Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/14 22:54:00」(JST)

wiki en

[Wiki en表示]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 明らかな器質的心疾患のない患者の単形性心室頻脈 monomorphic ventricular tachycardia in the absence of apparent structural heart disease
2. 急性心筋梗塞患者の心室性不整脈の臨床的特徴および治療 clinical features and treatment of ventricular arrhythmias during acute myocardial infarction
3. 心筋梗塞後の患者における心室性不整脈に対する抗不整脈剤の役割 role of antiarrhythmic drugs for ventricular arrhythmias in patients with a prior myocardial infarction
4. 持続性単形性心室頻拍：臨床症状、診断、評価 sustained monomorphic ventricular tachycardia clinical manifestations diagnosis and evaluation
5. 心筋梗塞既往患者における持続性単形性心室頻拍：治療および予後 sustained monomorphic ventricular tachycardia in patients with a prior myocardial infarction treatment and prognosis

English Journal

Metastatic small cell osteosarcoma to the liver: A diagnostic pitfall for fine-needle aspiration cytology.

Ali RH, Lee CH, Hayes MM.Author information Department of Pathology, Vancouver General Hospital, Vancouver, British Columbia, Canada.AbstractWe report the fine-needle aspiration cytology of a case of metastatic small cell osteosarcoma to the liver with rosette formation, originating from distal femur, in a 36-year-old female. The aspirate of the liver metastases revealed a relatively monomorphic population of mitotically active small blue round cells arranged in clusters with prominent rosette formation simulating a neuroendocrine carcinoma or other rosette-forming small round cell tumors such as Ewing sarcoma. No extracellular mineralized matrix material was present. Comparison of the liver aspirate with the biopsy from the distal femoral lesion was crucial in reaching the correct diagnosis of metastatic small cell osteosarcoma with rosette formation. This is a potential diagnostic pitfall, particularly if interpreted without the knowledge of a suspected primary bone tumor. Diagn. Cytopathol. 2014;42:161-164. © 2012 Wiley Periodicals, Inc.
Diagnostic cytopathology.Diagn Cytopathol.2014 Feb;42(2):161-4. doi: 10.1002/dc.22894. Epub 2012 Aug 4.
We report the fine-needle aspiration cytology of a case of metastatic small cell osteosarcoma to the liver with rosette formation, originating from distal femur, in a 36-year-old female. The aspirate of the liver metastases revealed a relatively monomorphic population of mitotically active small blu
PMID 22865770

Basal Cardiomyopathy Develops in Rabbits With Ventricular Tachyarrhythmias Induced by a Single Injection of Adrenaline.

Ashida T, Takato T, Matsuzaki G, Seko Y, Fujii J, Kawai S.Author information Division of Cardiovascular Disease, The Institute for Adult Diseases Asahi Life Foundation.AbstractWe have recently demonstrated that basal cardiomyopathy develops in rabbits with ventricular tachyarrhythmias that have been induced by electrical stimulation of the cervical vagus. This study investigated whether similar basal cardiomyopathy would develop in rabbits with ventricular tachyarrhythmias induced by a single injection of adrenaline. Adrenaline was intravenously infused for 10-360 seconds in anesthetized rabbits. Colloidal carbon was injected after adrenaline infusion. Wall movement velocity of the left ventricular base was assessed by tissue Doppler echocardiography. Animals were killed either 1 week or 3-4 weeks later. Pathological lesions were identified by deposits of carbon particles. Animals were divided into two groups according to the infused dose of adrenaline. The small-dose group (group S, n = 15) received 1-10 μg and the large-dose group (group L, n = 23) received 15-60 μg of adrenaline. Adrenaline infusion induced premature ventricular contractions followed by monomorphic ventricular tachycardias in 22 of 23 animals in group L, but in only 1 of 15 animals in group S. Wall movement velocity of the left ventricular base decreased just after adrenaline infusion, remained low after 1 week, and recovered to near-baseline levels after 3-4 weeks in group L. Unique cardiac lesions identified by deposits of carbon particles were frequently observed on the left ventricular basal portion, almost always associated with the mitral valve and papillary muscles, but were never observed in the apical area. Lesions involving all areas of the left ventricular basal portion were observed in 22 of 23 animals in group L, but in only 2 of 15 animals in group S. Basal cardiomyopathy developed in rabbits with ventricular tachycardias induced by a single injection of adrenaline.
International heart journal.Int Heart J.2014 Jan 27. [Epub ahead of print]
We have recently demonstrated that basal cardiomyopathy develops in rabbits with ventricular tachyarrhythmias that have been induced by electrical stimulation of the cervical vagus. This study investigated whether similar basal cardiomyopathy would develop in rabbits with ventricular tachyarrhythmia
PMID 24463928

High throughput chemical screening for anti-virulence developmental phenotypes in Trypanosoma brucei.

Macgregor P, Ivens A, Shave S, Collie I, Gray D, Auer M, Matthews KR.Author information Centre for Immunity, Infection and Evolution, Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, EH9 3JT.AbstractIn the bloodstream of mammalian hosts, the sleeping sickness parasite, Trypanosoma brucei, exists as a proliferative slender form or a non-proliferative, transmissible, stumpy form. The transition between these developmental forms is controlled by a density-dependent mechanism that is important for the parasite's infection dynamics, immune-evasion via ordered antigenic variation and disease transmissibility. However, stumpy formation has been lost in most laboratory-adapted trypanosome lines generating monomorphic parasites that proliferate uncontrolled as slender forms in vitro and in vivo. Nonetheless, these forms are readily amenable to cell culture and high throughput screening for trypanocidal lead compounds. Here, we have developed and exploited a high throughput screen for developmental phenotypes using a transgenic monomorphic cell line expressing a reporter under the regulation of gene control signals from the stumpy-specific molecule PAD1. Using a whole-cell fluorescence-based assay to screen over 6000 small molecules from a kinase-focused compound library, small molecules able to activate stumpy-specific gene expression and proliferation arrest were assayed in a rapid assay format. Independent follow-up validation identified one hit able to induce modest, yet specific, changes in mRNA expression indicative of a partial differentiation to stumpy forms in monomorphs. Further, in pleomorphs this compound induced a stumpy-like phenotype, entailing growth arrest, morphological changes, PAD1 expression and enhanced differentiation to procyclic forms. This not only provides a potential tool compound for the further understanding of stumpy formation, but also demonstrates the use of high throughput screening in the identification of compounds able to induce specific phenotypes, such as differentiation, in African trypanosomes.
Eukaryotic cell.Eukaryot Cell.2014 Jan 17. [Epub ahead of print]
In the bloodstream of mammalian hosts, the sleeping sickness parasite, Trypanosoma brucei, exists as a proliferative slender form or a non-proliferative, transmissible, stumpy form. The transition between these developmental forms is controlled by a density-dependent mechanism that is important for
PMID 24442893