English Journal

Glucocorticoids: Dose-related effects on osteoclast formation and function via reactive oxygen species and autophagy.

Shi J1, Wang L1, Zhang H1, Jie Q1, Li X1, Shi Q2, Huang Q1, Gao B1, Han Y1, Guo K1, Liu J3, Yang L4, Luo Z5.
Bone.Bone.2015 Oct;79:222-32. doi: 10.1016/j.bone.2015.06.014. Epub 2015 Jun 24.
Whether glucocorticoids directly enhance or interrupt osteoclastogenesis is still a controversial subject. In this study, we ascertained the dose-dependent positive effects of glucocorticoids on osteoclastogenesis in vivo and in vitro as well as investigated the mechanism in vitro. As the dose of gl
PMID 26115910

A novel cognitive impairment mechanism that astrocytic p-connexin 43 promotes neuronic autophagy via activation of P2X7R and down-regulation of GLT-1 expression in the hippocampus following traumatic brain injury in rats.

Sun L1, Gao J2, Zhao M2, Cui J3, Li Y1, Yang X1, Jing X4, Wu Z5.
Behavioural brain research.Behav Brain Res.2015 Sep 15;291:315-24. doi: 10.1016/j.bbr.2015.05.049. Epub 2015 May 29.
Connexin 43 (Cx43) is one of the major gap junction proteins in astrocytes. Our previous studies reported that astrocytic phosphorylated Cx43 (p-CX43) regulated neuronic autophagy levels in the rat hippocampus after traumatic brain injury (TBI). In this study, we explored the underlying molecular me
PMID 26031379

Sphingosylphosphorylcholine protects cardiomyocytes against ischemic apoptosis via lipid raft/PTEN/Akt1/mTOR mediated autophagy.

Yue HW1, Liu J1, Liu PP2, Li WJ1, Chang F1, Miao JY1, Zhao J3.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Sep;1851(9):1186-93. doi: 10.1016/j.bbalip.2015.04.001. Epub 2015 Apr 12.
Autophagy, evoked by diverse stresses including myocardial ischemia/reperfusion (I/R), profoundly affects the development of heart failure. However, the specific molecular basis of autophagy remains to be elucidated. Here we report that sphingosylphosphorylcholine (SPC), a bioactive sphingolipid, si
PMID 25871970

Japanese Journal

Intrathecal Injection of 3-Methyladenine Reduces Neuronal Damage and Promotes Functional Recovery via Autophagy Attenuation after Spinal Cord Ischemia/Reperfusion Injury in Rats