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Shinde SR, Gangula NR, Kavela S, Pandey V, Maddika S.SourceLaboratory of Cell Death & Cell Survival, Centre for DNA Fingerprinting and Diagnostics (CDFD), Nampally, Hyderabad 500001, India.
Cellular signalling.Cell Signal.2013 Dec;25(12):2511-7. doi: 10.1016/j.cellsig.2013.08.013. Epub 2013 Sep 3.
Mitotic progression is regulated by co-ordinated action of several proteins and is crucial for the maintenance of genomic stability. CHFR (Check point protein with FHA and RING domains) is an E3 ubiquitin ligase and a checkpoint protein that regulates entry into mitosis. But the molecular players in
PMID 24012691

p14(ARF) induces apoptosis via an entirely caspase-3-dependent mitochondrial amplification loop.

Milojkovic A, Hemmati PG, Müer A, Overkamp T, Chumduri C, Jänicke RU, Gillissen B, Daniel PT.SourceClinical and Molecular Oncology, Max Delbrück Centrum für Molekulare Medizin, Berlin-Buch, Germany.
International journal of cancer. Journal international du cancer.Int J Cancer.2013 Dec 1;133(11):2551-62. doi: 10.1002/ijc.28279. Epub 2013 Aug 1.
The p14(ARF) tumor suppressor triggers cell death or cell cycle arrest upon oncogenic stress. In MCF-7 breast carcinoma cells, expression of the tumor suppressor gene p14(ARF) fails to trigger apoptosis but induces an arrest in the G1 and, to a lesser extent, in the G2 phase in the cell division cyc
PMID 23686572

A Computational Model for Overcoming Drug Resistance Using Selective Dual-Inhibitors for Aurora Kinase A and Its T217D Variant.

Barakat KH, Huzil JT, Jordan KE, Evangelinos C, Houghton M, Tuszynski J.SourceLi Ka Shing Applied Virology Institute, Department of Medical Microbiology and Immunology, ‡Department of Oncology, and §Department of Physics, University of Alberta , Edmonton, Alberta P6G 2M7, Canada.
Molecular pharmaceutics.Mol Pharm.2013 Nov 5. [Epub ahead of print]
The human Aurora kinase-A (AK-A) is an essential mitotic regulator that is frequently overexpressed in several cancers. The recent development of several novel AK-A inhibitors has been driven by the well-established association of this target with cancer development and progression. However, resista
PMID 24094068

Recurrent micronucleation through cell cycle progression in the presence of microtubule inhibitors

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Cell Structure and Function advpub(0), 2015
… Although most cell lines undergo mitotic arrest after prolonged exposure to microtubule inhibitors, some cells subsequently exit this state and become tetraploid. … Our observations confirm that nuclear envelope formation occurs when mitotic-arrested cells shift to a pseudo G1 phase and adopt a tetraploid state, accompanied by chromosome decondensation. …
NAID 130004885870

Recurrent Micronucleation through Cell Cycle Progression in the Presence of Microtubule Inhibitors

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Cell Structure and Function 40(1), 51-59, 2015
… Although most cell lines undergo mitotic arrest after prolonged exposure to microtubule inhibitors, some cells subsequently exit this state and become tetraploid. … Our observations confirm that nuclear envelope formation occurs when mitotic-arrested cells shift to a pseudo G1 phase and adopt a tetraploid state, accompanied by chromosome decondensation. …
NAID 130004885868

Melanotic Schwannoma of the Cervical Spine Progressing With Pulmonary Metastasis: Case Report

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Neurologia medico-chirurgica 53(10), 712-716, 2013
… Microscopically, compactly fascicles of spindle-shaped cells with pleomorphic and hypercromatic nuclei, dark brown intracellular pigments, as well as some mitotic figures were seen. … Complete surgical resection remains as the treatment of choice, once the uncommon cases with malignant progression shows low response to chemo and radiotherapy. …
NAID 130003383186