WordNet

the practical application of science to commerce or industry (同)engineering

PrepTutorEJDIC

科学技術,工業技術・科学(工業)技術的な方法(過程)・文明の環境利用(開発)・応用科学; 専門用語

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/07/25 08:42:34」(JST)

wiki en

A Venn diagram outlining and contrasting some aspects of the fields of bio-MEMS, lab-on-a-chip, μTAS.

Find more about Microarray at Wikipedia's sister projects
	Definitions and translations from Wiktionary
	Learning resources from Wikiversity
	Textbooks from Wikibooks

A microarray is a multiplex lab-on-a-chip. It is a 2D array on a solid substrate (usually a glass slide or silicon thin-film cell) that assays large amounts of biological material using high-throughput screening methods. The concept and methodology of microarrays was first introduced and illustrated in antibody microarrays (also referred to as antibody matrix) in 1983 in a scientific publication^[1] and a series of patents.^[2] As the "gene chip" industry started to grow in the 1990's, with the establishment of companies, such as Affymetrix, Illumina, and others, the technology of DNA microarrays has become the most sophisticated and the most widely used.

Types of microarrays include:

DNA microarrays, such as cDNA microarrays, oligonucleotide microarrays and SNP microarrays
MMChips, for surveillance of microRNA populations
Protein microarrays
Peptide microarrays, for detailed analyses or optimization of protein-protein interactions
Tissue microarrays
Cellular microarrays (also called transfection microarrays)
Chemical compound microarrays
Antibody microarrays
Carbohydrate arrays (glycoarrays)
Phenotype microarrays
interferometric reflectance imaging sensor (IRIS)

People in the field of CMOS biotechnology are developing new kinds of microarrays. Once fed magnetic nanoparticles, individual cells can be moved independently and simultaneously on a microarray of magnetic coils. A microarray of nuclear magnetic resonance microcoils is under development. ^[3]

Notes[edit]

^ Chang TW (December 1983). "Binding of cells to matrixes of distinct antibodies coated on solid surface". J. Immunol. Methods 65 (1-2): 217–23. PMID 6606681.
^ http://www.google.com/patents/US4591570; http://www.google.com/patents/US4829010; http://www.google.com/patents/US5100777.
^ Donhee Ham and Robert M. Westervelt. "The Silicon that Moves and Feels Small Living Things". IEEE Solid-state circuits society news. 2007.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 遺伝学およびゲノミクスのためのツール：遺伝子発現プロファイリング tools for genetics and genomics gene expression profiling
2. 血液悪性腫瘍における細胞遺伝子解析の一般的側面 general aspects of cytogenetic analysis in hematologic malignancies
3. 死産の評価 evaluation of stillbirth
4. 食物アレルギーに対する今後の診断ツール future diagnostic tools for food allergy
5. マントル細胞リンパ腫の病理学 pathobiology of mantle cell lymphoma

English Journal

Cardioprotective effects of salvianolic Acid a on myocardial ischemia-reperfusion injury in vivo and in vitro.

Fan H, Yang L, Fu F, Xu H, Meng Q, Zhu H, Teng L, Yang M, Zhang L, Zhang Z, Liu K.SourceSchool of Pharmacy, Yantai University, Yantai 264005, China.
Evidence-based complementary and alternative medicine : eCAM.Evid Based Complement Alternat Med.2012;2012:508938. Epub 2011 Jun 25.
Salvianolic acid A (SAA), one of the major active components of Danshen that is a traditional Chinese medicine, has been reported to possess protective effect in cardiac diseases and antioxidative activity. This study aims to investigate the cardioprotection of SAA in vivo and in vitro using the mod
PMID 21789047

Japanese Journal

Microintaglio Printing of Biomolecules and Its Application to In situ Production of Messenger Ribonucleic Acid Display Microarray

Biyani Manish,Osawa Terutsune,Nemoto Naoto [他],Ichiki Takanori
Applied Physics Express 4(4), 047001-047001-3, 2011-04-25
… A new molecular printing technology for a simple and robust patterning of biomolecules was developed and applied to producing a genotype-linked protein microarray. … A microarray of messenger ribonucleic acids (mRNAs) encoding the green fluorescent protein was patterned by microintaglio printing using a micromold comprising an array of uniformly arranged 5-μm-diameter holes at a density of 10,000 per mm2. …
NAID 150000001203