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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/06 17:24:52」(JST)

Mofezolac (INN) is a non-steroidal anti-inflammatory drug.

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English Journal

Chemopreventive effect of mofezolac on beef tallow diet/azoxymethane-induced colon carcinogenesis in rats.

Miao L, Shiraishi R, Fujise T, Kuroki T, Kakimoto T, Sakata Y, Takashima T, Iwakiri R, Fujimoto K, Shi R, Li X.SourceDepartment of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan.
Hepato-gastroenterology.Hepatogastroenterology.2011 Jan-Feb;58(105):81-8.
BACKGROUND/AIMS: We have previously shown that long-term consumption of 10% beef tallow diet promotes colon carcinogenesis in both saline- and azoxymethane (AOM)-treated rats. Here, we investigated the effects of mofezolac, a selective COX-1 inhibitor, on beef tallow-fed rats with saline- or AOM tre
PMID 21510291

Perrone MG, Scilimati A, Simone L, Vitale P.SourceDepartment of Medicinal Chemistry, University of Bari A. Moro, Via Orabona 4, 70125 (Bari), Italy.
Current medicinal chemistry.Curr Med Chem.2010;17(32):3769-805.
Since cyclooxygenase (COX) isozymes discovery, many papers and reviews have been published to describe the structural bases of COX inhibition, and to debate on the therapeutic and adverse effects of worldwide clinically used nonsteroidal anti-inflammatory drugs (NSAIDs), included COX-2 selective inh
PMID 20858219

Suppression of azoxymethane-induced colon cancer development in rats by a cyclooxygenase-1 selective inhibitor, mofezolac

NIHO Naoko,KITAMURA Tomohiro,TAKAHASHI Mami,MUTOH Michihiro,SATO Hidetaka,MATSUURA Mamoru,SUGIMURA Takashi,WAKABAYASHI Keiji
Cancer science 97(10), 1011-1014, 2006-10-10
NAID 10019377864

Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis

リンク元

Mofezolac
Systematic (IUPAC) name
	[3,4-bis(4-methoxyphenyl)isoxazol-5-yl]acetic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ Prescription only
Routes	Oral
Identifiers
CAS number	78967-07-4
ATC code	None
PubChem	CID 4237
UNII	RVJ0BV3H3Y
KEGG	D01718
Chemical data
Formula	C19H17NO5
Mol. mass	339.34 g/mol
	SMILES COC1=CC=C(C=C1)C2=C(ON=C2C3=CC=C(C=C3)OC)CC(=O)O;
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