WordNet
- convert into a sulfate
- a salt or ester of sulphuric acid (同)sulphate
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- 1. 硫酸マグネシウムへの子宮内曝露の神経保護効果 neuroprotective effects of in utero exposure to magnesium sulfate
- 2. 成人におけるS状結腸鏡検査および大腸内視鏡検査のための前処置 bowel preparation for colonoscopy and flexible sigmoidoscopy in adults
- 3. デヒドロエピアンドロステロンおよびその硫酸塩 dehydroepiandrosterone and its sulfate
- 4. 子癇前症：管理および予後 preeclampsia management and prognosis
- 5. 小児蘇生法における第一選択剤 primary drugs in pediatric resuscitation
English Journal
- Analysis of micronomicin by liquid chromatography with pulsed electrochemical detection.
- Yuan Y1, Chopra S, Deng X, Zhang M, Fan X, Hu C, Jin S, Van Schepdael A, Adams E.Author information 1Jiang Su Institute for Food and Drug Control, Nanjing 210008, China.AbstractThis paper describes the separation of the main component micronomicin from its related substances using a new established liquid chromatographic method with pulsed electrochemical detection (LC-PED). The mobile phase consists of 1 volume of acetonitrile and 99 volumes of an aqueous solution containing 1.25% (v/v) trifluoroacetic acid, 0.025% (v/v) pentafluoropropionic acid and 0.85% (v/v) of 50% sodium hydroxide. The pH of the aqueous solution is adjusted to 2.6 with 0.5 M NaOH. The influence of the different chromatographic parameters on the separation was investigated. A quadruple-potential waveform was used as detection waveform. 0.5 M NaOH was added post column at a flow rate of 0.3 mL/min to raise the pH of detection to at least 12. The LOD and LOQ of micronomicin are 0.08 μg/mL (1.6 ng injected) and 0.25 μg/mL (5 ng injected), respectively. The linearity of micronomicin ranges from 0.25 to 60 μg/mL with a correlation coefficient of 0.9978. Intra-day RSD and inter-day RSD of micronomicin are 0.89% and 0.55%, respectively. This method proved to be robust and is also applicable to a wider number of C18 columns. A number of commercial samples of micronomicin sulfate were analyzed using this method and 18 peaks can be separated from the main component and from each other in one sample. Seven peaks could be identified using reference substances. The chemical structure of two unknown impurities could be characterized by LC-MS based on comparison of their fragmentation patterns with those of available reference substances.
- Journal of chromatography. A.J Chromatogr A.2013 Jun 21;1295:90-8. doi: 10.1016/j.chroma.2013.04.059. Epub 2013 Apr 27.
- This paper describes the separation of the main component micronomicin from its related substances using a new established liquid chromatographic method with pulsed electrochemical detection (LC-PED). The mobile phase consists of 1 volume of acetonitrile and 99 volumes of an aqueous solution contain
- PMID 23683397
- Impurity profiling of micronomicin sulfate injection by liquid chromatography-ion trap mass spectrometry.
- Yuan YZ1, Zhao X, Zhang M, Fan XL, Hu CQ, Jin SH, Van Schepdael A, Hoogmartens J, Adams E.Author information 1Jiang Su Institute for Food and Drug Control, Nanjing 210008, China.AbstractThe characterization of impurities present in micronomicin sulfate injection by liquid chromatography (LC) coupled with mass spectrometry (MS) is described. A reversed phase (RP)-LC method using a C₁₈ column resistant to an alkaline (pH 11) aqueous mobile phase was developed and coupled to MS with an electrospray ionization (ESI) source in the positive ion mode which provides MS(n) capability. A total of thirty six impurities were detected in commercial samples: five impurities were identified by comparison of their fragmentation patterns with those of available related substances, eleven of them were identified in accordance with relevant literature, while the other twenty impurities were newly identified using the MS/MS spectra of the available related reference substances as interpretative templates combined with knowledge of the nature of functional group fragmentation behaviors. This work was applied to evaluate the quality of micronomicin sulfate injection from different manufacturers.
- Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2013 Mar 5;75:94-104. doi: 10.1016/j.jpba.2012.11.029. Epub 2012 Nov 27.
- The characterization of impurities present in micronomicin sulfate injection by liquid chromatography (LC) coupled with mass spectrometry (MS) is described. A reversed phase (RP)-LC method using a C₁₈ column resistant to an alkaline (pH 11) aqueous mobile phase was developed and coupled to MS wi
- PMID 23261805
- [Comparison of minimum inhibitory concentration and postantibiotic effect of eyedrops on isolates in National Surveillance of Infectious Keratitis in Japan].
- Sunada A1, Ueda A, Inoue Y, Ohashi Y, Uno T, Kitagawa K, Hatano H, Shiota H, Asari S.Author information 1Department of Medical Technology, Osaka University Hospital. 2-15 Yamadaoka, Suita 565 0871, Japan. acchan@hp-lab.med.osaka-u.ac.jpAbstractPURPOSE: To determine the minimum inhibitory concentration (MIC) and postantibiotic effect (PAE) of antibiotic eyedrops against various isolates from infectious keratitis samples.
- Nippon Ganka Gakkai zasshi.Nihon Ganka Gakkai Zasshi.2006 Dec;110(12):973-83.
- PURPOSE: To determine the minimum inhibitory concentration (MIC) and postantibiotic effect (PAE) of antibiotic eyedrops against various isolates from infectious keratitis samples.METHOD: MIC and postantibiotic bactericidal effect (PABE)/postantibiotic fungicidal effect (PAFE) after 4 min of exposure
- PMID 17228760
Japanese Journal
- Neuromuscular Blocking Actions of the Aminoglycoside Antibiotics Sisomicin and Micronomicin in the Rabbit
- Tohoku journal of experimental medicine 181(4), 471-473, 1997-04-01
- NAID 10024506783
- Barium Sulfate Crystals in Parenteral Solutions of Aminoglycoside Antibiotics(Pharmaceutical)
- Chemical and Pharmaceutical Bulletin 35(3), 1223-1227, 1987-03-25
- NAID 110006281036
- Micronomicin点滴静注の臨床的検討尿路感染症について
- The Japanese Journal of Antibiotics 37(1), 122-135, 1984
- NAID 130004130450
Related Links
- Micronomicin is an aminoglycoside antibiotic, and like others in its class, binds to the ribosomes of non-resistant cells causing mistranscription of mRNA which fatally inhibits production of essential proteins.
- Micronomicin Sulfate is a medicine available in a number of countries worldwide. A list of US medications equivalent to Micronomicin Sulfate is available on the Drugs.com website. ... Drugs.com provides accurate and independent ...
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★リンクテーブル★
| リンク元 | 「ミクロノマイシン」「硫酸ミクロノマイシン」 |
| 関連記事 | 「sulfate」「sulfated」「sulfa」 |
「ミクロノマイシン」
「硫酸ミクロノマイシン」
「sulfate」
- n.
- 関
- H2SO4、inorganic sulfate、sulfate ester、sulfated、sulfation、sulfuric acid、sulfuric acid ester、sulphate、sulphuric acid
「sulfated」
- adj.
- 硫酸化の