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Gut wall replacing type of gastrointestinal stromal tumor presenting as a perforation of the ileal diverticulum.

Ikemura M1, Kunita A1, Miwa Y2, Jimbo K2, Mori K2, Seto Y2, Fukayama M3.
Pathology, research and practice.Pathol Res Pract.2015 Nov;211(11):892-5. doi: 10.1016/j.prp.2015.05.001. Epub 2015 Jun 4.
Gastrointestinal stromal tumors (GISTs) usually form a well-circumscribed mass. Very rarely, however, sporadic GISTs show gut-wall replacing growth, similar to the diffuse hyperplasia of interstitial cells of Cajal (ICC) observed in patients with neurofibromatosis type 1 (NF1) and hereditary GIST. H
PMID 26298631

Assurance of monoclonality in one round of cloning through cell sorting for single cell deposition coupled with high resolution cell imaging.

Evans K1, Albanetti T1, Venkat R1, Schoner R1, Savery J2, Miro-Quesada G2, Rajan B3, Groves C3.
Biotechnology progress.Biotechnol Prog.2015 Sep;31(5):1172-8. doi: 10.1002/btpr.2145. Epub 2015 Sep 18.
Regulatory authorities require that cell lines used in commercial production of recombinant proteins must be derived from a single cell progenitor or clone. The limiting dilution method of cell cloning required multiple rounds of low-density cell plating and microscopic observation of a single cell
PMID 26195345

A patient with elderly-onset atypical hydroa vacciniforme with an indolent clinical course.

Nomura H1, Suzuki H2, Egami S1, Yokoyama T1, Sugiura M1, Tomita K2, Imada M3, Taniguchi K4, Yoshino T4, Iwatsuki K5.
The British journal of dermatology.Br J Dermatol.2015 Sep;173(3):801-5. doi: 10.1111/bjd.13893. Epub 2015 Jul 22.
Hydroa vacciniforme (HV) is a rare photodermatosis that mainly affects children and manifests as vesiculopapular eruptions in sun-exposed areas without systemic symptoms. HV-like lymphoma (HVLL) is one of the Epstein-Barr virus (EBV)-associated lymphoproliferative disorders (LPD) of childhood. Its d
PMID 25965563

PLS-10-3 主膵管型IPMNのmonoclonalityとGNAS遺伝子変異の意義(PLS-10 プレナリーセッション(10)「膵臓」,第114回日本外科学会定期学術集会)

加来裕美子,古賀文二,今福信一,中山樹一郎,古賀佳織,坂田則行,古江増隆
西日本皮膚科 76(3), 210-213, 2014
… しかし，血清中の抗 HTLV-1 抗体が陽性で，右前腕の結節から採取した検体を用いたサザンブロット法で HTLV-1 proviral DNA monoclonality が確認されたことから，再度詳細に血清学的，免疫組織学的に検討し，CD30 陽性を呈した皮膚型の成人Ｔ細胞性白血病・リンパ腫 (ATLL) の皮膚浸潤と診断した。 …
NAID 130004691117

奥村恵子,鈴木悠花,松澤有希,大歳晋平,中田土起丈
皮膚の科学 13(2), 103-107, 2014
14歳，女児。9年前に左下腿に皮疹が出現し，成長に伴い増大した。左下腿屈側に 100×74mm の暗紅色から暗紫紅色の紅斑局面を認めた。病理組織学的には真皮上中層に小型の lymphoid cell の帯状浸潤を呈し，浸潤細胞には核が不整で大型の異型細胞が混在していた。浸潤細胞の大部分はTリンパ球で CD4＋と CD8＋が混在し， PCR 法で単クローン性増殖は認められなかった。Acral p …
NAID 130004679563