milk hypersensitivity

WordNet

1. exploit as much as possible; "I am milking this for all its worth"
2. add milk to; "milk the tea"
3. take milk from female mammals; "Cows need to be milked every morning"
4. a white nutritious liquid secreted by mammals and used as food by human beings
5. any of several nutritive milklike liquids
6. produced by mammary glands of female mammals for feeding their young
7. a Cypriot monetary unit equal to one thousandth of a pound
8. a unit of length equal to one thousandth of an inch; used to specify thickness (e.g., of sheets or wire)
9. an angular unit used in artillery; equal to 1/6400 of a complete revolution
10. the syllable naming the third (mediant) note of any major scale in solmization
11. pathological sensitivity
12. extreme sensitivity
13. a river that rises in the Rockies in northwestern Montana and flows eastward to become a tributary of the Missouri River (同)Milk River

PrepTutorEJDIC

1. (雌の哺乳(ほにゅう)動物が分泌する)乳,(特に食料としての)『牛乳』,『ミルク』 / (植物の)乳汁,乳剤,乳液 / 〈牛など〉‘の'乳をしぼる / 〈情報など〉‘を'引き出す;(…を)〈人〉‘から'しぼり取る《+『名』+『of』+『名』》 / (毒を)〈蛇〉‘から'抜き取る《+『名』+『of』+『名』》 / 〈牛などが〉乳を出す
2. ミル(1000分の1インチ)
3. ミ(全音階の第3音)
4. 過敏,過敏症

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/01 20:46:09」(JST)

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Not to be confused with Lactose intolerance.

Milk allergy
A glass of pasteurized cow milk
Classification and external resources
ICD-9-CM	995.3, V15.02

A milk allergy is a food allergy, an adverse immune reaction to one or more of the constituents of milk from any animal (most commonly alpha S1-casein, a protein in cow's milk). This milk-induced allergic reaction can involve anaphylaxis, a potentially life-threatening condition.

Allergy

A person with milk allergy can be reactive to one of dozens of the proteins within milk. The most common one is alpha S1-casein.

Alpha S1-caseins do differ between species; but almost all commercially farmed animals produce antigenically similar milk. This explains why someone with an allergic reaction to cow's milk cannot drink sheep's or goat's milk, but can drink breast milk without an allergic reaction.

The allergy may be caused by the presence of specific milk antibodies or specific milk-sensitive lymphocytes. This gives rise to the two distinct forms of milk allergy: Antibody-mediated allergy, and Non-antibody mediated allergy.

Antibody-mediated allergy

The effects of antibody-mediated allergy are rapid in onset, evolving within minutes or seconds. These allergies always arise within an hour of drinking milk; but can occasionally be delayed longer when eating food containing milk as an ingredient.

The principal symptoms are gastrointestinal, dermatological, and respiratory. These can translate to: skin rash, hives, vomiting, and gastric distress such as diarrhea, rhinitis, stomach pain, wheeze, or full-blown anaphylactic reactions.

Difference between milk allergy and lactose intolerance

Milk allergy is a food allergy, an adverse immune reaction to a food protein that is normally harmless to the nonallergic individual. Lactose intolerance is a nonallergic food sensitivity, and comes from a lack of production of the enzyme lactase, required to digest the predominant sugar in milk. Adverse effects of lactose intolerance generally occur after much higher levels of milk consumption than do adverse effects of milk allergy.

Lactose intolerance is considered the normal state for most adults on a worldwide scale and is not typically considered to be a disease condition.

Non-antibody mediated allergy

Cows' milk protein allergy (CMPA) is delayed reaction to the milk protein that is normally harmless to the nonallergic, tolerant individual. CMPA is mediated by T-lymphocytes, and is not detectable by allergy blood tests. Because it is not caused by antibodies, it can take several hours, or even up to 72 hours to produce a clinical effect. This makes it harder to diagnose, but also means that it cannot give rise to anaphylaxis, as there are no antibodies to trigger mast cells.

