関: methoxyphenamine hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/04/14 03:18:22」(JST)

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Methoxyphenamine (trade names ASMI, Euspirol, Orthoxine, Ortodrinex, Proasma), also known as 2-methoxy-N-methylamphetamine (OMMA), is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator.^[1]

Chemistry

Methoxyphenamine was first synthesized at the Upjohn company by Woodruff and co-workers.^[2] A later synthesis by Heinzelman, from the same company, corrects the m.p. given for methoxyphenamine hydrochloride in the earlier paper, and describes an improved synthetic procedure, as well as resolution of the racemic methoxyphenamine.^[3]

References

^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.
^ E. H. Woodruff, J. P. Lambooy and W. E. Burt (1940). "Physiologically active amines. III. Secondary and tertiary β-phenylpropylamines and β-phenylisopropylamines." J. Am. Chem. Soc. 62 922-924.
^ R. V. Heinzelman (1953). "Physiologically active secondary amines. β-(o-Methoxyphenyl)-isopropyl-N-methylamine and related compounds." J. Am. Chem. Soc. 75 921-925.

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English Journal

In-line coupling of single-drop microextraction with capillary electrophoresis-mass spectrometry.

Kim J1, Choi K2, Chung DS3.
Analytical and bioanalytical chemistry.Anal Bioanal Chem.2015 Nov;407(29):8745-52. doi: 10.1007/s00216-015-9028-0. Epub 2015 Sep 24.
Single-drop microextraction (SDME) was in-line coupled with capillary electrophoresis-mass spectrometry to provide sample cleanup and enrichment simultaneously. Since there is no outlet vial in a conventional capillary electrophoresis-electrospray ionization-mass spectrometry (CE-ESI-MS) configurati
PMID 26403239

Comparison of zonal elution and nonlinear chromatography in determination of the interaction between seven drugs and immobilised β(2)-adrenoceptor.

Li Q1, Wang J1, Zheng YY2, Yang L1, Zhang Y1, Bian L1, Zheng J1, Li Z3, Zhao X4, Zhang Y5.
Journal of chromatography. A.J Chromatogr A.2015 Jul 3;1401:75-83. doi: 10.1016/j.chroma.2015.05.012. Epub 2015 May 14.
Zonal elution and nonlinear chromatography are two mainstream models for the determination of drug-protein interaction in affinity chromatography. This work intended to compare the results by zonal elution with that by nonlinear chromatography when it comes to the analysis of the interaction between
PMID 26002106

Time-course mass spectrometry imaging for depicting drug incorporation into hair.

Kamata T1, Shima N1, Sasaki K1, Matsuta S1, Takei S1, Katagi M1, Miki A1, Zaitsu K, Nakanishi T2, Sato T3, Suzuki K3, Tsuchihashi H3.
Analytical chemistry.Anal Chem.2015 Jun 2;87(11):5476-81. doi: 10.1021/acs.analchem.5b00971. Epub 2015 May 6.
In order to investigate the incorporation of drugs into hair, matrix-assisted laser desorption/ionization-time-of-flight tandem mass spectrometry (MS/MS) imaging was performed on the longitudinal sections of single scalp hair shafts sampled from volunteers after a single oral administration of metho
PMID 25919888

Japanese Journal

Induction of metamorphosis of pediveliger larvae of the mussel Mytilus galloprovincialis Lamarck, 1819 using neuroactive compounds, KCl, NH4Cl and organic solvents.

Yang Jin-Long,Satuito Cyril Glenn,Bao Wei-Yang,Kitamura Hitoshi
Biofouling 24(6), 461-470, 2008-08-12
… In 24-h exposure assays, alpha-methyldopa at 5 x 10(-5) M and methoxyphenamine at 5 x 10(-5)-10(-4) M induced 55-94% metamorphosis. …
NAID 120001779926

イムノアッセイを原理とする尿中覚せい剤の捜査現場予備試験法

宮沢正,荻野智,中島邦生 [他],南幸男
分析化学 45(8), 805-809, 1996-08-05
イムノアッセイを原理とした尿中覚せい剤の捜査現場用予備テストカード"Drug-of-Abuse One Step Test"を実際の事件に関連した尿資料のスクリーニングに適用するための諸条件を検討した.検出限界はメタンフェタミン用テストカード(MA用)は1μg/ml, アンフェタミン用テストカード(AM用)は2μg/mlであった.両テストカードの交差反応性について7種の覚せい剤類縁化合物を用いて調 …
NAID 110002907087

Hair Analysis for Drugs of Abuse. X. Effect of Physicochemical Properties of Drugs on the Incorporation Rates into Hair

中原雄二,高橋一徳,木倉瑠理
Biological & pharmaceutical bulletin 18(9), 1223-1227, 1995-09-15
… amphetamine, methamphetamine, p-hydroxyamphetamine, p-hydroxymethamphetamine, cocaine, benzoylecgonine, ecgonine methyl ester, morphine, 6-acetylmorphine, phencyclidine, 1-(1-phenyl)-piperidinyl-cyclohexanol, methylenedioxyamphetamine, methylenedioxymethamphetamine, methoxyphenamine, O-desmethyl methoxyphenamine, benzphetamine, norbenzphetamine, deprenyl, lysergic acid diethylamide (LSD) and 11-nortetrahydrocannabinol-9-carboxylic acid (THCA). …
NAID 110003641026

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Methoxyphenamine
Systematic (IUPAC) name
	1-(2-methoxyphenyl)-N-methylpropan-2-amine
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ Prescription only
Routes	Oral
Identifiers
CAS number	93-30-1
ATC code	R03CB02
PubChem	CID 4117
ChemSpider	3974
UNII	J3Z5SRI26Z
Chemical data
Formula	C11H17NO
Mol. mass	179.26 g/mol
	SMILES CC(CC1=CC=CC=C1OC)NC;
	InChI InChI=1S/C11H17NO/c1-9(12-2)8-10-6-4-5-7-11(10)13-3/h4-7,9,12H,8H2,1-3H3; Key:OEHAYUOVELTAPG-UHFFFAOYSA-N ;