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1. 未分化リンパ腫キナーゼ（ALK）融合癌遺伝子陽性非小細胞肺癌 anaplastic lymphoma kinase alk fusion oncogene positive non small cell lung cancer
2. 前頭側頭型認知症：疫学、病理学、および病因 frontotemporal dementia epidemiology pathology and pathogenesis
3. フォンヒッペル・リンダウ病の分子生物学および病因 molecular biology and pathogenesis of von hippel lindau disease
4. 進行性核上性麻痺（PSP） progressive supranuclear palsy psp
5. パーキンソン病の病因および発症機序 etiology and pathogenesis of parkinson disease

New imidazoquinoxaline derivatives: Synthesis, biological evaluation on melanoma, effect on tubulin polymerization and structure-activity relationships.

Zghaib Z1, Guichou JF2, Vappiani J3, Bec N4, Hadj-Kaddour K3, Vincent LA3, Paniagua-Gayraud S3, Larroque C4, Moarbess G5, Cuq P3, Kassab I5, Deleuze-Masquéfa C6, Diab-Assaf M5, Bonnet PA3.
Bioorganic & medicinal chemistry.Bioorg Med Chem.2016 Jun 1;24(11):2433-40. doi: 10.1016/j.bmc.2016.04.004. Epub 2016 Apr 1.
Microtubules are considered as important targets of anticancer therapy. EAPB0503 and its structural imidazo[1,2-a]quinoxaline derivatives are major microtubule-interfering agents with potent anticancer activity. In this study, the synthesis of several new derivatives of EAPB0503 is described, and th
PMID 27094151

Ritter A1, Kreis NN1, Louwen F1, Wordeman L2, Yuan J1.
Critical reviews in biochemistry and molecular biology.Crit Rev Biochem Mol Biol.2016 May 5:1-18. [Epub ahead of print]
Chromosome stability is ensured by precisely fine-tuned dynamics of mitotic spindles, which are controlled by a network of various microtubule-associated and interacting proteins including the kinesin-13 family. The best characterized member of this family is the mitotic centromere-associated kinesi
PMID 27146484

Indole based tubulin polymerization inhibitors: An update on recent developments.

Sunil D1, Kamath PR.
Mini reviews in medicinal chemistry.Mini Rev Med Chem.2016 May 5. [Epub ahead of print]
The exploration of cancer microenvironment and its physiology have exposed a number of potential molecular targets for selective therapeutic intervention by anti-cancer agents. Microtubules are basic cell components formed by polymerization of αβ heterodimers which play a pivotal role in cellular
PMID 27145853

New 2-Aryl-1,4-naphthoquinone-1-oxime Methyl Ether Compound Induces Microtubule Depolymerization and Subsequent Apoptosis

Sato Hiromi,Yamada Ryota,Yanagihara Midori [他],OKUZAWA Hiroko,IWATA Hiroki,KUROSAWA Ayako,ICHINOMIYA Saki,SUZUKI Rina,OKABE Hiroyuki,YANO Tomohiro,KUMAMOTO Takuya,SUZUKI Noriyuki,ISHIKAWA Tsutomu,UENO Koichi
Journal of pharmacological sciences 118(4), 467-478, 2012-04-20
… Moreover, it could cause microtubule depolymerization both in vitro and in vivo. … In conclusion, QO-1 has promising antitumor effects via microtubule depolymerization. …
NAID 10030572009

Relationship between the Structures of Taxane Derivatives and Their Microtubule Polymerization Activity

HIDAKA Masafumi,KOGA Tomoe,KIYOTA Hiromasa [他],HORIGUCHI Tohru,SHI Qing-Wen,HIROSE Keiko,UCHIDA Takafumi
Bioscience, biotechnology, and biochemistry 76(2), 349-352, 2012-02-23
… Paclitaxel (Taxol), one of the most potent anticancer drugs, is a microtubule-stabilizing compound that inhibits microtubule depolymerization within the cell. …
NAID 10030400057

Cytoskeletal and Ultrastructural Studies on Regenerating Cells from the Protoplasts of Valonia (Siphonocladales, Chlorophyceae)

Elvira Paul Rommel,Okuda Kazuo
黒潮圏科学 5(1), 39-49, 2011-03-00
… A new cell wall was produced within 24 hours simultaneous with CMT andAF depolymerization. …
NAID 40019151989