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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/19 15:33:03」(JST)

Micronomicin (INN) is an aminoglycoside antibiotic for use on the eye.^[1]^[2]

References

^ Odakura, Y.; Kase, H.; Nakayama, K. (1983). "Sagamicin and the related aminoglycosides: Fermentation and biosynthesis. III. Isolation and characterization of Micromonospora sagamiensis mutants blocked in gentamicin C1 pathway". The Journal of antibiotics 36 (2): 125–130. doi:10.7164/antibiotics.36.125. PMID 6833127.
^ Fukuda, M.; Sasaki, K. (2002). "Antibiotic ophthalmic solutions evaluated by pharmacokinetic parameters of maximum concentration in the aqueous". Nippon Ganka Gakkai zasshi 106 (4): 195–200. PMID 11979978.

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Analysis of micronomicin by liquid chromatography with pulsed electrochemical detection.

Yuan Y1, Chopra S, Deng X, Zhang M, Fan X, Hu C, Jin S, Van Schepdael A, Adams E.
Journal of chromatography. A.J Chromatogr A.2013 Jun 21;1295:90-8. doi: 10.1016/j.chroma.2013.04.059. Epub 2013 Apr 27.
This paper describes the separation of the main component micronomicin from its related substances using a new established liquid chromatographic method with pulsed electrochemical detection (LC-PED). The mobile phase consists of 1 volume of acetonitrile and 99 volumes of an aqueous solution contain
PMID 23683397

Femtosecond laser-based mutagenesis strategy for micronomicin production enhancement of Micromonospora sagamiensis ATCC 21826.

Liu P1, Wen J, Chen Y, Jia X.
World journal of microbiology & biotechnology.World J Microbiol Biotechnol.2013 Jun;29(6):1121-7. doi: 10.1007/s11274-013-1261-0. Epub 2013 Jan 25.
In this work, a mutant MX3004 with improved micronomicin (MCR) production was derived from Micromonospora sagamiensis ATCC21826, which was treated with femtosecond laser under the optimized irradiation conditions of 75 mW and 180 s, with a maximum of positive mutation rate of 17.8 % and the mortalit
PMID 23355136

Impurity profiling of micronomicin sulfate injection by liquid chromatography-ion trap mass spectrometry.

Yuan YZ1, Zhao X, Zhang M, Fan XL, Hu CQ, Jin SH, Van Schepdael A, Hoogmartens J, Adams E.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2013 Mar 5;75:94-104. doi: 10.1016/j.jpba.2012.11.029. Epub 2012 Nov 27.
The characterization of impurities present in micronomicin sulfate injection by liquid chromatography (LC) coupled with mass spectrometry (MS) is described. A reversed phase (RP)-LC method using a C₁₈ column resistant to an alkaline (pH 11) aqueous mobile phase was developed and coupled to MS wi
PMID 23261805

Acetylation of Aminoglycoside Antibiotics with 6'-Methylamino Group, Istamycin B and Micronomicin, by a Novel Aminoglycoside 6'-Acetyltransferase of Actinomycete Origin

Acetylation of Aminoglycoside Antibiotics with 6'-Methylamino Group, Istamycin B and Micronomicin, by a Novel Aminoglycoside 6'-Acetyltransferase of Actinomycete Origin.

リンク元	「ミクロノマイシン」
拡張検索	「micronomicin sulfate」

Micronomicin
Systematic (IUPAC) name
	(1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-α-D-erythro-hexopyranoside
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Eye drops, IV
Legal status	℞ (Prescription only);
Identifiers
CAS Number	52093-21-7
ATC code	S01AA22 (WHO)
PubChem	CID 107677
ChemSpider	2301017
UNII	S9AZ0R40QV
KEGG	D08219
Synonyms	(2R,3R,4R,5R)-2-[(1S,2S,4S,6R)-4,6-diamino-3-[(2R,3R,6S)-3-amino-6-(methylaminomethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-methylaminooxane-3,5-diol
Chemical data
Formula	C20H41N5O7
Molar mass	463.56 g/mol
	SMILES C[C@@]1(CO[C@@H]([C@@H]([C@H]1NC)O)O[C@H]2[C@@H](C[C@@H](C([C@@H]2O)O[C@@H]3[C@@H](CC[C@H](O3)CNC)N)N)N)O ;
	InChI InChI=1S/C20H41N5O7/c1-20(28)8-29-19(14(27)17(20)25-3)32-16-12(23)6-11(22)15(13(16)26)31-18-10(21)5-4-9(30-18)7-24-2/h9-19,24-28H,4-8,21-23H2,1-3H3/t9-,10+,11-,12+,13-,14+,15+,16-,17+,18+,19+,20-/m0/s1 ; Key:DNYGXMICFMACRA-XHEDQWPISA-N ;
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