CMPA produces a range of symptoms: The principal symptoms are gastrointestinal, and dermatological. These can translate to: atopic dermatitis, vomiting, and gastric distress such as infantile colic, ]], gastroesophageal reflux, oesophagitis, diarrhea (typically in the very young), constipation (typically in older children), stomach pain, or flatulence. In some cases, particularly infants, it may also include blood and/or mucus in the stool.

Treatment for CMPA is very similar to that for antibody-mediated milk allergy. Some people may also have be allergic to soy protein(s), a combination called a milk soy protein intolerance.

Treatment

The main treatment for milk allergy is total avoidance of milk proteins. Products in addition to milk itself to be avoided by those with milk allergy include yogurt, butter, cheese, and cream. Goats' milk products and sheep's milk almost invariably also need to be avoided. In extremely rare cases, rare or uncooked beef may also cause a mild reaction.

Ingredients that also denote that food product contains dairy milk include whey, casein, caseinate, butter flavor, lactic acid (derived from dairy products), natural or artificial flavors such as milk or butter flavor, and sodium caseinate.

Milk or milk derivatives commonly are included in processed foods such as bread, crackers, cookies, cakes, prepared meats, "soy cheese", soups, gravies, crisps, margarine, and products labeled "nondairy", such as whipped topping and creamer (nondairy simply means less than 0.5% milk by weight).

In some cases, heating the dairy product can denature the proteins, (e.g. baking bread, or other baked goods). Only the ingredients that are chemically reacting will denature. Consequently, some allergic people are able to tolerate cooked foods that contain some milk.

Many processed foods that do not contain milk may be processed on equipment contaminated with dairy foods, which may cause an allergic reaction in some sensitive individuals.

Milk avoidance and replacement for infants

Since milk proteins may be transferred from a breastfeeding mother to an allergic infant, lactating mothers of allergic infants can simply be put on a dairy elimination diet. For formula-fed infants, milk substitute formulas are used to provide a complete source of nutrition. Milk substitutes include soy-based formulas, hypoallergenic formulas based on partially or extensively hydrolyzed protein, and free amino acid-based formulas.

Nondairy-derived, amino acid-based formulas, known as amino acid formulas or elemental formulas, are considered the gold standard in the treatment of cows'-milk allergy when the mother is unable to breastfeed.

Hydrolyzed formulas are available in partially hydrolyzed and extensively hydrolyzed varieties. Partially hydrolyzed formulas are characterized by a larger proportion of long-chain peptides and are considered more palatable. However, they are intended for milder cases and are not considered suitable for treatment of moderate to severe milk allergy or intolerance. Extensively hydrolyzed formulas are composed of proteins that have been largely broken down into free amino acids and short peptides. Casein and whey are the most commonly used sources of protein in hydrolyzed formulas because of their high nutritional quality and their amino acid composition.

Soy-based formula poses a risk of allergic sensitivity, as some infants who are allergic to milk may also be allergic to soy.

Milk substitution for children and adults

Many commercially available replacements for milk for children and adults exist. Rice milk, soy milk, oat milk, coconut milk, almond milk, or milk based on carob seeds are sometimes used as milk substitutes.

On an avoidance diet, reducing the longer-term risk of calcium deficiency and osteoporosis is possible by incorporating other sources of calcium, although the effect of calcium and vitamin D supplementation on osteoporosis is not always clear. Fruit juices supplemented with calcium, sesame seeds, hemp seeds and some kinds of tofu are other calcium sources.

Accidental exposure

Treatment for accidental ingestion of milk products by allergic individuals varies depending on the sensitivity of the person. Frequently medications such as an epinephrine pen or an antihistamine such as diphenhydramine (Benadryl) are prescribed by an allergist in case of accidental ingestion. Sometimes prednisone will be prescribed to prevent a possible late phase Type I hypersensitivity reaction. Milk allergy can cause anaphylaxis, a severe, life-threatening allergic reaction.

Desensitization

Desensitization, which is a slow process of eating tiny amounts of milk, until the body is able to tolerate more significant exposure, results in reduced symptoms or even remission of the allergy in some people. Sometimes this is done by putting a tiny amount of milk under the tongue, sublingual immunotherapy. The other main approach for milk allergy involves eating a small amount of milk, perhaps baked into food. This is called oral immunotherapy. Sublingual immunotherapy may be somewhat safer, but less effective. However, this may not be permanent and is still being researched.

