monoamine oxidase inhibitor

出典: meddic

モノアミン酸化酵素阻害薬, MAOI

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/10 20:39:55」(JST)

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  • The evidence-based pharmacotherapy of social anxiety disorder.
  • Blanco C, Bragdon LB, Schneier FR, Liebowitz MR.SourceDepartment of Psychiatry of Columbia College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY, USA.
  • The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP).Int J Neuropsychopharmacol.2013 Feb;16(1):235-49. doi: 10.1017/S1461145712000119. Epub 2012 Mar 21.
  • Social anxiety disorder (SAD) is a highly prevalent and often disabling disorder. This paper reviews the pharmacological treatment of SAD based on published placebo-controlled studies and published meta-analyses. It addresses three specific questions: What is the first-line pharmacological treatment
  • PMID 22436306
  • Selective inhibition of monoamine oxidase A or B reduces striatal oxidative stress in rats with partial depletion of the nigro-striatal dopaminergic pathway.
  • Aluf Y, Vaya J, Khatib S, Loboda Y, Finberg JP.SourceDepartment of Molecular Pharmacology, Rappaport Medical Faculty, Technion, Haifa, Israel; Oxidative Stress Research Laboratory, Migal-Galilee Technology Center, Kiryat Shmona, and Tel Hai College, Israel.
  • Neuropharmacology.Neuropharmacology.2013 Feb;65:48-57. doi: 10.1016/j.neuropharm.2012.08.023. Epub 2012 Sep 7.
  • Partial lesion (50%) of the nigro-striatal dopaminergic pathway induces compensatory increase in dopamine release from the remaining neurons and increased extracellular oxidative stress (OS(-ec)) in the striatum. The present study was designed to explore the role of monoamine oxidase types A and B (
  • PMID 22982254
  • Anxiolytic-like effect of linezolid in experimental mouse models of anxiety.
  • Jindal A, Mahesh R, Kumar B.SourceDepartment of Pharmacy, Birla Institute of Technology & Science, Pilani-333031, Rajasthan, India. Electronic address:
  • Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2013 Jan 10;40:47-53. doi: 10.1016/j.pnpbp.2012.09.006. Epub 2012 Sep 25.
  • Linezolid, an oxazolidinone class antibiotic is a reversible and nonselective inhibitor of monoamine oxidase (MAO) enzyme, mainly for MAO-A subtype. Its antidepressant-like effect has been previously demonstrated in the rodent models of depression. MAO-A enzyme has been shown to play a role in the p
  • PMID 23021974


  • Clorgyline Inhibits Orexin-A-Induced Arousal in Layer-Type Chicks
  • Katayama Sachiko,Shigemi Kazutaka,Cline Mark A. [他],Furuse Mitsuhiro
  • Journal of Veterinary Medical Science 73(4), 471-474, 2011
  • … Because monoamine oxidase-A (MAO-A) is a potent degrading enzyme of these monoamines, we hypothesized that orexin-A may mediate its arousal-inducing effects through MAO-A. … Therefore, we simultaneously injected clorgyline, a specific inhibitor of MAO-A, with orexin-A and examined behavior of chicks. … For the monoamine turnover rate, enhancement of the turnover rate of serotonin by orexin-A was attenuated by clorgyline. …
  • NAID 130000444419
  • Rapid screening of monoamine oxidase B inhibitors in natural extracts by capillary electrophoresis after enzymatic reaction at capillary inlet
  • HU Kun,ZHANG Lichun,LI Xiangtang,ZHAO Shulin
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 878(30), 3156-3160, 2010-11-15
  • NAID 10028043990
  • Combined treatment with MAO-A inhibitor and MAO-B inhibitor increases extracellular noradrenaline levels more than MAO-A inhibitor alone through increases in β-phenylethylamine
  • Kitaichi Yuji,Inoue Takeshi,Nakagawa Shin,Boku Shuken,Izumi Takeshi,Koyama Tsukasa
  • European Journal of Pharmacology 637(1-3), 77-82, 2010-07-10
  • Monoamine oxidase inhibitors (MAO inhibitors) have been widely used as antidepressants. … Using in vivo microdialysis methods, we measured extracellular noradrenaline and serotonin levels following administration of Ro 41-1049, a reversible MAO-A inhibitor and/or lazabemide, a reversible MAO-B inhibitor in the medial prefrontal cortex (mPFC) of rats. …
  • NAID 120002261718




拡張検索monoamine oxidase inhibitors


  [★] モノアミン酸化酵素阻害薬



monoamine oxidase inhibitor, MAOI
MAO阻害薬 MAO inhibitorモノアミンオキシダーゼ阻害薬


  • 起立性低血圧(once the body adapts to higher basal level of catecholamines, it is nolonger able to further vasoconstrict in response to stress), hepatotoxicity, and hypomania.
  • MAO(特にA型)阻害薬使用時に、チラミン含有量の高い食物(ワイン、チーズ、チョコレートなど)を摂取すると、チラミンが分解されずに高血圧発作を起こす

monoamine oxidase inhibitors」





  • v.
  • 抑制する、阻害する、阻止する

WordNet   license wordnet

「limit, block, or decrease the action or function of; "inhibit the action of the enzyme"; "inhibit the rate of a chemical reaction"」

PrepTutorEJDIC   license prepejdic

「〈感情・欲望・行動・作用など〉‘を'抑制する / (…しないように)〈人〉‘を'抑制する,妨げる《+『名』+『from』+『名』(do『ing』)》」

WordNet   license wordnet

「control and refrain from showing; of emotions, desires, impulses, or behavior」
bottle up, suppress

WordNet   license wordnet

「limit the range or extent of; "Contact between the young was inhibited by strict social customs"」



  • n.

WordNet   license wordnet

「a substance that retards or stops an activity」

PrepTutorEJDIC   license prepejdic

「抑制する人(物) / 化学反応抑制剤」


  [★] モノアミン

WordNet   license wordnet

「a molecule containing one amine group (especially one that is a neurotransmitter)」


  [★] オキシダーゼ

WordNet   license wordnet

「any of the enzymes that catalyze biological oxidation」



See Biogenic amines