WordNet

move something or somebody around; usually over long distances
an exchange of molecules (and their kinetic energy and momentum) across the boundary between adjacent layers of a fluid or across cell membranes
move while supporting, either in a vehicle or in ones hands or on ones body; "You must carry your camping gear"; "carry the suitcases to the car"; "This train is carrying nuclear waste"; "These pipes carry waste water into the river" (同)carry
transport commercially (同)send, ship
street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"
a long truck for carrying motor vehicles (同)car transporter
a crane for moving material with dispatch as in loading and unloading ships
containing one carboxyl group

PrepTutorEJDIC

(ある場所からある場所へ)…‘を'『輸送する』,運搬する《+名+from+名+to+名》 / 《文》《受動態で》(…で)…‘を'夢中にする,有頂天にする《+名+with+名》 / 〈罪人〉‘を'流刑にする / 〈U〉輸送,運送,輸送(交通)機関(transportation) / 〈C〉(軍隊や軍需品を運ぶ)輸送船,輸送機
酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
自動車運搬用大型トラック

UpToDate Contents

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1. 遺伝性運動失調の概要 overview of the hereditary ataxias
2. 片麻痺性片頭痛 hemiplegic migraine
3. 尿酸のバランス uric acid balance

English Journal

Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.

SIGMA Type 2 Diabetes Consortium, Williams AL, Jacobs SB, Moreno-Macías H, Huerta-Chagoya A, Churchhouse C, Márquez-Luna C, García-Ortíz H, Gómez-Vázquez MJ, Burtt NP, Aguilar-Salinas CA, González-Villalpando C, Florez JC, Orozco L, Haiman CA, Tusié-Luna T, Altshuler D.Collaborators (152)Williams AL, Jacobs SB, Moreno-Macías H, Huerta-Chagoya A, Churchhouse C, Márquez-Luna C, García-Ortíz H, Gómez-Vázquez MJ, Burtt NP, Aguilar-Salinas CA, González-Villalpando C, Florez JC, Orozco L, Haiman CA, Tusié-Luna T, Altshuler D, Williams AL, Márquez-Luna C, Huerta-Chagoya A, Ripke S, Gómez-Vázquez MJ, Manning AK, Moreno-Macías H, García-Ortíz H, Neale B, Burtt NP, Aguilar-Salinas CA, Reich D, Stram DO, Fernández-López JC, Romero-Hidalgo S, Altshuler D, Florez JC, Tusié-Luna T, Patterson N, Haiman CA, Aguilar-Delfín I, Martínez-Hernández A, Centeno-Cruz F, Mendoza-Caamal E, Revilla-Monsalve C, Islas-Andrade S, Córdova E, Rodríguez-Arellano E, Soberón X, Orozco L, Florez JC, González-Villalpando C, González-Villalpando ME, Haiman CA, Henderson BE, Monroe K, Wilkens L, Kolonel LN, Le Marchand L, Riba L, Ordóñez-Sánchez ML, Rodríguez-Guillén R, Cruz-Bautista I, Rodríguez-Torres M, Muñoz-Hernández LL, Sáenz T, Gómez D, Alvirde U, Burtt NP, Onofrio RC, Brodeur WM, Gage D, Murphy J, Franklin J, Mahan S, Ardlie K, Crenshaw AT, Winckler W, Prüfer K, Shunkov MV, Sawyer S, Stenzel U, Kelso J, Lek M, Sankararaman S, Williams AL, Patterson N, MacArthur DG, Reich D, Derevianko AP, Pääbo S, Jacobs SB, Churchhouse C, Gopal S, Grammatikos JA, Smith IC, Bullock KH, Deik AA, Souza AL, Pierce KA, Clish CB, Altshuler D, Fennell T, Farjoun Y, Gabriel S, Stram DO, Gross MD, Pereira MA, Seielstad M, Koh WP, Tai ES, Flannick J, Fontanillas P, Morris A, Teslovich TM, Burtt NP, Atzmon G, Blangero J, Bowden DW, Chambers J, Cho YS, Duggirala R, Glaser B, Hanis C, Kooner J, Laakso M, Lee JY, Tai ES, Teo YY, Wilson JG, Haiman CA, Henderson BE, Monroe K, Wilkens L, Kolonel LN, Le Marchand L, Puppala S, Farook VS, Thameem F, Abboud HE, DeFronzo RA, Jenkinson CP, Lehman DM, Curran JE, Blangero J, Duggirala R, Burtt NP, Cortes ML, Altshuler D, Florez JC, Haiman CA, Henderson BE, Aguilar-Salinas CA, González-Villalpando C, Orozco L, Tusié-Luna T.
Nature.Nature.2014 Feb 6;506(7486):97-101. doi: 10.1038/nature12828. Epub 2013 Dec 25.
Performing genetic studies in multiple human populations can identify disease risk alleles that are common in one population but rare in others, with the potential to illuminate pathophysiology, health disparities, and the population genetic origins of disease alleles. Here we analysed 9.2 million s
PMID 24390345

Regulation of monocarboxylic Acid transporter-1 by cAMP dependent vesicular trafficking in brain microvascular endothelial cells.

