WordNet

a complex consisting of an organic base in association with hydrogen chloride
antipsychotic drug (trade name Moban) used in the treatment of schizophrenia (同)Moban

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/27 13:14:56」(JST)

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Molindone (Moban) is a therapeutic antipsychotic, used in the treatment of schizophrenia.^[1] It works by blocking the effects of dopamine in the brain, leading to diminished psychoses. It is rapidly absorbed when taken orally.

It is sometimes described as a typical antipsychotic,^[2] and sometimes described as an atypical antipsychotic.^[3]

Molindone was discontinued by its sole supplier, Endo Pharmaceuticals, on January 13, 2010. ^[4]

Adverse effects

The side effect profile of molindone is similar to that of other typical antipsychotics. Unlike most antipsychotics, however, molindone use is associated with weight loss.^[3]^[5]

References

^ "molindone". F.A. Davis Company.
^ Aparasu RR, Jano E, Johnson ML, Chen H (October 2008). "Hospitalization risk associated with typical and atypical antipsychotic use in community-dwelling elderly patients". Am J Geriatr Pharmacother 6 (4): 198–204. doi:10.1016/j.amjopharm.2008.10.003. PMID 19028375.
^ ^a ^b Bagnall A, Fenton M, Kleijnen J, Lewis R (2007). Bagnall, Anne-Marie, ed. "Molindone for schizophrenia and severe mental illness". Cochrane Database Syst Rev (1): CD002083. doi:10.1002/14651858.CD002083.pub2. PMID 17253473.
^ http://www.fda.gov/Drugs/DrugSafety/DrugShortages/ucm050794.htm
^ Allison DB; Mentore JL; Heo M et al. (1999). "Antipsychotic-induced weight gain: a comprehensive research synthesis". Am J Psychiatry 156 (11): 1686–96. PMID 10553730. Free full text

UpToDate Contents

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English Journal

Corrected QT changes during antipsychotic treatment of children and adolescents: a systematic review and meta-analysis of clinical trials.

Jensen KG1, Juul K2, Fink-Jensen A3, Correll CU4, Pagsberg AK5.
Journal of the American Academy of Child and Adolescent Psychiatry.J Am Acad Child Adolesc Psychiatry.2015 Jan;54(1):25-36. doi: 10.1016/j.jaac.2014.10.002. Epub 2014 Oct 16.
OBJECTIVE: To evaluate the effect of antipsychotics on the corrected QT (QTc) interval in youth.METHOD: We searched PubMed (http://www.ncbi.nlm.nih.gov/pubmed) for randomized or open clinical trials of antipsychotics in youth <18 years with QTc data, meta-analyzing the results. Meta-regression a
PMID 25524787

Atypical antipsychotics for psychosis in adolescents.

Kumar A1, Datta SS, Wright SD, Furtado VA, Russell PS.
The Cochrane database of systematic reviews.Cochrane Database Syst Rev.2013 Oct 15;10:CD009582. doi: 10.1002/14651858.CD009582.pub2.
BACKGROUND: Schizophrenia often presents in adolescence, but current treatment guidelines are based largely on studies of adults with psychosis. Over the past decade, the number of studies on treatment of adolescent-onset psychosis has increased. The current systematic review collates and critiques
PMID 24129841

Could repetitive transcranial magnetic stimulation improve neurocognition in early-onset schizophrenia spectrum disorders?

Croarkin PE, Daskalakis ZJ.
Journal of the American Academy of Child and Adolescent Psychiatry.J Am Acad Child Adolesc Psychiatry.2012 Sep;51(9):949-51. doi: 10.1016/j.jaac.2012.05.012.
PMID 22917209

Related Pictures

★リンクテーブル★

リンク元	「モリンドン」「moban」
関連記事	「hydrochloride」

「モリンドン」

Molindone
Systematic (IUPAC) name
	3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-; 1,5,6,7-tetrahydro-4H-indol-4-one
Clinical data
Trade names	Moban
AHFS/Drugs.com	Consumer Drug Information
MedlinePlus	a682238
Pregnancy; category	C;
Legal status	℞ (Prescription only);
Routes of; administration	Oral
Pharmacokinetic data
Metabolism	Hepatic
Half-life	1.5 hours
Excretion	Minor, renal and fecal
Identifiers
CAS Registry Number	7416-34-4
ATC code	N05AE02
PubChem	CID 23897
IUPHAR ligand	207
DrugBank	DB01618
ChemSpider	22342
UNII	RT3Y3QMF8N
KEGG	D08226
ChEMBL	CHEMBL460
Chemical data
Formula	C16H24N2O2
Molecular mass	276.374 g/mol
	SMILES O=C2c1c(c(nc1CCC2CN3CCOCC3)C)CC;
	InChI InChI=1S/C16H24N2O2/c1-3-13-11(2)17-14-5-4-12(16(19)15(13)14)10-18-6-8-20-9-7-18/h12,17H,3-10H2,1-2H3 ; Key:KLPWJLBORRMFGK-UHFFFAOYSA-N ;
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