UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

English Journal

Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells.

de Vrij J1, Maas SL1, Kwappenberg KM2, Schnoor R1, Kleijn A3, Dekker L4, Luider TM4, de Witte LD5,6, Litjens M5, van Strien ME5, Hol EM5,7,8, Kroonen J1, Robe PA1, Lamfers ML3, Schilham MW2, Broekman ML1.
International journal of cancer. Journal international du cancer.Int J Cancer.2015 Oct 1;137(7):1630-42. doi: 10.1002/ijc.29521. Epub 2015 Apr 7.
Glioblastoma multiforme (GBM) is the most common primary brain tumor and is without exception lethal. GBMs modify the immune system, which contributes to the aggressive nature of the disease. Particularly, cells of the monocytic lineage, including monocytes, macrophages and microglia, are affected.
PMID 25802036

Differentiating sepsis from non-infectious systemic inflammation based on microvesicle-bacteria aggregation.

Herrmann IK1, Bertazzo S, O'Callaghan DJ, Schlegel AA, Kallepitis C, Antcliffe DB, Gordon AC, Stevens MM.
Nanoscale.Nanoscale.2015 Aug 28;7(32):13511-20. doi: 10.1039/c5nr01851j. Epub 2015 Jul 23.
Sepsis is a severe medical condition and a leading cause of hospital mortality. Prompt diagnosis and early treatment has a significant, positive impact on patient outcome. However, sepsis is not always easy to diagnose, especially in critically ill patients. Here, we present a conceptionally new app
PMID 26201870

Vajen T, Mause SF, Koenen RR1.
Thrombosis and haemostasis.Thromb Haemost.2015 Jul 28;114(2):228-36. doi: 10.1160/TH14-11-0962. Epub 2015 May 21.
Microvesicles are receiving increased attention not only as biomarkers but also as mediators of cell communication and as integral effectors of disease. Platelets present a major source of microvesicles and release these microvesicles either spontaneously or upon activation. Platelet-derived microve
PMID 25994053