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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/02/22 09:53:06」(JST)

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  • Differential roles of the mevalonate pathway in the development and survival of mouse purkinje cells in culture.
  • Barszczyk A1, Sun HS, Quan Y, Zheng W, Charlton MP, Feng ZP.
  • Molecular neurobiology.Mol Neurobiol.2015 Jun;51(3):1116-29. doi: 10.1007/s12035-014-8778-6. Epub 2014 Jun 29.
  • The cerebellum is an important locus for motor learning and higher cognitive functions, and Purkinje cells constitute a key component of its circuit. Biochemically, significant turnover of cholesterol occurs in Purkinje cells, causing the activation of the mevalonate pathway. The mevalonate pathway
  • PMID 24973985
  • Sterol liganding of OSBP-related proteins (ORPs) regulates the subcellular distribution of ORP-VAPA complexes and their impacts on organelle structure.
  • Kentala H1, Pfisterer SG2, Olkkonen VM3, Weber-Boyvat M4.
  • Steroids.Steroids.2015 Feb 11. pii: S0039-128X(15)00056-2. doi: 10.1016/j.steroids.2015.01.027. [Epub ahead of print]
  • Oxysterol-binding protein (OSBP) and its homologues (ORPs) are lipid-binding/transfer proteins with affinity for oxysterols, cholesterol and glycerophospholipids. In addition to a ligand-binding domain, a majority of the ORPs carry a pleckstrin homology domain that targets organelle membranes via ph
  • PMID 25681634
  • [Overexpression of LaeA enhances mevastatin production and reduces sporulation of Penicillium citrinum].
  • Zheng Y, Cao S, Huang Y, Liao G, Hu C.
  • Wei sheng wu xue bao = Acta microbiologica Sinica.Wei Sheng Wu Xue Bao.2014 Dec 4;54(12):1438-45.
  • OBJECTIVE: To study the regulation of laeA overexpression on mevastatin production and sporulation in Penicillium citrinum.METHODS: We cloned the laeA gene from Penicillium citrinum and constructed the vector pGiHTGi-laeA. The plasmid pGiHTGi-laeA was transformed in Penicillium citrinum by agrobacte
  • PMID 25876329


  • Development of natural anti-tumor drugs by microorganisms
  • Chang Chia-Che,Chen Wei-Chuan,Ho Tsing-Fen,Wu Ho-Shing,Wei Yu-Hong
  • Journal of bioscience and bioengineering 111(5), 501-511, 2011-05
  • … The great biodiversity of microorganisms raises the possibility of producing secondary metabolites (e.g., mevastatin, lovastatin, epothilone, salinosporamide A) to cope with adverse environments. …
  • NAID 110008661194
  • Pharmacological Topics of Bone Metabolism : Antiresorptive Microbial Compounds That Inhibit Osteoclast Differentiation, Function, and Survival
  • WOO Je-Tae,YONEZAWA Takayuki,CHA Byung-Yoon,TERUYA Toshiaki,NAGAI Kazuo
  • Journal of pharmacological sciences 106(4), 547-554, 2008-04-20
  • … As a result, we identified reveromycin A, destruxins, mevastatin, FK506, cyclosporin A, prodigiosins, concanamycins, and symbioimine among microbial natural compounds. …
  • NAID 10024319737
  • ジャスモン酸とそのアミド誘導体によってイヌタデ葉から放出される揮発性セスキテルペン
  • 田母神 繁,成田 泰洋,鈴木 成治,西澤 知之,花井 秀俊,野間 正名
  • Journal of pesticide science = 日本農薬学会誌 32(3), 264-269, 2007-08-20
  • セスキテルペンの,ジンギベレン,β-エレメン,α-ベルガモテン,β-カリオフイレン, (E,E)-α-ファルネセンなどを,ジャスモン酸で処理されたイヌタデ葉が放出する植物揮発性物質として同定した.これらのセスキテルペンは1μMの濃度で放出され,相対的な放出量は濃度によって変化した.チオ硫酸銀を使った実験から放出にはエチレンが関与することが示唆された.また,チオ硫酸銀の効果はセスキテルペン間で異なっ …
  • NAID 110006379898


Mevastatin, compactin, ML-236B is a hypolipidemic agent that belongs to the statins class. ... Mevastatin might be considered the first statin drug, but, although clinical trials on mevastatin were performed in the late 1970s in Japan, it was never ...
2008年9月15日 ... メバスタチン(mevastatin)は、スタチン系薬物のプロトタイプ...