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increase in the number of monocytes in the blood; symptom of monocytic leukemia

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/15 13:04:34」(JST)

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Monocytosis is an increase in the number of monocytes circulating in the blood.^[1] Monocytes are white blood cells that give rise to macrophages and dendritic cells in the immune system.

In humans, 950/μL is regarded as at the upper limit of normal; monocyte counts above this level are regarded as monocytosis.^{[citation needed]}

Causes

Monocytosis often occurs during chronic inflammation. Diseases that produce this state:

Infections: tuberculosis, brucellosis, listeriosis, subacute bacterial endocarditis, syphilis, and other viral infections and many protozoal and rickettsial infections (e.g. kala azar, malaria, Rocky Mountain spotted fever).
Blood and immune causes: chronic neutropenia and myeloproliferative disorders.
Autoimmune diseases and vasculitis: systemic lupus erythematosus, rheumatoid arthritis and inflammatory bowel disease.
Malignancies: Hodgkin's disease and certain leukaemias, such as chronic myelomonocytic leukaemia (CMML) and monocytic leukemia.
Recovery phase of neutropenia or an acute infection.
Obesity (cf. Nagareddy et al. (2014), Cell Metabolism, Vol. 19, pp 821-835)
Miscellaneous causes: sarcoidosis and lipid storage disease.

References

^ "monocytosis" at Dorland's Medical Dictionary

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1. 好中球増多症の患者へのアプローチ approach to the patient with neutrophilia
2. 慢性骨髄単球性白血病 chronic myelomonocytic leukemia
3. 骨髄異形成症候群の臨床症状および診断 clinical manifestations and diagnosis of the myelodysplastic syndromes
4. 慢性骨髄性白血病の臨床症状および診断 clinical manifestations and diagnosis of chronic myeloid leukemia
5. ワルデンシュトレーム型マクログロブリン血症の疫学、病因、臨床症状、および診断 epidemiology pathogenesis clinical manifestations and diagnosis of waldenstrom macroglobulinemia

English Journal

The Effects of Diet on Occlusive Coronary Artery Atherosclerosis and Myocardial Infarction in Scavenger Receptor Class B, Type 1/Low-Density Lipoprotein Receptor Double Knockout Mice.

Fuller M1, Dadoo O1, Serkis V1, Abutouk D1, MacDonald M1, Dhingani N1, Macri J1, Igdoura SA1, Trigatti BL2.
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mir33 Inhibition Overcomes Deleterious Effects of Diabetes on Atherosclerosis Plaque Regression in Mice.

Distel E1, Barrett T2, Chung KW3, Girgis NM4, Parathath S5, Esau CC6, Murphy AJ7, Moore KJ8, Fisher EA9.
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Rogacev KS1, Zawada AM2, Emrich I2, Seiler S2, Böhm M2, Fliser D2, Woollard KJ2, Heine GH2.
Arteriosclerosis, thrombosis, and vascular biology.Arterioscler Thromb Vasc Biol.2014 Sep;34(9):2120-7. doi: 10.1161/ATVBAHA.114.304172. Epub 2014 Jul 24.
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PMID 25060791

Japanese Journal

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NAID 130003303180

Fcγレセプターと全身性自己免疫疾患

天野浩文
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全身性エリテマトーデス（SLE）をはじめとする全身性の自己免疫疾患では，IgGクラスの自己抗体の産生及び免疫複合体形成に伴う組織障害がその病態形成に重要である．IgG型Fcγレセプター（FcγR）は，IgGのFc部分を認識し，沈着する免疫複合体に対する免疫応答にとって重要な役割を担っている．さらにFcγRは，抗原と複合体を形成したIgGと結合したのち，活性型FcγRと抑制型FcγRであるFcγ …
NAID 10029431513

Therapy-related Myelodysplastic/myeloproliferative Neoplasms with del(5q) and t(1;11)(p32;q23) Lacking MLL Rearrangement

Yamamoto Katsuya,Katayama Yoshio,Shimoyama Manabu,Matsui Toshimitsu
Internal Medicine 49(11), 1031-1035, 2010
… A 69-year-old man was admitted because of macrocytic anemia and peripheral monocytosis: hemoglobin 75 g/L and white blood cells 16.0×109 /L with 22% monocytes. …
NAID 130000251584