メチクロチアジド
- 関
- Thiazide diuretics
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/10/28 06:14:34」(JST)
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Methyclothiazide
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Systematic (IUPAC) name |
6-Chloro-3-(chloromethyl)-2-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
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Clinical data |
AHFS/Drugs.com |
Consumer Drug Information |
MedlinePlus |
a682569 |
Identifiers |
CAS Registry Number |
135-07-9 Y |
ATC code |
C03AA08 |
PubChem |
CID: 4121 |
IUPHAR/BPS |
7235 |
DrugBank |
DB00232 N |
ChemSpider |
3978 N |
UNII |
L3H46UAC61 N |
KEGG |
D00656 N |
ChEMBL |
CHEMBL1577 N |
Chemical data |
Formula |
C9H11Cl2N3O4S2 |
Molecular mass |
360.24 g/mol |
N (what is this?) (verify) |
Methyclothiazide is a thiazide diuretic.
References
Symporter inhibitors
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Sodium chloride |
- thiazide: Bendroflumethiazide
- Chlorothiazide
- Cyclopenthiazide
- Cyclothiazide
- Hydrochlorothiazide
- Hydroflumethiazide
- Methyclothiazide
- Polythiazide
- Trichlormethiazide
other: Chlorthalidone
- Metolazone
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Sodium, potassium, chloride |
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Antihypertensives: diuretics (C03)
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Sulfonamides
(and etacrynic acid) |
CA inhibitors (at PT) |
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Loop (Na-K-Cl at AL) |
- Furosemide#
- Bumetanide
- Etacrynic acid
- Etozoline
- Muzolimine
- Piretanide
- Tienilic acid
- Torasemide
|
|
Thiazides (Na-Cl at DCT,
Calcium-sparing) |
- Altizide
- Bendroflumethiazide
- Chlorothiazide
- Cyclopenthiazide
- Cyclothiazide
- Epitizide
- Hydrochlorothiazide#
- Hydroflumethiazide
- Mebutizide
- Methyclothiazide
- Polythiazide
- Trichlormethiazide
|
|
Thiazide-likes (primarily DCT) |
- Quinethazone
- Clopamide
- Chlortalidone
- Mefruside
- Clofenamide
- Metolazone
- Meticrane
- Xipamide
- Indapamide
- Clorexolone
- Fenquizone
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|
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Potassium-sparing (at CD) |
ESC blockers |
- Amiloride#
- Triamterene
- Benzamil
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Aldosterone antagonists |
- Spironolactone#
- Eplerenone
- Potassium canrenoate
- Canrenone
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Osmotic diuretics (PT, DL) |
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Vasopressin receptor inhibitors
(DCT and CD) |
- Vaptans: Conivaptan
- Mozavaptan
- Satavaptan
- Tolvaptan
- Others: Demeclocycline
- Lithium carbonate
|
|
Other |
- ethanol, isopropanol, 2M2B
- mercurial diuretic (Mersalyl, Meralluride)
- Theobromine
- Cicletanine
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|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
Index of the circulatory system
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Description |
- Anatomy
- Arteries
- head and neck
- arms
- chest
- abdomen
- legs
- Veins
- head and neck
- arms
- chest
- abdomen and pelvis
- legs
- Development
- Cells
- Physiology
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Disease |
- Congenital
- Neoplasms and cancer
- Lymphatic vessels
- Injury
- Vasculitis
- Other
- Symptoms and signs
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Treatment |
- Procedures
- Drugs
- beta blockers
- channel blockers
- diuretics
- nonsympatholytic vasodilatory antihypertensives
- peripheral vasodilators
- renin–angiotensin system
- sympatholytic antihypertensives
- vasoprotectives
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English Journal
- [A case of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) in which lomerizine hydrochloride was suggested to prevent recurrent stroke].
- Shimizu H1, Nagami S, Takahashi N.
- Rinshō shinkeigaku = Clinical neurology.Rinsho Shinkeigaku.2014;54(1):22-6.
- A 60-year-old man visited our hospital because of left hemiparesis in September 2006. Magnetic resonance imaging (MRI) revealed a high-intensity lesions in the right corona radiata on diffusion-weighted images and a high-intensity lesions in the basal ganglia and deep white matter on T2-weighted ima
- PMID 24429644
- Thiazide diuretics as chronic antihypertensive therapy in patients with severe renal disease--is there a role in the absence of diuresis?
- Chan CY1, Peterson EJ, Ng TM.
- The Annals of pharmacotherapy.Ann Pharmacother.2012 Nov;46(11):1554-8. doi: 10.1345/aph.1R212. Epub 2012 Nov 7.
- OBJECTIVE: To determine whether thiazides have a chronic antihypertensive effect, in the absence of diuresis, in patients with severe renal disease (creatinine clearance <30 mL/min) or in those receiving dialysis.DATA SOURCES: A search was performed in PubMed, CENTRAL, and International Pharmaceu
- PMID 23136355
- [Enantioselective determinination of R-warfarin/S-warfarin in human plasma using liquid chromatography-tandem mass spectrometry and its application in a drug-drug interaction study].
- Jin S1, Zhang YF, Chen XY, Liu K, Zhong DF.
- Yao xue xue bao = Acta pharmaceutica Sinica.Yao Xue Xue Bao.2012 Jan;47(1):105-9.
- To study the drug-drug interaction of morinidazole and warfarin and its application, a sensitive and rapid liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed for the determination of R-warfarin/S-warfarin in human plasma. In a random, two-period crossover study, 12 healt
- PMID 22493814
Japanese Journal
- KCl Inhibits Hypothalamic Activity to Attenuate Hypertension in DOCA-salt Rats : THE 13TH CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- SASAKI SUSUMU,TAKEDA KAZUO,TAKAHASHI HAKUO,YONEDA SEIICHI,OKAJIMA HIROSHI,IYODA ISAO,YOSHIMURA MANABU,IJICHI HAMAO
- Japanese circulation journal 48(11), 1251-1259, 1984-11-20
- … Pretreatment with methyclothiazide also attenuated the elevation in blood pressure but did not affect the responsiveness to hypothalamic stimulation; …
- NAID 110002578177
- Methyclothiazide attenuates salt-induced hypertension without affecting sympathetic responsiveness in Dahl rats
- A Double-Blind Controlled Study on the Antihypertensive Effectiveness of Uricosu-ric Diuretic FR 3068 in Essential Hypertension as Compared with Methyclothiazide
- 阿部 久雄,藤瀬 幸保,星川 弘紀,若林 央,飯村 攻,佐久間 昭
- 臨床薬理 11(3), 249-261, 1980
- … The antihypertensive effectiveness, influence on laboratory parameters and adverse reaction of FR 3068 (tienilic acid, FR), a new nonthiazide diuretic developed by Albert Rolland Co. of France with uricosuric properties, were evaluated by double-blind parallel group comparison with methyclothiazide (MCTZ).<BR>Placebo was initially administered for a period of at least 2 weeks. …
- NAID 130002048202
Related Links
- Before taking methyclothiazide, tell your doctor and pharmacist if you are allergic to methyclothiazide, sulfonamide medications, any other medications, or any of the ingredients in methyclothiazide tablets. Ask your ...
- methyclothiazide /meth·y·clo·thi·a·zide/ (meth″ĭ-klo-thi´ah-zīd) a thiazide diuretic used for treatment of hypertension and edema. methyclothiazide [məthī′klōthī′əzīd, meth′əklōthī′əzīd] a diuretic. indications It is prescribed in the ...
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