mineralocorticoid

出典: meddic

鉱質コルチコイド

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「hormone that is one of the steroids of the adrenal cortex that influences the metabolism of sodium and potassium」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/29 01:51:06」(JST)

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英文文献

  • Mineralocorticoid receptors and the heart, multiple cell types and multiple mechanisms: a focus on the cardiomyocyte.
  • Bienvenu LA, Reichelt ME, Delbridge LM, Young MJ.Source†Department of Physiology, University of Melbourne, Parkville, VIC 3010, Australia.
  • Clinical science (London, England : 1979).Clin Sci (Lond).2013 Nov 1;125(9):409-21. doi: 10.1042/CS20130050.
  • MR (mineralocorticoid receptor) activation in the heart plays a central role in the development of cardiovascular disease, including heart failure. The MR is present in many cell types within the myocardium, including cardiomyocytes, macrophages and the coronary vasculature. The specific role of th
  • PMID 23829554
  • Aldosterone regulates Na(+), K(+) ATPase activity in human renal proximal tubule cells through mineralocorticoid receptor.
  • Salyer SA, Parks J, Barati MT, Lederer ED, Clark BJ, Klein JD, Khundmiri SJ.SourceDepartment of Medicine, Kidney Disease Program, University of Louisville, Louisville, KY, USA; Department of Physiology, University of Louisville, Louisville, KY, USA.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2013 Oct;1833(10):2143-52. doi: 10.1016/j.bbamcr.2013.05.009. Epub 2013 May 16.
  • The mechanisms by which aldosterone increases Na(+), K(+) ATPase and sodium channel activity in cortical collecting duct and distal nephron have been extensively studied. Recent investigations demonstrate that aldosterone increases Na-H exchanger-3 (NHE-3) activity, bicarbonate transport, and H(+) A
  • PMID 23684706
  • Blockade of corticosteroid receptors induces anxiolytic-like effects in streptozotocin-induced diabetic mice, and synergizes with diazepam.
  • López-Rubalcava C, Paez-Martinez N, Oikawa J.SourceaDepartment of Pharmacobiology, Cinvestav-IPN bPostgraduate and Research Section, School of Medicine, Instituto Politecnico Nacional cDirection for Neuroscience, Instituto Nacional de Psiquiatria Ramon de la Fuente, Mexico City, Mexico.
  • Behavioural pharmacology.Behav Pharmacol.2013 Aug;24(4):320-7. doi: 10.1097/FBP.0b013e3283637de2.
  • Anxiety disorder is a psychiatric condition reported in diabetic patients. It is known that hypothalamus-pituitary-adrenal axis activity is increased in these patients and corticosteroids levels are augmented, whereas the anxiolytic actions of diazepam are reduced. The aim of this study was to evalu
  • PMID 23764904

和文文献

  • Roles of Oxidative Stress and the Mineralocorticoid Receptor in Cardiac Pathology in a Rat Model of Metabolic Syndrome
  • NAGATA KOHZO,MUROHARA TOYOAKI,WATANABE SHOGO,HATTORI TAKUYA,NAGASAWA KAI,MATSUURA NATSUMI,TAKATSU MIWA,MURASE TAMAYO,TAKAHASHI KEIJI
  • Nagoya Journal of Medical Science 77(1-2), 275-289, 2015-02
  • NAID 120005549574
  • Current Challenges in the Management of Heart Failure
  • Circulation Journal 79(5), 948-953, 2015
  • … The management of chronic heart failure (HF) with low ejection fraction (EF) has changed considerably over the past 30 years: the introduction of angiotensin-converting enzyme inhibitors (ACEIs), β-blockers, angiotensin-receptor blockers, mineralocorticoid-receptor antagonists and recently, the Ifblocker, ivabradine, has led to a significant reduction in overall mortality and HF mortality. …
  • NAID 130005066279
  • Glucocorticoids Induce Cardiac Fibrosis via Mineralocorticoid Receptor in Oxidative Stress: Contribution of Elongation Factor Eleven-Nineteen Lysine-Rich Leukemia (ELL)
  • Omori Yosuke,Mano Toshiaki,Ohtani Tomohito,Sakata Yasushi,Takeda Yasuharu,Tamaki Shunsuke,Tsukamoto Yasumasa,Miwa Takeshi,Yamamoto Kazuhiro,Komuro Issei
  • Yonago Acta medica 57(3), 109-116, 2014-09
  • NAID 120005482531

関連リンク

Biochemistry. any of a group of corticosteroid hormones, synthesized by the adrenal cortex, that regulate the excretion or reabsorption of sodium and potassium ... mineralocorticoid min·er·al·o·cor·ti·coid (mĭn'ər-ə-lō-kôr'tĭ-koid') n. ...
There is increasing evidence demonstrating that the renoprotective effects of mineralocorticoid receptor (MR) blockade are independent of the effects exerted by renin-angiotensin inhibitors. MR is expressed not only in tubular cells but ...

関連画像

Mineralocorticoid Receptor Antagonists condition related to mineralocorticoid Unfortunately we are unable to provide Receptors, Mineralocorticoid  of Apparent Mineralocorticoid Excess (AME, Mineralocorticoid (Mineralocorticoid


★リンクテーブル★
リンク元鉱質コルチコイド」「mineral corticoid
拡張検索mineralocorticoid-responsive hyponatremia of the elderly

鉱質コルチコイド」

  [★]

mineral corticoid MC, mineralocorticoid
ミネラルコルチコイド電解質コルチコイド
ホルモンコルチコイド副腎皮質ホルモン糖質コルチコイドアルドステロン
[show details]


概念

  • 副腎皮質で産生・分泌され、電解質代謝に関与する。

種類

分類

性状

  • ステロイド

産生組織

  • 副腎皮質球状層の細胞(主に)

標的組織

作用

  • 腎集合管、唾液腺、乳腺、汗腺などに働いてNa+の再吸収を促進し、K+の排出(分泌)を促進する
  • 腎集合管でH+の排出(分泌)を促進する  →  血中HCO3-濃度上昇

分泌の調整

  • アンジオテンシンIIが副腎皮質球状層細胞に作用してアルドステロンの分泌合成を促す (SP.899)
  • レニン-アンジオテンシン-アルドステロン系の最後のホルモン



mineral corticoid」

  [★] 電解質コルチコイドミネラルコルチコイド鉱質コルチコイドmineralocorticoid


mineralocorticoid-responsive hyponatremia of the elderly」

  [★] 鉱質コルチコイド反応性低ナトリウム血症 MRHE




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