microsomal ethanol oxidizing system

同

MEOS

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MEOS

WordNet

1. (physical chemistry) a sample of matter in which substances in different phases are in equilibrium; "in a static system oil cannot be replaced by water on a surface"; "a system generating hydrogen peroxide"
2. instrumentality that combines interrelated interacting artifacts designed to work as a coherent entity; "he bought a new stereo system"; "the system consists of a motor and a small computer"
3. a group of independent but interrelated elements comprising a unified whole; "a vast system of production and distribution and consumption keep the country going" (同)scheme
4. a complex of methods or rules governing behavior; "they have to operate under a system they oppose"; "that language has a complex system for indicating gender" (同)system of rules
5. a group of physiologically or anatomically related organs or parts; "the body has a system of organs for digestion"
6. a procedure or process for obtaining an objective; "they had to devise a system that did not depend on cooperation"
7. the living body considered as made up of interdependent components forming a unified whole; "exercise helped him get the alcohol out of his system"
8. of or relating to microsomes

PrepTutorEJDIC

1. 〈C〉(関連した部分から成る)『体系』,系統,組織[網],装置 / 〈C〉(教育・政治などの)『制度』,機構;《the~》体制 / 〈C〉(思想・学問などの)『体系』,学説 / 〈C〉(…の)『方法』,方式,やり方《+of doing》 / 〈U〉正しい方針(筋道,順序) / 〈U〉《the~》(身体の)組織,系統 / 〈U〉《the~,one's~》身体,全身
2. =alcohol

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/25 05:03:07」(JST)

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For other uses, see Meos (disambiguation).

The microsomal ethanol oxidizing system (MEOS) is an alternate pathway of ethanol metabolism that occurs in the microsome in the oxidation of ethanol to acetaldehyde. While playing only a minor role in ethanol metabolism in average individuals, MEOS activity increases after chronic alcohol consumption. The MEOS pathway requires the CYP2E1 enzyme, part of the cytochrome P450 family of enzymes, to convert ethanol to acetaldehyde. Ethanol’s affinity for CYP2E1 is lower than its affinity for alcohol dehydrogenase. It has delayed activity in non-chronic alcohol consumption states as increase in MEOS activity is correlated with an increase in production of CYP2E1, seen most conclusively in alcohol dehydrogenase negative deer mice.

The MEOS pathway converts ethanol to acetaldehyde by way of a redox reaction. In this reaction, ethanol is oxidized (losing two hydrogens) and O₂ is reduced (by accepting hydrogen) to form H₂O. NADPH is used as donor of hydrogen, forming NADP⁺. This process consumes ATP and dissipates heat, thus leading to the hypothesis that long term drinkers see an increase in resting energy expenditure.

References

UpToDate Contents

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• 1. 小児におけるエタノール中毒：疫学、毒性の推定、および毒性作用 ethanol intoxication in children epidemiology estimation of toxicity and toxic effects
• 2. 成人におけるエタノール 中毒 ethanol intoxication in adults
• 3. 小児におけるエタノール中毒：臨床的特徴、評価、およびマネージメント ethanol intoxication in children clinical features evaluation and management
• 4. 二次性中枢神経系リンパ腫の臨床症状および診断 clinical presentation and diagnosis of secondary central nervous system lymphoma
• 5. 中枢神経系病変を有するHIV感染患者に対するアプローチ approach to hiv infected patients with central nervous system lesions

English Journal

• Severe Methanol Poisoning with Supralethal Serum Formate Concentration: A Case Report.

• Nurieva O1, Kotikova K.
• Medical principles and practice : international journal of the Kuwait University, Health Science Centre.Med Princ Pract.2015 Oct;24(6):581-3. doi: 10.1159/000439350. Epub 2015 Sep 18.
• OBJECTIVE: To present a case of survival without visual and central nervous system sequelae at a formate concentration of twice the reported lethal level.CLINICAL PRESENTATION AND INTERVENTION: This was a case of a 33-year-old man who ingested 1 liter of a toxic mixture of methanol and ethanol. Upon
• PMID 26380973

• Oral or intraperitoneal binge drinking and oxidative balance in adolescent rats.

• Nogales F1, Rua RM, Ojeda ML, Murillo ML, Carreras O.
• Chemical research in toxicology.Chem Res Toxicol.2014 Nov 17;27(11):1926-33. doi: 10.1021/tx5002628. Epub 2014 Nov 5.
• Oxidative imbalance is one of the most important mechanisms of alcohol-induced injury. Acute alcohol exposure induces a significant amount of reactive oxygen species during its hepatic metabolism via the microsomal ethanol oxidizing system. During adolescence, the physiological development is still
• PMID 25330177

• [Molecular evidences of non-ADH pathway in alcohol metabolism and Class III alcohol dehydrogenase (ADH3)].

• Haseba T.
• Nihon Arukōru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence.Nihon Arukoru Yakubutsu Igakkai Zasshi.2014 Jun;49(3):159-68.
• Class I alcohol dehydrogenase (ADH1), a key enzyme of alcohol metabolism, contributes around 70% to the systemic alcohol metabolism and also to the acceleration of the metabolism due to chronic alcohol consumption by increasing its liver content, if the liver damage or disease is not apparent. Howev
• PMID 25223084

Japanese Journal

• DI BOX 相互作用ノート 慢性飲酒によるCYP誘導で薬剤の効果減弱 : テオフィリンやアセトアミノフェン服用中の飲酒は「適量」厳守を

• 日経ドラッグインフォメーションpremium (170), 58-60, 2011-12
• … 　体内に吸収されたアルコール（エタノール）は、大部分が肝臓におけるアルコール脱水素酵素（ADH）／アルデヒド脱水素酵素（ALDH）系で代謝されるが、約1割はミクロソーム・エタノール酸化系（microsomal　ethanol-oxidizing　system：MEOS）で代謝される。 …
• NAID 40019127260

• Caffeic acid inhibits the formation of 1-hydroxyethyl radical in the reaction mixture of rat liver microsomes with ethanol partly through its metal chelating activity

• Ikeda Hideyuki,Kimura Yuka,Masaki Miho,Iwahashi Hideo
• Journal of Clinical Biochemistry and Nutrition 48(3), 187-193, 2011
• … Effect of caffeic acid on the formation of 1-hydroxyethyl radicals via the microsomal ethanol-oxidizing system pathway was examined. …
• NAID 130004879245

• ラット肝のエタノール代謝,及び薬物代謝の酵素活性に及ぼすエタノールと経口ステロイドホルモン剤の影響

• 堀口 美恵子,幸山 義人,岩間 昌彦 [他],菅家 祐輔
• 大妻女子大学家政系研究紀要 45, 107-115, 2009-03-03
• NAID 110007515845

Related Links

• Microsomal ethanol-oxidizing system. - National Center for ...

1. Enzyme. 1987;37(1-2):45-56. Microsomal ethanol-oxidizing system. Lieber CS. Advances in our knowledge of the microsomal metabolism of ethanol enable us to understand a number of complications that develop in the alcoholic.

• microsomal ethanol-oxidizing system - definition of ...

mi·cro·so·mal eth·a·nol-ox·i·diz·ing sys·tem (MEOS) (mī'krō-sō'măl eth'ă-nol-oks'i-dīz-ing sis'tĕm) A hepatic enzyme system that metabolizes ... Microsomal ethanol-oxidizing system (MEOS): An enzyme system that breaks down ...

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関連記事	「system」「microsomal」

「system」

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• n.

• 系、システム、体系、体制、方式

関

method、series、strain

　 　 　 　 　 　 　 　

「microsomal」

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• adj.

• ミクロソームの

関

microsome