WordNet

a glycoside formed by partial hydrolysis of a nucleic acid
having received a methyl group; "methylated alcohol"

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1. プリンヌクレオシドホスホリラーゼ欠損症purine nucleoside phosphorylase deficiency [show details]
… Tandem mass spectrometry (TMS) can be set up to detect elevated levels of purine nucleosides and 2'-deoxy-nucleosides in dried blood spots . The differential diagnosis for PNP deficiency is broad, with …
2. HIVヌクレオシド系逆転写酵素阻害剤のミトコンドリア毒性mitochondrial toxicity of hiv nucleoside reverse transcriptase inhibitors [show details]
…mitochondrial dysfunction by NRTIs, nucleoside analogues can also influence intracellular nucleoside transporters, disturb the delicate balance of the intracellular nucleoside pools, or alter kinetics of phosphorylation …
3. 膠芽腫の診断を受けたばかりの成人への初期治療およびその予後initial treatment and prognosis of newly diagnosed glioblastoma in adults [show details]
…especially in patients with MGMT-methylated tumors (HR 0.65, 95% CI 0.50-0.85), but no difference in overall survival (HR 0.92, 95% CI 0.71-1.19), even in the MGMT-methylated subgroup (HR 0.89, 95% CI 0.63-1 …
4. 未治療HIV感染患者のための抗レトロウイルス療法の選択selecting antiretroviral regimens for the treatment naive hiv infected patient [show details]
…antiretroviral drugs typically used in initial regimens. These include: Nucleoside (and nucleotide) reverse transcriptase inhibitors (NRTIs) Non-nucleoside reverse transcriptase inhibitors (NNRTIs) Protease inhibitors …
5. HIV感染症の治療に用いる抗レトロウイルス薬の概要overview of antiretroviral agents used to treat hiv [show details]
…double-stranded viral DNA product migrates into the nucleus of the cell. Nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs) inhibit the process of …

English Journal

5-Formylcytosine to cytosine conversion by C-C bond cleavage in vivo.

Iwan K1, Rahimoff R1, Kirchner A1, Spada F1, Schröder AS1, Kosmatchev O1, Ferizaj S1, Steinbacher J1, Parsa E1, Müller M1, Carell T1.
Nature chemical biology.Nat Chem Biol.2018 Jan;14(1):72-78. doi: 10.1038/nchembio.2531. Epub 2017 Nov 27.
PMID 29176672

Identification of tRNA nucleoside modification genes critical for stress response and development in rice and Arabidopsis.

Wang Y1,2, Pang C1,2, Li X3, Hu Z1,2, Lv Z1,2, Zheng B4,5, Chen P6,7.
BMC plant biology.BMC Plant Biol.2017 Dec 21;17(1):261. doi: 10.1186/s12870-017-1206-0.
PMID 29268705
PMID 28911863

Japanese Journal

DNA Photocrosslinking Using 3-Vinylcarbazole Derivatives in Two-color Detection of Methylcytosine

Nakamura Shigetaka,Nakajima Ryo,Fujimoto Kenzo
Chemistry Letters 47(7), 875-877, 2018
… The methylated DNA base 5-methylcytosine (mC) is the most important factor in the epigenetic regulation of gene expression. … 3-cyanovinylcarbazole nucleoside (CNVK) photocrosslinks with mC more rapidly than with cytosine (C). …
NAID 130007402740

Cellular Uptake of Decitabine by Equilibrative Nucleoside Transporters in HCT116 Cells

Ueda Kumiko,Hosokawa Mika,Iwakawa Seigo
Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 38(8), 1113-1119, 2015
… Decitabine (DAC), a DNA methyltransferase 1 inhibitor of nucleoside analogues, has been shown to restore gene expression silenced by hypermethylation. … mRNA was the most abundant among the nucleoside transporters examined in HCT116 cells. … The uptake of these agents was inhibited by S-(4-nitrobenzyl)-6-thioinosine (NBMPR), an inhibitor of equilibrative nucleoside transporters (ENTs), and was also decreased in cells treated with ENT1 …
NAID 130005090657

Studies of Phosphorylation. I. Phosphorylation of 2′, 3′-O-Isopropylidene Nucleoside by Phosphoryl Chloride

Yoshikawa Masaharu,Kato Tetsuya
Bulletin of the Chemical Society of Japan 40(12), 2849-2853, 1967
… The undesirable cleavage of the glycosidic linkage in nucleoside, which was observed particularly in a strongly acidic medium caused by the addition of excessive water, could be suppressed by the addition of ethers or amines in a phosphoryl chloride solution. …
NAID 130001963962