morphine receptor

オピオイド受容体

WordNet

1. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
2. an alkaloid narcotic drug extracted from opium; a powerful, habit-forming narcotic used to relieve pain (同)morphia

PrepTutorEJDIC

1. =sense organ / 受信装置
2. モルヒネ(鎮痛・麻酔剤)

UpToDate Contents

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• 1. 危篤状態の成人患者における疼痛管理 pain control in the critically ill adult patient
• 2. オピオイド系薬剤を用いた癌疼痛のマネージメント：至適鎮痛作用 cancer pain management with opioids optimizing analgesia
• 3. Management of acute perioperative pain
• 4. 周術期の投薬マネージメント perioperative medication management
• 5. 小児および思春期におけるオピオイド中毒 opioid intoxication in children and adolescents

English Journal

• Opioids and TRPV1 in the peripheral control of neuropathic pain - Defining a target site in the injured nerve.

• Labuz D1, Spahn V2, Celik MÖ3, Machelska H4.
• Neuropharmacology.Neuropharmacology.2016 Feb;101:330-40. doi: 10.1016/j.neuropharm.2015.10.003. Epub 2015 Oct 8.
• Targeting peripheral neuropathic pain at its origin may prevent the development of hypersensitivity. Recently we showed this can be mediated by opioid receptors at the injured nerve trunk. Here, we searched for the most relevant peripheral site to block transient receptor potential vanilloid 1 (TRPV
• PMID 26453963

• Activation of serotonin 5-HT2C receptor suppresses behavioral sensitization and naloxone-precipitated withdrawal symptoms in morphine-dependent mice.

• Zhang G1, Wu X2, Zhang YM3, Liu H2, Jiang Q2, Pang G2, Tao X4, Dong L2, Stackman RW Jr5.
• Neuropharmacology.Neuropharmacology.2016 Feb;101:246-54. doi: 10.1016/j.neuropharm.2015.09.031. Epub 2015 Dec 3.
• Opioid abuse and dependence have evolved into an international epidemic as a significant clinical and societal problem with devastating consequences. Repeated exposure to the opioid, for example morphine, can induce profound, long-lasting behavioral sensitization and physical dependence, which are t
• PMID 26432939

• Opiorphin causes a panicolytic-like effect in rat panic models mediated by μ-opioid receptors in the dorsal periaqueductal gray.

• Maraschin JC1, Rangel MP2, Bonfim AJ2, Kitayama M2, Graeff FG3, Zangrossi H Jr4, Audi EA5.
• Neuropharmacology.Neuropharmacology.2016 Feb;101:264-70. doi: 10.1016/j.neuropharm.2015.09.008. Epub 2015 Sep 10.
• Reported evidence indicates that endogenous opioid peptides regulate the expression of escape behavior in rats, a panic-related defensive response, through μ-opioid receptors (MORs) in the dorsal periaqueductal gray (dPAG). These peptides are rapidly catabolized by degrading enzymes, including neut
• PMID 26363194

Japanese Journal

• Attenuation of morphine antinociceptive tolerance by cannabinoid CB1 and CB2 receptor antagonists

• The journal of physiological sciences 65(5), 407-415, 2015-09
• NAID 40020576513

• 神経障害性疼痛下における薬物トランスポーターの発現とモルヒネの鎮痛効果の変動

• 薬学雑誌. 乙号 135(5), 703-708, 2015
• NAID 130005066921

• Potential Involvement of μ-Opioid Receptor Dysregulation on the Reduced Antinociception of Morphine in the Inflammatory Pain State in Mice

• Journal of pharmacological sciences 124(2), 258-266, 2014-02
• NAID 40019992687

Related Links

• Morphine-Induced μ-Opioid Receptor Desensitization

Morphine has been widely accepted as the opioid agonist that sustains signaling because it does not cause receptor desensitization or internalization. This notion has led to the hypothesis that long-term morphine treatment initiates ...

• Morphine receptors in immunocytes and neurons.

1. Adv Neuroimmunol. 1994;4(2):69-82. Morphine receptors in immunocytes and neurons. Makman MH. Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461. Receptor interactions of morphine are ...

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★リンクテーブル★

リンク元	「オピオイド受容体」「モルヒネ受容体」

「オピオイド受容体」

　　[★]

英

opioid receptor

同

モルヒネ受容体 morphine receptor

関

オピオイドペプチド、オピオイド

• オピオイド受容体はμ受容体、κ受容体、δ受容体がある。
• モルヒネ、フェンタニルはμ受容体刺激薬
• 呼吸抑制はμ₂受容体を介したものである。

オピオイドとオピオイド受容体 (GOO.552)

	μ受容体	δ受容体	κ受容体
薬物
モルフィン	+++		+
フェンタニル	+++
ブトルファノール	P		+++
ブプレノルフィン	P		－－
ナロキソン	－－－	－	－－
ナロルフィン	－－－		+
内因性オピオイドペプチド
Met-エンケファリン	++	+++
Leu-エンケファリン	++	+++
β-エンドルフィン	+++	+++
ダイノルフィンA	++		+++
ダイノルフィンB	+	+	+++

オピオイド受容体の生理作用(周術期管理学 091211 III)

受容体	μ		δ	κ
	μ1	μ2
作用	鎮痛	鎮痛	鎮痛	鎮痛
	悪心・嘔吐	鎮静	鎮静	身体依存
	多幸感	呼吸抑制	身体違和感	精神依存
	掻痒感	身体依存	気分不快	呼吸抑制
	縮瞳	精神依存	興奮
	尿閉	消化器運動抑制	幻覚
		鎮咳	鎮咳
			呼吸抑制
			縮瞳
			利尿

身体依存性

• 痛みがある人には精神的依存はきたさない(痛みの有無によらず退薬現象はある)

「モルヒネ受容体」

　　[★]

英

morphine receptor

同

オピオイド受容体、アヘン類受容体