メチルヒスチジン
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English Journal
- Biological system responses to zearalenone mycotoxin exposure by integrated metabolomic studies.
- Liu G, Yan T, Wang J, Huang Z, Chen X, Jia G, Wu C, Zhao H, Xue B, Xiao L, Tang J.Author information Institute of Animal Nutrition, Sichuan Agricultural University , Chengdu 611130, Sichuan, China.AbstractThis study aims to investigate the effect of zearalenone supplementation on rat metabolism. Rats received biweekly intragastric administration of zearalenone mycotoxin (3 mg/kg body weight) for 2 weeks. Urine and plasma samples after zearalenone administration were analyzed by NMR-based metabolomics. Zearalenone exposure significantly elevated the plasma levels of glucose, lactate, N-acetyl glycoprotein, O-acetyl glycoprotein, and propionate but reduced the plasma levels of tyrosine, branched-chain amino acids, and choline metabolites. Zearalenone supplementation decreased the urine levels of butyrate, lactate, and nicotinate. However, it increased the urine levels of allantoin, choline, and N-methylnicotinamide at 0-8 h after the last zearalenone administration and those of 1-methylhistidine, acetoacetate, acetone, and indoxyl sulfate at 8-24 h after the last zearalenone administration. These results suggest that zearalenone exposure can cause oxidative stress and change common systemic metabolic processes, including cell membrane metabolism, protein biosynthesis, glycolysis, and gut microbiota metabolism.
- Journal of agricultural and food chemistry.J Agric Food Chem.2013 Nov 20;61(46):11212-21. doi: 10.1021/jf403401v. Epub 2013 Nov 6.
- This study aims to investigate the effect of zearalenone supplementation on rat metabolism. Rats received biweekly intragastric administration of zearalenone mycotoxin (3 mg/kg body weight) for 2 weeks. Urine and plasma samples after zearalenone administration were analyzed by NMR-based metabolomics
- PMID 24164354
- TNFα altered inflammatory responses, impaired health and productivity, but did not affect glucose or lipid metabolism in early-lactation dairy cows.
- Yuan K, Farney JK, Mamedova LK, Sordillo LM, Bradford BJ.Author information Department of Animal Sciences and Industry, Kansas State University, Manhattan, Kansas, United States of America.AbstractInflammation may be a major contributing factor to peripartum metabolic disorders in dairy cattle. We tested whether administering an inflammatory cytokine, recombinant bovine tumor necrosis factor-α (rbTNFα), affects milk production, metabolism, and health during this period. Thirty-three Holstein cows (9 primiparous and 24 multiparous) were randomly assigned to 1 of 3 treatments at parturition. Treatments were 0 (Control), 1.5, or 3.0 µg/kg body weight rbTNFα, which were administered once daily by subcutaneous injection for the first 7 days of lactation. Statistical contrasts were used to evaluate the treatment and dose effects of rbTNFα administration. Plasma TNFα concentrations at 16 h post-administration tended to be increased (P<0.10) by rbTNFα administration, but no dose effect (P>0.10) was detected; rbTNFα treatments increased (P<0.01) concentrations of plasma haptoglobin. Most plasma eicosanoids were not affected (P>0.10) by rbTNFα administration, but 6 out of 16 measured eicosanoids changed (P<0.05) over the first week of lactation, reflecting elevated inflammatory mediators in the days immediately following parturition. Dry matter and water intake, milk yield, and milk fat and protein yields were all decreased (P<0.05) by rbTNFα treatments by 15 to 18%. Concentrations of plasma glucose, insulin, β-hydroxybutyrate, non-esterified fatty acids, triglyceride, 3-methylhistidine, and liver triglyceride were unaffected (P>0.10) by rbTNFα treatment. Glucose turnover rate was unaffected (P=0.18) by rbTNFα administration. The higher dose of rbTNFα tended to increase the risk of cows developing one or more health disorders (P=0.08). Taken together, these results indicate that administration of rbTNFα daily for the first 7 days of lactation altered inflammatory responses, impaired milk production and health, but did not significantly affect liver triglyceride accumulation or nutrient metabolism in dairy cows.
- PloS one.PLoS One.2013 Nov 19;8(11):e80316. doi: 10.1371/journal.pone.0080316.
- Inflammation may be a major contributing factor to peripartum metabolic disorders in dairy cattle. We tested whether administering an inflammatory cytokine, recombinant bovine tumor necrosis factor-α (rbTNFα), affects milk production, metabolism, and health during this period. Thirty-three Holstei
- PMID 24260367
- Distinct metabolic profile of primary focal segmental glomerulosclerosis revealed by NMR-based metabolomics.
- Hao X, Liu X, Wang W, Ren H, Xie J, Shen P, Lin D, Chen N.Author information Nephrology Department, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.AbstractBACKGROUND: Primary focal segmental glomerulosclerosis (FSGS) is pathological entity which is characterized by idiopathic steroid-resistant nephrotic syndrome (SRNS) and progression to end-stage renal disease (ESRD) in the majority of affected individuals. Currently, there is no practical noninvasive technique to predict different pathological types of glomerulopathies. In this study, the role of urinary metabolomics in the diagnosis and pathogenesis of FSGS was investigated.
- PloS one.PLoS One.2013 Nov 11;8(11):e78531. doi: 10.1371/journal.pone.0078531.
- BACKGROUND: Primary focal segmental glomerulosclerosis (FSGS) is pathological entity which is characterized by idiopathic steroid-resistant nephrotic syndrome (SRNS) and progression to end-stage renal disease (ESRD) in the majority of affected individuals. Currently, there is no practical noninvasiv
- PMID 24244321
Japanese Journal
- 乳牛における分娩後の蛋白質栄養状態を示す指標としての血中3-メチルヒスチジンの有用性検討
- Synergistic Effect of Feeding Aspergillus Awamori and Saccharomyces Cerevisiae on Growth Performance in Broiler Chickens; Promotion of Protein Metabolism and Modification of Fatty acid Profile in the Muscle
- A. Saleh Ahmed,Hayashi Kunioki,Ohtsuka Akira
- The Journal of Poultry Science 50(3), 242-250, 2013
- … Plasma 3-methylhistidine concentrations were decreased by A. …
- NAID 130004446397
- Dibutoxybutane Suppresses Protein Degradation and Promotes Growth in Cultured Chicken Muscle Cells
- Kamizono Tomomi,Ohtsuka Akira,Hashimoto Fumio,Hayashi Kunioki
- The Journal of Poultry Science 50(1), 37-43, 2013
- … The muscle cell growth was accelerated and the rate of protein degradation estimated from Nτ-methylhistidine release into the medium was decreased by DBB. …
- NAID 130004446384
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