monocyte/macrophage inhibitory receptors

同

MIRs MIR, monocyte/macrophage inhibitory receptor monocyte/macrophage immunoglobulin-like receptor

WordNet

1. a substance that retards or stops an activity
2. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
3. restrictive of action; "a repressive regime"; "an overly strict and inhibiting discipline" (同)repressive, repressing
4. a large phagocyte; some are fixed and other circulate in the blood stream
5. a type of granular leukocyte that functions in the ingestion of bacteria

PrepTutorEJDIC

1. 抑制する人(物) / 化学反応抑制剤
2. =sense organ / 受信装置

UpToDate Contents

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• 1. 自然免疫系の概要an overview of the innate immune system [show details]
  … monocytes, macrophages) represent the critical effector component of the innate immune system . Other cell types express pattern recognition receptors (PRRs), including toll-like receptors (TLRs)… activating and inhibitory receptors, including TLRs 2, 3, 4, 5, 7, and 8, and they recognize and respond to the respective TLR ligands directly . Activating receptors are central to…
• 2. 新生児の免疫immunity of the newborn [show details]
  … NK cells express killer inhibitory receptors (KIRs) that recognize certain MHC antigens and… Neonatal monocyte-derived macrophages are substantially less effective at killing group B streptococci and Candida albicans than are adult cells . Neonatal macrophages can initially…
• 3. 癌免疫療法の原則principles of cancer immunotherapy [show details]
  … stimulatory and inhibitory receptors whose expression is regulated by a myriad of cytokines. Together, this configuration is often referred to as the "immune synapse" : The T cell receptor (TCR) complex… Macrophages differentiate into at least two different phenotypes: M1 macrophages, which release interferon (IFN) gamma and are responsible for phagocytosis, and M2 macrophages,… and promotes conversion of T effector cells to Treg cells . Additional cells such as NK cells, monocytes, and dendritic cells also express PD-1 and/or PD-L1. In general, PD-1 and PD-L1/L2 are upregulated …
• 4. 肥満細胞：表面受容体とシグナル伝達mast cells surface receptors and signal transduction [show details]
  … surface receptor expressed on both mast cells and macrophages and appears to regulate basal activation of both cells. Examples of ITIM-independent inhibitory receptors include the mast cell receptor for… recruit macrophages and monocytes . IgE is involved in defense against parasitic infection and in hypersensitivity reactions. It is estimated that there are usually >100,000 Fc-epsilon-RI receptors on the…
• 5. 骨髄造血の制御regulation of myelopoiesis [show details]
  …principally in monocytes/macrophages and B lymphocytes, and also in erythroid cells and granulocytes . Potential target genes include the integrin CD11b, M-CSF receptor, GM-CSF receptor alpha, G-CSF receptor, and …

English Journal

• Finding a Toll on the Route: The Fate of Osteoclast Progenitors After Toll-Like Receptor Activation.

• Souza PPC, Lerner UH.
• Frontiers in immunology. 2019 ;10()1663.
• M-CSF and RANKL are two crucial cytokines stimulating differentiation of mature, bone resorbing, multinucleated osteoclasts from mononucleated progenitor cells in the monocyte/macrophage lineage. In addition to the receptors for M-CSF and RANKL, osteoclast progenitor cells express receptors for seve
• PMID 31379855

• Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer.

• Singhal S, Stadanlick J, Annunziata MJ, Rao AS, Bhojnagarwala PS, O'Brien S, Moon EK, Cantu E, Danet-Desnoyers G, Ra HJ, Litzky L, Akimova T, Beier UH, Hancock WW, Albelda SM, Eruslanov EB.
• Science translational medicine. 2019 02;11(479).
• Data from mouse tumor models suggest that tumor-associated monocyte/macrophage lineage cells (MMLCs) dampen antitumor immune responses. However, given the fundamental differences between mice and humans in tumor evolution, genetic heterogeneity, and immunity, the function of MMLCs might be different
• PMID 30760579

• Thrombopoietin receptor agonists shift the balance of Fcγ receptors toward inhibitory receptor IIb on monocytes in ITP.

• Liu XG, Liu S, Feng Q, Liu XN, Li GS, Sheng Z, Chen P, Liu Y, Wei Y, Dong XY, Qin P, Gao C, Ma C, Zhang L, Hou M, Peng J.
• Blood. 2016 08;128(6)852-61.
• Elevated expression of the activating Fcγ receptor (FcγR) I and FcγRIIa together with decreased expression of the inhibitory FcγRIIb are involved in the pathogenesis of primary immune thrombocytopenia (ITP). Thrombopoietin receptor agonists (TPO-RAs) have been used clinically for the management
• PMID 27281793

Related Links

• Receptors That Inhibit Macrophage Activation: Mechanisms ...

2. Receptors That Inhibit Macrophage-Monocyte Functions 2.1. PD-1 Belongs to the Superfamily of Immunoglobulins, and Its Function Is Associated with Cell Death and Regulating the Activation of Distinct Cell Types PD-1 (CD

• Monocyte - an overview | ScienceDirect Topics

Monocyte Monocytes are defined as blood mononuclear cells with bean-shaped nuclei that express CD11b, CD11c (αX integrin, a subunit of CR4), and CD14 (LPS receptor subunit) in humans, and CD11b plus F4/80 in mice and lack

• Receptors That Inhibit Macrophage Activation: Mechanisms ...

Receptors That Inhibit Macrophage-Monocyte Functions 2.1. PD-1 Belongs to the Superfamily of Immunoglobulins, and Its Function Is Associated with Cell Death and Regulating the Activation of Distinct Cell Types PD-1 (CD-279 ...

Related Pictures

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★リンクテーブル★

リンク元	「MIRs」
関連記事	「inhibitor」「inhibitory」

「MIRs」

　　[★] monocyte/macrophage inhibitory receptors

「inhibitor」

　　[★]

• n.

• 阻害剤、阻害薬、抑制薬、抑制剤、(内在性物質について)インヒビター、抑制物質

関

blocker、depressant、suppressant

　 　

「inhibitory」

　　[★]

• 抑制性の、抑制的な、阻害性の

関

inhibiting、suppressive