methylenetetrahydrofolate dehydrogenase

• メチレンテトラヒドロ葉酸脱水素酵素、メチレンテトラヒドロ葉酸デヒドロゲナーゼ

• 5,10-methylenetetrahydrofolate dehydrogenase

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• 1. ホモシステインの概要overview of homocysteine [show details]
  …population is heterozygous for the thermolabile variant of MTHFR and 10 percent is homozygous . Homozygosity for the thermolabile variant of MTHFR (TT genotype) is a relatively common cause of elevated plasma …
• 2. 妊娠中の葉酸補充folic acid supplementation in pregnancy [show details]
  …liver disease, renal failure requiring dialysis, and ethanol abuse). Methylenetetrahydrofolate reductase (MTHFR) polymorphisms (eg, MTHFR 677C->T or 677TT). Normal serum and red cell folate levels by trimester …
• 3. 症状のない成人への先天性血栓性素因のスクリーニングscreening for inherited thrombophilia in asymptomatic adults [show details]
  …fasting plasma homocysteine levels or for assaying for presence of the methylenetetrahydrofolate reductase (MTHFR) 677C—>T, MTHFR 1298 A—>C, or plasminogen activator inhibitor-1 (PAI-1) 4G/5G promoter …
• 4. ビタミンB12欠乏や葉酸欠乏の原因と病態生理causes and pathophysiology of vitamin b12 and folate deficiencies [show details]
  … which is converted to L-5-methyl-THF by the enzyme methylenetetrahydrofolate reductase.… laboratory findings of hemolysis, including elevated serum iron, indirect bilirubin, and lactate dehydrogenase (LDH), and low haptoglobin. The reticulocyte count is low. Vitamin B12 deficiency is known to …
• 5. 妊娠中の先天性血栓性素因inherited thrombophilias in pregnancy [show details]
  …VIII levels in pregnancy with respect to prothrombotic risk. Homozygosity for methylenetetrahydrofolate reductase (MTHFR) polymorphisms (C677T, 1298C) is a relatively common cause of mildly elevated plasma …

English Journal

• Common Polymorphisms That Affect Folate Transport or Metabolism Modify the Effect of the MTHFR 677C > T Polymorphism on Folate Status.

• Bueno O1, Molloy AM2, Fernandez-Ballart JD1, García-Minguillán CJ1, Ceruelo S3, Ríos L4, Ueland PM5, Meyer K6, Murphy MM7.
• The Journal of nutrition.J Nutr.2015 Nov 11. pii: jn223685. [Epub ahead of print]
• BACKGROUND: Although combinations of biologically relevant polymorphic variants affect folate status, most studies have focused on the effects of individual polymorphisms; however, these effects may be altered by interactions between polymorphisms.OBJECTIVE: We sought to investigate the individual a
• PMID 26561410

• Physiological role of methylenetetrahydrofolate dehydrogenase (FolD), methenyl tetrahydrofolate cyclohydrolase (FchA) and formyl tetrahydrofolate synthetase (Fhs) from Clostridium perfringens in a heterologous model of Escherichia coli.

• Aluri S1, Sah S2, Miryala S3, Varshney U4.
• Microbiology (Reading, England).Microbiology.2015 Nov 3. doi: 10.1099/mic.0.000209. [Epub ahead of print]
• Organisms possess bifunctional FolD (5, 10-methylenetetrahydrofolate dehydrogenase/5, 10-methenyltetrahydrofolate cyclohydrolase) to generate NADPH and 10-formyltetrahdrofolate (10-CHO-THF) required in various metabolic steps. In addition, some organisms including Clostridium perfringens possess ano
• PMID 26531681

• Pharmacokinetics and pharmacogenetics of capecitabine and its metabolites following replicate administration of two 500 mg tablet formulations.

• Queckenberg C1,2, Erlinghagen V3, Baken BC4, Van Os SH4, Wargenau M5, Kubeš V6, Peroutka R6, Novotný V6, Fuhr U3.
• Cancer chemotherapy and pharmacology.Cancer Chemother Pharmacol.2015 Nov;76(5):1081-91. doi: 10.1007/s00280-015-2840-6. Epub 2015 Aug 5.
• PURPOSE: To describe concentration versus time profiles of capecitabine and its metabolites 5'-DFUR, 5'-DFCR and 5-FU, depending on tablet formulation and on frequent and/or relevant genetic polymorphisms of cytidine deaminase, dihydropyrimidine dehydrogenase, thymidylate synthase and methylenetetra
• PMID 26242222

Japanese Journal

• Role of Ad4-binding protein/steroidogenic factor 1 in regulating NADPH production in adrenocortical Y-1 cells

• Endocrine Journal 64(3), 315-324, 2017
• NAID 130005529460

• Role of Ad4-binding protein/steroidogenic factor 1 in regulating NADPH production in adrenocortical Y-1 cells

• Endocrine Journal, 2017
• NAID 130005332260

• 口腔がんの分子疫学

• 頭頸部癌 33(3), 214-219, 2007
• NAID 130004509950

Related Links

• GO:0004486 methylenetetrahydrofolate dehydrogenase [NAD ...

Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+. 2008-05-12 Deleted DEFINITION Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10 ...

• MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ ...

This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and ...

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★リンクテーブル★

リンク元	「メチレンテトラヒドロ葉酸脱水素酵素」「メチレンテトラヒドロ葉酸デヒドロゲナーゼ」
拡張検索	「5,10-methylenetetrahydrofolate dehydrogenase」
関連記事	「methylenetetrahydrofolate」「dehydrogenase」「dehydrogenases」

「メチレンテトラヒドロ葉酸脱水素酵素」

　　[★]

英

methylenetetrahydrofolate dehydrogenase

関

メチレンテトラヒドロ葉酸デヒドロゲナーゼ

「メチレンテトラヒドロ葉酸デヒドロゲナーゼ」

　　[★]

英

methylenetetrahydrofolate dehydrogenase

関

メチレンテトラヒドロ葉酸脱水素酵素

「5,10-methylenetetrahydrofolate dehydrogenase」

　　[★]

5、5,10-メチレンテトラヒドロ葉酸デヒドロゲナーゼ

「methylenetetrahydrofolate」

　　[★]

• メチレンテトラヒドロ葉酸

• 5,10-methylenetetrahydrofolate

「dehydrogenase」

　　[★] 脱水素酵素 デヒドロゲナーゼ

「dehydrogenases」

　　[★] 脱水素酵素 デヒドロゲナーゼ