Epidemiology

Milk allergy is the most common food allergy in early childhood. It affects between 2% and 3% of infants in developed countries, but 85–90% of affected children lose clinical reactivity to milk once they pass three years of age. The prevalence of milk allergy in adults is between 0.1% and 0.5%.

Between 13% and 20% of children allergic to milk are also allergic to beef.

Rate of hospitalization

Milk allergy is found to be associated with increased hospitalization rates and steroid use among children with asthma.

Prognosis

Identification of the offending agents early is advised, especially in patients with high risk, and they must avoid them for a better long-term prognosis.

See also

• Allergy
• Anaphylaxis
• Dairy product
• Human-milk bank
• Lactose intolerance
• List of allergies
• Milk soy protein intolerance
• Medical emergencies

References

External links

• A muffin a day could keep milk allergy at bay
• Eating without Casein Practical guide to milk-free eating
• Milk Allergy at Food Allergy Initiative

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. ミルクアレルギー：臨床的特徴および診断 milk allergy clinical features and diagnosis
• 2. 乳アレルギー：管理 milk allergy management
• 3. 早産児のための搾乳 breast milk expression for the preterm infant
• 4. 食物アレルゲン：臨床的特徴および交叉反応の概要 food allergens overview of clinical features and cross reactivity
• 5. 早産児のための授乳および強化母乳栄養 human milk feeding and fortification of human milk for premature infants

English Journal

• Food protein-induced enterocolitis syndrome: an update on natural history and review of management.

• Leonard SA, Nowak-W?grzyn A.SourceJaffe Food Allergy Institute, Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, New York.
• Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.Ann Allergy Asthma Immunol.2011 Aug;107(2):95-101.
• OBJECTIVES: To review the clinical features, pathophysiology, and management of food protein-induced enterocolitis syndrome (FPIES) and to discuss new observations in epidemiology and natural history.DATA SOURCES: PubMed searches were performed for articles published between 1978 and May 2011 using
• PMID 21802016

Japanese Journal

• Preparation and Immunological Characterization of β-Lactoglobulin-Amylose Conjugate

• NODAKE Yuichi,FUKUMOTO Shoichi,FUKASAWA Masashi,YAMASAKI Nobuyuki,SAKAKIBARA Ryuzo
• Bioscience, Biotechnology, and Biochemistry 75(1), 165-167, 2011
• … β-Lactoglobulin (BLG), a major allergen of cow’s milk, was conjugated with the N-hydroxysuccinimide ester of the amylose-glycylglycine adduct (AG-ONSu) to reduce its immunogenicity, and the biochemical and immunological properties of the resulting conjugate (AG-BLG) were studied. … These findings suggest that AG-ONSu can be used advantageously to suppress the hypersensitivity mediated by IgG antibodies in milk allergy. …
• NAID 130000406554

Related Links

• Milk allergy - Wikipedia, the free encyclopedia

A Milk allergy is a food allergy, an adverse immune reaction to one or more of the constituents of milk from any animal (most commonly alpha S1-casein, a protein in cow's milk). This milk induced allergic reaction can involve ...

Related Pictures

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★リンクテーブル★

リンク元	「牛乳アレルギー」「ミルク過敏症」「ミルクアレルギー」「milk allergy」
関連記事	「mi」「hypersensitivity」「milk」

「牛乳アレルギー」

　　[★]

英

milk allergy、milk hypersensitivity

同

牛乳蛋白過敏症、ミルクアレルギー

関

乳アレルギー、ミルク過敏症

「ミルク過敏症」

　　[★]

英

milk hypersensitivity

関

牛乳アレルギー、ミルクアレルギー

「ミルクアレルギー」

　　[★]

英

milk hypersensitivity

関

牛乳アレルギー、ミルク過敏症

「milk allergy」

　　[★]

牛乳アレルギー、乳アレルギー

関

milk hypersensitivity

「mi」

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mi-, mio-

• conb form

• より小さい、より少ない。劣った

• ex.

• miosis 縮瞳

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MI

　 　

「hypersensitivity」

　　[★] アレルギー 　 　 　

「milk」

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