関: metipranolol hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/21 07:49:48」(JST)

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Metipranolol (OptiPranolol, Betanol, Disorat, Trimepranol) is a non-selective beta blocker used in eye drops to treat glaucoma. It is rapidly metabolized into desacetylmetipranolol.^[1]

References

^ Maffei Facino, R.; Bertuletti, R.; Carini, M.; Tofanetti, O. (1980). "In vitro metabolism of methypranolol by rat liver". Analytical Chemistry Symposia Series 4 (6): 217–223.

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1. 原発性乳児緑内障 primary infantile glaucoma

English Journal

Treatment of central serous chorioretinopathy with beta-blocker metipranolol.

Chrapek O1, Jirkova B, Kandrnal V, Rehak J, Sin M.
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia.Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub.2015 Mar;159(1):120-3. doi: 10.5507/bp.2013.015. Epub 2013 Mar 21.
AIM: The purpose of this study was to evaluate the effect of the systemically administered betablocker metipranolol on the course of central serous chorioretinopathy (CSC).METHODS: A prospective double-blind study involving 48 patients with a first attack of CSC not exceeding two weeks and who agree
PMID 23549516

Drug-induced uveitis.

Cordero-Coma M1, Salazar-Méndez R, Garzo-García I, Yilmaz T.
Expert opinion on drug safety.Expert Opin Drug Saf.2015 Jan;14(1):111-26. doi: 10.1517/14740338.2015.972363. Epub 2014 Oct 17.
INTRODUCTION: Drug-induced uveitis is a well described but often overlooked and/or misdiagnosed adverse reaction to medication. There are an increasing number of medications that have been related to the onset of intraocular inflammation. Identification of these inciting agents may decisively help t
PMID 25323655

Novel pluronic-chitosan micelle as an ocular delivery system.

Lin HR1, Chang PC.
Journal of biomedical materials research. Part B, Applied biomaterials.J Biomed Mater Res B Appl Biomater.2013 Jul;101(5):689-99. doi: 10.1002/jbm.b.32871. Epub 2013 Jan 29.
Pluronic micelles were prepared for ophthalmic delivery by incorporation of ethyl acetate as a dispersion agent and their surfaces were modified by chitosan to improve their bioavailability. The micelles disperse well in the solution and have a core-shell like structure with a particle size ranging
PMID 23359519

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Metipranolol
Systematic (IUPAC) name
	(RS)-4-{[-2-hydroxy-3-(isopropylamino)propyl]oxy}-2,3,6-trimethylphenyl acetate
Clinical data
Trade names	Optipranolol
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a601078
Identifiers
CAS Number	22664-55-7
ATC code	S01ED04 C07BA68
PubChem	CID: 31477
IUPHAR/BPS	7239
DrugBank	DB01214
ChemSpider	29193
UNII	X39AL81KEB
KEGG	D02374
ChEMBL	CHEMBL1291
Chemical data
Formula	C17H27NO4
Molecular mass	309.401 g/mol
	SMILES O=C(Oc1c(c(c(OCC(O)CNC(C)C)cc1C)C)C)C ;
	InChI InChI=1S/C17H27NO4/c1-10(2)18-8-15(20)9-21-16-7-11(3)17(22-14(6)19)13(5)12(16)4/h7,10,15,18,20H,8-9H2,1-6H3 ; Key:BQIPXWYNLPYNHW-UHFFFAOYSA-N ;
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