clin Exp Ophthalmol.2013 Feb;251(2):515-20. doi: 10.1007/s00417-012-2207-1. Epub 2012 Dec 1.
BACKGROUND: To investigate the effect of orally administered moxaverine (Kollateral forte®) on ocular blood flow in young healthy subjects.METHODS: Sixteen healthy subjects (eight male/eight female) aged between 20 and 32 years were included in this placebo-controlled, double-masked, two-way crosso
PMID 23203292

Moxaverine
Systematic (IUPAC) name
	1-benzyl-3-ethyl-6,7-dimethoxyisoquinoline
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	10539-19-2
ATC code	A03AD30
PubChem	CID: 70882
ChemSpider	64045
UNII	P3P08Y1XJ4
KEGG	D07089
Chemical data
Formula	C20H21NO2
Molecular mass	307.386 g/mol
	SMILES CCC1=NC(=C2C=C(C(=CC2=C1)OC)OC)CC3=CC=CC=C3 ;
	InChI InChI=1S/C20H21NO2/c1-4-16-11-15-12-19(22-2)20(23-3)13-17(15)18(21-16)10-14-8-6-5-7-9-14/h5-9,11-13H,4,10H2,1-3H3 ; Key:MYCMTMIGRXJNSO-UHFFFAOYSA-N ;
(verify)