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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/28 12:12:36」(JST)

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Mezlocillin is a broad-spectrum penicillin antibiotic. It is active against both Gram-negative and some Gram-positive bacteria. Unlike most other extended spectrum penicillins, it is excreted by the liver, therefore it is useful for biliary tract infections, such as ascending colangitis.

Mechanism of action

Like all other beta-lactam antibiotics, mezlocillin inhibits the third and last stage of bacterial cell wall synthesis by binding to penicillin binding proteins. This ultimately leads to cell lysis.

Susceptible organisms

Gram-negative

Bacteroides spp., including B. fragilis
Enterobacter spp.
Escherichia coli
Haemophilus influenzae
Klebsiella species
Morganella morganii
Neisseria gonorrhoeae
Proteus mirabilis
Proteus vulgaris
Providencia rettgeri
Pseudomonas spp., including P. aeruginosa
Serratia marcescens

Gram-positive

Enterococcus faecalis
Peptococcus spp.
Peptostreptococcus spp.

External links

DDB 30377
-288358398 at GPnotebook
Duke
Kristof R, Clusmann H, Koehler W, Fink K, Schramm J (1998). "Treatment of accidental high dose intraventricular mezlocillin application by cerebrospinal fluid exchange.". J Neurol Neurosurg Psychiatry 64 (3): 379–81. doi:10.1136/jnnp.64.3.379. PMC 2170014. PMID 9527154.
McCormick P, Greenslade L, Kibbler C, Chin J, Burroughs A, McIntyre N (1997). "A prospective randomized trial of ceftazidime versus netilmicin plus mezlocillin in the empirical therapy of presumed sepsis in cirrhotic patients.". Hepatology 25 (4): 833–6. doi:10.1002/hep.510250408. PMID 9096584.
Rohde B, Werner U, Hickstein H, Ehmcke H, Drewelow B (1997). "Pharmacokinetics of mezlocillin and sulbactam under continuous veno-venous hemodialysis (CVVHD) in intensive care patients with acute renal failure.". Eur J Clin Pharmacol 53 (2): 111–5. doi:10.1007/s002280050347. PMID 9403281.

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UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. ペニシリン penicillins
2. 慢性化膿性中耳炎（CSOM）：予防、治療、予後、および合併症 chronic suppurative otitis media csom prevention treatment prognosis and complications
3. 無石胆嚢炎 acalculous cholecystitis

English Journal

Prevalence of Extended Spectrum β-lactamase-Producing Klebsiella pneumoniae in Clinical Isolates.

Ali Abdel Rahim KA1, Ali Mohamed AM2.
Jundishapur journal of microbiology.Jundishapur J Microbiol.2014 Nov;7(11):e17114. doi: 10.5812/jjm.17114. Epub 2014 Nov 1.
BACKGROUND: Extended spectrum β-lactamase (ESBL) are gram-negative bacteria that produce the enzyme, β-lactamase, which can break down commonly used antibiotics, such as penicillin and cephalosporins, making infections with ESBL producing bacteria more difficult to treat. Extended spectrum β-lact
PMID 25774279

[Using intracameral cefuroxime reduces postoperative endophthalmitis rate: 5 years experience at the University Eye Hospital Tübingen].

Röck T1, Bramkamp M2, Bartz-Schmidt KU1, Mutlu U1, Yörük E1, Röck D1, Thaler S1.
Klinische Monatsblätter für Augenheilkunde.Klin Monbl Augenheilkd.2014 Oct;231(10):1023-8. doi: 10.1055/s-0034-1383013. Epub 2014 Oct 21.
BACKGROUND: Cataract surgery is the most commonly performed surgical procedure in developed countries. The annual number of cataract surgeries in Germany is about 600,000. Acute postoperative endophthalmitis is a very severe and the most dreaded complication of cataract surgery. Various operative an
PMID 25333241

Isolation and characterization of numerous novel phages targeting diverse strains of the ubiquitous and opportunistic pathogen Achromobacter xylosoxidans.

Wittmann J1, Dreiseikelmann B2, Rohde C1, Rohde M3, Sikorski J4.
PloS one.PLoS One.2014 Jan 22;9(1):e86935. doi: 10.1371/journal.pone.0086935. eCollection 2014.
The clinical relevance of nosocomially acquired infections caused by multi-resistant Achromobacter strains is rapidly increasing. Here, a diverse set of 61 Achromobacter xylosoxidans strains was characterized by MultiLocus Sequence Typing and Phenotype MicroArray technology. The strains were further
PMID 24466294

Japanese Journal

Prospective randomized comparison of mezlocillin therapy alone with combined ampicillin and gentamicin therapy for patients with cholangitis

GERECHT W
Arch Intern Med 149, 1279-1284, 1989
NAID 30005426703

Cefoperazone plus mezlocillin for empiric therapy of febrile cancer patients

JONES P.
Am J Med 85(Suppl 1A), 3-8, 1988
NAID 30008560511

エルシニアのβ-ラクタム系抗生物質に対する感受性

金城俊夫 [他],武藤照美,木原正子,源宜之
岐阜大学農学部研究報告 51, 219-225, 1987-01-10
エルシニアはY. pseudotuberculosisを除きβ-ラクタマーゼを産生する。このβ-ラクタマーゼ産生能に,エルシニアの菌種,生物型あるいは血清型によって,これらの分類の一助となりうるような差があるか否かを検討するため,各菌種のβ-ラクタム系抗生物質に対する感受性試験を行った。ヒト及び各種動物由来のY. enterocolitica B:1 81株,B:2 10株,B:3 30株,B:4 …
NAID 110000976529

Related Pictures

★リンクテーブル★

リンク元	「メズロシリン」「MZPC」
拡張検索	「mezlocillin sodium」

「メズロシリン」

Mezlocillin
Systematic (IUPAC) name
	(2S,5R,6R)-3,3-dimethyl-6-[[(2R)-2-[(3-methylsulfonyl-; 2-oxo-imidazolidine-1-carbonyl)amino]-2-phenyl-acetyl]; amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-; carboxylic acid
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy; category	B;
Routes of; administration	Intravenous, intramuscular
Pharmacokinetic data
Protein binding	16–59%
Metabolism	Hepatic (20–30%)
Half-life	1.3–4.4 hours
Excretion	Renal (50%) and biliary
Identifiers
CAS Registry Number	51481-65-3
ATC code	J01CA10
PubChem	CID 656511
DrugBank	DB00948
ChemSpider	570894
UNII	OH2O403D1G
KEGG	D05021
ChEBI	CHEBI:6919
ChEMBL	CHEMBL1731
Chemical data
Formula	C21H25N5O8S2
Molecular mass	539.584 g/mol
	SMILES O=C(O)[C@@H]3N4C(=O)[C@@H](NC(=O)[C@@H](c1ccccc1)NC(=O)N2C(=O)N(S(=O)(=O)C)CC2)[C@H]4SC3(C)C;
	InChI InChI=1S/C21H25N5O8S2/c1-21(2)14(18(29)30)26-16(28)13(17(26)35-21)22-15(27)12(11-7-5-4-6-8-11)23-19(31)24-9-10-25(20(24)32)36(3,33)34/h4-8,12-14,17H,9-10H2,1-3H3,(H,22,27)(H,23,31)(H,29,30)/t12-,13-,14+,17-/m1/s1 ; Key:YPBATNHYBCGSSN-VWPFQQQWSA-N ;
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