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- 1. クリプトコッカス・ガッティ感染症：微生物学、疫学、および病因 cryptococcus gattii infection microbiology epidemiology and pathogenesis
- 2. 抗酸菌易感染性を示すメンデル型遺伝性疾患：概要 mendelian susceptibility to mycobacterial diseases an overview
- 3. 抗酸菌易感染性を示すメンデル型遺伝性疾患：特異的な遺伝子異常 mendelian susceptibility to mycobacterial diseases specific defects
- 4. 新生児の免疫 immunity of the newborn
- 5. ピロリン酸カルシウム結晶沈着症（CPPD）の発症および病因 pathogenesis and etiology of calcium pyrophosphate crystal deposition cppd disease
- Surface code-biophysical signals for apoptotic cell clearance.
- Biermann M, Maueröder C, Brauner JM, Chaurio R, Janko C, Herrmann M, Muñoz LE.Author information Friedrich-Alexander Universität, Department of Internal Medicine 3-Rheumatology and Immunology, D-91054 Erlangen, Germany.AbstractApoptotic cell death and the clearance of dying cells play an important and physiological role in embryonic development and normal tissue turnover. In contrast to necrosis, apoptosis proceeds in an anti-inflammatory manner. It is orchestrated by the timed release and/or exposure of so-called 'find-me', 'eat me' and 'tolerate me' signals. Mononuclear phagocytes are attracted by various 'find-me' signals, including proteins, nucleotides, and phospholipids released by the dying cell, whereas the involvement of granulocytes is prevented via 'stay away' signals. The exposure of anionic phospholipids like phosphatidylserine (PS) by apoptotic cells on the outer leaflet of the plasma membrane is one of the main 'eat me' signals. PS is recognized by a number of innate receptors as well as by soluble bridging molecules on the surface of phagocytes. Importantly, phagocytes are able to discriminate between viable and apoptotic cells both exposing PS. Due to cytoskeleton remodeling PS has a higher lateral mobility on the surfaces of apoptotic cells thereby promoting receptor clustering on the phagocyte. PS not only plays an important role in the engulfment process, but also acts as 'tolerate me' signal inducing the release of anti-inflammatory cytokines by phagocytes. An efficient and fast clearance of apoptotic cells is required to prevent secondary necrosis and leakage of intracellular danger signals into the surrounding tissue. Failure or prolongation of the clearance process leads to the release of intracellular antigens into the periphery provoking inflammation and development of systemic inflammatory autoimmune disease like systemic lupus erythematosus. Here we review the current findings concerning apoptosis-inducing pathways, important players of apoptotic cell recognition and clearance as well as the role of membrane remodeling in the engulfment of apoptotic cells by phagocytes.
- Physical biology.Phys Biol.2013 Dec 4;10(6):065007. [Epub ahead of print]
- Apoptotic cell death and the clearance of dying cells play an important and physiological role in embryonic development and normal tissue turnover. In contrast to necrosis, apoptosis proceeds in an anti-inflammatory manner. It is orchestrated by the timed release and/or exposure of so-called 'find-m
- PMID 24305041
- Microglia/macrophage polarization dynamics in white matter after traumatic brain injury.
- Wang G, Zhang J, Hu X, Zhang L, Mao L, Jiang X, Liou AK, Leak RK, Gao Y, Chen J.Author information 1] State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Fudan University, Shanghai, China  Department of Neurology, Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA  Department of Neuropharmacology, Institute of Nautical Medicine, Nantong University, Nantong, China.AbstractMononuclear phagocytes are a population of multi-phenotypic cells and have dual roles in brain destruction/reconstruction. The phenotype-specific roles of microglia/macrophages in traumatic brain injury (TBI) are, however, poorly characterized. In the present study, TBI was induced in mice by a controlled cortical impact (CCI) and animals were killed at 1 to 14 days post injury. Real-time polymerase chain reaction (RT-PCR) and immunofluorescence staining for M1 and M2 markers were performed to characterize phenotypic changes of microglia/macrophages in both gray and white matter. We found that the number of M1-like phagocytes increased in cortex, striatum and corpus callosum (CC) during the first week and remained elevated until at least 14 days after TBI. In contrast, M2-like microglia/macrophages peaked at 5 days, but decreased rapidly thereafter. Notably, the severity of white matter injury (WMI), manifested by immunohistochemical staining for neurofilament SMI-32, was strongly correlated with the number of M1-like phagocytes. In vitro experiments using a conditioned medium transfer system confirmed that M1 microglia-conditioned media exacerbated oxygen glucose deprivation-induced oligodendrocyte death. Our results indicate that microglia/macrophages respond dynamically to TBI, experiencing a transient M2 phenotype followed by a shift to the M1 phenotype. The M1 phenotypic shift may propel WMI progression and represents a rational target for TBI treatment.
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.J Cereb Blood Flow Metab.2013 Dec;33(12):1864-74. doi: 10.1038/jcbfm.2013.146. Epub 2013 Aug 14.
- Mononuclear phagocytes are a population of multi-phenotypic cells and have dual roles in brain destruction/reconstruction. The phenotype-specific roles of microglia/macrophages in traumatic brain injury (TBI) are, however, poorly characterized. In the present study, TBI was induced in mice by a cont
- PMID 23942366
- Shuttling Protein Nucleolin is a Microglia Receptor for Amyloid Beta Peptide 1–42
- Ozawa Daisuke,Nakamura Takashi,Koike Masanori,Hirano Kazuya,Miki Yuichi,Beppu Masatoshi
- Biological and Pharmaceutical Bulletin, 2013
- … Mononuclear phagocytes in the brain (microglia), can potentially clear Aβ via phagocytosis. …
- NAID 130003361542
- P2-071 転写因子Fli-1はマウスにおいて単球，マクロファージおよび樹状細胞の分化を制御する
- 鈴木 英二,Gary Gilkeson,Dennis Watson,渡辺 浩志,Zhang Xian
- 日本臨床免疫学会会誌 35(4), 362a-362a, 2012
- … al（CTA）domainを欠いたFli-1（Fli-1ΔCTA）を発現するマウスを作成し，Fli-1ΔCTAが脾のおけるB細胞の分化に影響を与えることえを報告した．免疫系細胞の分化におけるFli-1の更なる役割を知るため，mononuclear phagocytes system（MPS）の分化におけるFli-1の発現の影響を検討した．Fli-1ΔCTA/ΔCTA B6マウスでは野生型マウスと比較して骨髄において造血幹細胞とcommon dendritic cell precursors，脾においてclassical dendritic …
- NAID 130003364106
- The mononuclear phagocyte system (MPS) is a part of the immune system that consists of the phagocytic cells located in reticular connective tissue. The cells are primarily monocytes and macrophages, and they accumulate in lymph nodes ...
- scavenger cell