modifier gene

出典: meddic

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/02/13 10:30:18」(JST)

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  • SUMO2 overexpression enhances the generation and function of interleukin-17-producing CD8(+) T cells in mice.
  • Won TJ1, Lee YJ1, Hyung KE1, Yang E1, Sohn UD2, Min HY2, Lee do I2, Park SY3, Hwang KW4.
  • Cellular signalling.Cell Signal.2015 Jun;27(6):1246-52. doi: 10.1016/j.cellsig.2015.03.001. Epub 2015 Mar 8.
  • Small ubiquitin-like modifier (SUMO) 2 is a small protein that controls the activity and stability of other proteins by SUMOylation. In this study, T cell-specific SUMO2 overexpressing transgenic mice were generated to study the effect of SUMO2 on T lymphocytes. SUMO2 overexpression promoted differe
  • PMID 25762490
  • Violating the theory of single gene-single disorder: inhibitor development in hemophilia.
  • AlFadhli S1, Nizam R1.
  • Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion.Indian J Hematol Blood Transfus.2015 Jun;31(2):162-8. doi: 10.1007/s12288-014-0473-2. Epub 2014 Nov 20.
  • Hemophilia is clinically and genetically heterogeneous blood disorder with several known gene defects accounting for the diversity of disease phenotype and inhibitor production. Although increasing number of causative mutations have been reported, not much is known regarding the root cause of inhibi
  • PMID 25825553


  • Piebald mutation on a C57BL/6J background
  • , ,
  • Journal of Veterinary Medical Science 77(2), 161-166, 2015
  • … The classic piebald mutation in the endothelin receptor type B (Ednrb) gene was found on rolling Nagoya genetic background (PROD-s/s) mice with white coat spotting. … In expression analyses, rectums of B6.PROD-s/s with megacolon mice showed ~5% of the level of Ednrb gene expression versus B6 mice. …
  • NAID 130004781034
  • Quantitative Trait Loci for Resistance to the Congenital Nephropathy in Tensin 2-Deficient Mice
  • Sasaki Hayato,Sasaki Nobuya,Nishino Tomohiro,Nagasaki Ken-ichi,Kitamura Hiroshi,Torigoe Daisuke,Agui Takashi
  • PLOS ONE 9(6), e99602, 2014-06-26
  • … Previously, we performed a quantitative trait locus (QTL) analysis to identify the causative genes for proteinuria in ICGN mice, and found a deletion mutation of the tensin 2 gene (Tns2(nph), MGI no: 2447990). … Interestingly, the congenic strain carrying the Tns2(nph) mutation on a C57BL/6J (B6) genetic background exhibited milder phenotypes than did ICGN mice, indicating the presence of several modifier genes controlling the disease phenotype. …
  • NAID 120005468142







  • n.
effect modifiermodifying factormodulator

WordNet   license wordnet

「a gene that modifies the effect produced by another gene」
modifier gene

WordNet   license wordnet

「a content word that qualifies the meaning of a noun or verb」

WordNet   license wordnet

「a moderator who makes less extreme or uncompromising」

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  [★] 遺伝子

WordNet   license wordnet

「(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors"」
cistron, factor

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WordNet   license wordnet

「informal term for information; "give me the gen on your new line of computers"」