Uhernik AL, Li L, Lavoy N, Velasquez MJ, Smith JP.Author information Department of Biology, Colorado State University-Pueblo, Pueblo, Colorado, United States of America.AbstractIn this study, a detailed characterization of Monocarboxylic Acid Transporter-1 (Mct1) in cytoplasmic vesicles of cultured rat brain microvascular endothelial cells shows them to be a diverse population of endosomes intrinsic to the regulation of the transporter by a brief 25 to 30 minute exposure to the membrane permeant cAMP analog, 8Br-cAMP. The vesicles are heterogeneous in size, mobility, internal pH, and co-localize with discreet markers of particular types of endosomes including early endosomes, clathrin coated vesicles, caveolar vesicles, trans-golgi, and lysosomes. The vesicular localization of Mct1 was not dependent on its N or C termini, however, the size and pH of Mct1 vesicles was increased by deletion of either terminus demonstrating a role for the termini in vesicular trafficking of Mct1. Using a novel BCECF-AM based assay developed in this study, 8Br-cAMP was shown to decrease the pH of Mct1 vesicles after 25 minutes. This result and method were confirmed in experiments with a ratiometric pH-sensitive EGFP-mCherry dual tagged Mct1 construct. Overall, the results indicate that cAMP signaling reduces the functionality of Mct1 in cerebrovascular endothelial cells by facilitating its entry into a highly dynamic vesicular trafficking pathway that appears to lead to the transporter's trafficking to autophagosomes and lysosomes.
PloS one.PLoS One.2014 Jan 16;9(1):e85957. doi: 10.1371/journal.pone.0085957. eCollection 2014.
In this study, a detailed characterization of Monocarboxylic Acid Transporter-1 (Mct1) in cytoplasmic vesicles of cultured rat brain microvascular endothelial cells shows them to be a diverse population of endosomes intrinsic to the regulation of the transporter by a brief 25 to 30 minute exposure t
PMID 24454947

Downregulation of MCT1 inhibits tumor growth, metastasis and enhances chemotherapeutic efficacy in osteosarcoma through regulation of the NF-κB pathway.

Zhao Z1, Wu MS, Zou C, Tang Q, Lu J, Liu D, Wu Y, Yin J, Xie X, Shen J, Kang T, Wang J.Author information 1Department of Musculoskeletal Oncology, First Afflicted Hospital, Sun Yat-Sen University, Guangzhou 510080, China.AbstractMonocarboxylate transporter isoform 1 (MCT1) is an important member of the proton-linked MCT family and has been reported in an array of human cancer cell lines and primary human tumors. MCT1 expression is associated with developing a new therapeutic approach for cancer. In this study, we initially showed that MCT1 is expressed in a variety of human osteosarcoma cell lines. Moreover, we evaluated the therapeutic response of targeting MCT1 using shRNA or MCT1 inhibitor. Inhibiting MCT1 delayed tumor growth in vitro and in vivo, including in an orthotopic model of osteosarcoma. Targeting MCT1 greatly enhanced the sensitivity of human osteosarcoma cells to the chemotherapeutic drugs adriamycin (ADM). In addition, we observed that MCT1 knockdown significantly suppressed the metastatic activity of osteosarcoma, including wound healing, invasion and migration. Further mechanistic studies revealed that the antitumor effects of targeting MCT1 might be related to the NF-κB pathway. Immunochemistry assay showed that MCT1 was an independent positive prognostic marker in osteosarcoma patients. In conclusion, our data, for the first time, demonstrate that MCT1 inhibition has antitumor potential which is associated with the NF-κB pathway, and high MCT1 expression predicates poor overall survival in patients with osteosarcoma.
Cancer letters.Cancer Lett.2014 Jan 1;342(1):150-8. doi: 10.1016/j.canlet.2013.08.042. Epub 2013 Sep 3.
Monocarboxylate transporter isoform 1 (MCT1) is an important member of the proton-linked MCT family and has been reported in an array of human cancer cell lines and primary human tumors. MCT1 expression is associated with developing a new therapeutic approach for cancer. In this study, we initially
PMID 24012639

Japanese Journal

Non-Involvement of the Human Monocarboxylic Acid Transporter 1 (MCT1) in the Transport of Phenolic Acid

WATANABE Hirohito,YASHIRO Takuya,TOHJO Yuichi,KONISHI Yutaka
Bioscience, biotechnology, and biochemistry 70(8), 1928-1933, 2006-08-23
… Phenolic acids such as p-coumaric acid and microbial metabolites of poorly absorbed polyphenols are absorbed by the monocarboxylic acid transporter (MCT)-mediated transport system which is identical to the fluorescein/H+ cotransport system. … Furthermore, in the MCT1-expressing oocytes, no increase of p-coumaric acid uptake was apparent, whereas the uptake of salicylic acid, a substrate of MCT1, nearly doubled. …
NAID 10018528236

Biochemical and molecular pharmacological aspects of transporters as determinants of drug disposition

SAI Yoshimichi
Drug metabolism and pharmacokinetics 20(2), 91-99, 2005-04-25
… Most of the SLC family transporters consist of 300-800 amino acid residues with a molecular mass of 40-90 kDa, while the corresponding values of ABC family transporters are 1,200-1,500 residues and 140-180 kDa, respectively. … Each transporter has a characteristic tissue distribution and subcellular localization. …
NAID 10015550026