マイナー組織適合抗原
WordNet
- of your secondary field of academic concentration or specialization
- limited in size or scope; "a small business"; "a newspaper with a modest circulation"; "small-scale plans"; "a pocket-size country" (同)modest, small, small-scale, pocket-size, pocket-sized
- not of legal age; "minor children" (同)nonaged, underage
- warranting only temporal punishment; "venial sin" (同)venial
- inferior in number or size or amount; "a minor share of the profits"; "Ursa Minor"
- lesser in scope or effect; "had minor differences"; "a minor disturbance"
- of a scale or mode; "the minor keys"; "in B flat minor"
- of lesser importance or stature or rank; "a minor poet"; "had a minor part in the play"; "a minor official"; "many of these hardy adventurers were minor noblemen"; "minor back roads"
- of lesser seriousness or danger; "suffered only minor injuries"; "some minor flooding"; "a minor tropical disturbance"
- of the younger of two boys with the same family name; "Jones minor"
- any substance (as a toxin or enzyme) that stimulates an immune response in the body (especially the production of antibodies)
- condition in which the cells of one tissue can survive in the presence of cells of another tissue; "a successful graft or transplant requires a high degree of histocompatibility"
PrepTutorEJDIC
- 『小さいほうの,少ない』 / (階級・地位・重要性などが)『劣ったほうの』,重要でない / 重大ではない / 未成年の / (音楽で)短調の / 未成年者 / (大学の科目・課程の)副専攻科目 / (音楽で)短調 / 《the minors》《米》=minor league
- 抗原(生物の体内にはいって免疫体を作る物質)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/17 11:47:54」(JST)
[Wiki en表示]
Minor histocompatibility antigen (a.k.a. MHA) are receptors on the cellular surface of donated organs that are known to give an immunological response in some organ transplants.[1] They cause problems of rejection less frequently than those of the major histocompatibility complex (MHC).
Minor histocompatibility antigens are due to normal proteins that are in themselves polymorphic in a given population. Even when a transplant donor and recipient are identical with respect to their major histocompatibility complex genes, the amino acid differences in minor proteins can cause the grafted tissue to be slowly rejected.
Contents
- 1 Clinical implications
- 2 See also
- 3 References
- 4 External links
Clinical implications
Immunization of mothers against male-specific minor histocompatibility (H-Y) antigens has a pathogenic role in many cases of secondary recurrent miscarriage, that is, recurrent miscarriage in pregnancies succeeding a previous live birth. An example of this effect is that the male:female ratio of children born prior and subsequent to secondary recurrent miscarriage is 1.49 and 0.76 respectively.[2]
See also
References
- ^ Robertson N, Chain J, Millrain M, Scott D, Hashim F, Mankteloner E, Lemonnier F, Simpson E, Dyson J (2007). "Natural regulation of immunity to minor histocompatibility antigens". J Immunol 178 (6): 3558–65. doi:10.4049/jimmunol.178.6.3558. PMID 17339452.
- ^ Nielsen, H. S. (2011). "Secondary recurrent miscarriage and H-Y immunity". Human Reproduction Update. doi:10.1093/humupd/dmr005.
External links
- Minor histocompatibility antigens at the US National Library of Medicine Medical Subject Headings (MeSH)
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Surface antigens
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Major histocompatibility complex/
Human leukocyte antigen |
| MHC class I |
- HLA-A
- HLA-B
- HLA-C
- HLA-E
- HLA-F
- HLA-G
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| MHC class II |
- HLA-DM
- HLA-DO
- HLA-DP
- HLA-DQ
- HLA-DR
- Minor histocompatibility antigen
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| Other |
- Arrestin
- Calgranulin
- Blood group antigens
- Cell adhesion molecules
- Differentiation antigens
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Index of the immune system
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| Description |
- Physiology
- cells
- autoantigens
- autoantibodies
- complement
- surface antigens
- IG receptors
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| Disease |
- Allergies
- Immunodeficiency
- Immunoproliferative immunoglobulin disorders
- Hypersensitivity and autoimmune disorders
- Neoplasms and cancer
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| Treatment |
- Procedures
- Drugs
- antihistamines
- immunostimulants
- immunosuppressants
- monoclonal antibodies
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UpToDate Contents
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- 1. 移植免疫 transplantation immunobiology
- 2. 移植片対宿主病の病因 pathogenesis of graft versus host disease
- 3. 造血細胞移植後の移植片対腫瘍効果の生物学 biology of the graft versus tumor effect following hematopoietic cell transplantation
- 4. 造血細胞移植後の再発の予防および治療のための免疫療法 immunotherapy for the prevention and treatment of relapse following hematopoietic cell transplantation
- 5. 膜性腎症と腎移植 membranous nephropathy and renal transplantation
English Journal
- Novel SNPs of WNK1 and AKR1C3 are associated with preeclampsia.
- Sun CJ1, Li L2, Li X1, Zhang WY1, Liu XW3.
- Gene.Gene.2018 Aug 20;668:27-32. doi: 10.1016/j.gene.2018.05.055. Epub 2018 May 17.
- PMID 29777907
- Incorporating Biologic Factors into the American Joint Committee on Cancer Breast Cancer Staging System: Review of the Supporting Evidence.
- Weiss A1, King TA2, Hunt KK3, Mittendorf EA4.
- The Surgical clinics of North America.Surg Clin North Am.2018 Aug;98(4):687-702. doi: 10.1016/j.suc.2018.03.005. Epub 2018 May 21.
- PMID 30005768
- Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides.
- Wan X1, Zinselmeyer BH1, Zakharov PN1, Vomund AN1, Taniguchi R2, Santambrogio L3, Anderson MS2, Lichti CF1, Unanue ER4.
- Nature.Nature.2018 Jul 18. doi: 10.1038/s41586-018-0341-6. [Epub ahead of print]
- PMID 30022165
Japanese Journal
- 非血縁骨髄移植後の再発に対する臍帯血移植後に, 第1ドナーリンパ球による移植片対白血病効果が認められたTリンパ芽球性リンパ腫
- 非血縁骨髄移植後の再発に対する臍帯血移植後に，第１ドナーリンパ球による移植片対白血病効果が認められたＴリンパ芽球性リンパ腫
- Graft versus leukemia(GVL)効果の標的抗原
Related Links
- A non HLA system which is thought to contribute to this is the minor histocompatibility antigen (mHA) system. Minor histocompatibility antigens comprise of peptides derived from proteins in which some degree of polymorphism ...
- "minor histocompatibility antigen" への豊富な翻訳例文 – 和英辞書と日本語翻訳サーチエンジン ... 本研究において、特に重要な遺伝因子の1つと し て 主 要 組織 適 合 遺伝 子複 合体（MHC：ヒトではヒ ト白 血 球 抗原[ H LA] ） 、お ...
★リンクテーブル★
[★]
- 英
- minor histocompatibility antigen
[★]
- 同
- MHC＆graft rejection
- 関
- graft rejection
[★]
- 関
- a few、minority、small number、trace、trace amount
[★]
- 関
- transplantation antigen
[★]
- 関
- histocompatability、histocompatible