関: methoxamine hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/19 18:26:32」(JST)

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Methoxamine is an α₁-adrenergic receptor agonist,^[1] similar in structure to phenylephrine and 2,5-DMA. It was developed by Burroughs-Wellcome in the 1940s.^[2] The drug induces vasoconstriction of skin and splanchnic blood vessels, thereby increasing peripheral vascular resistance and raising mean arterial blood pressure. Because of its hypertensive effects, it may evoke a compensatory reflex bradycardia via the baroreceptors.

References

^ Pazdernik, Thomas L.; Kerecsen, Laszlo (2007) [2003]. "5". In Goljan, Edward F. Pharmacology (Paperback)|format= requires |url= (help). Rapid Review (Second ed.). Philadelphia, PA: Mosby-Elsevier. p. 39. ISBN 978-0-323-04550-6. |accessdate= requires |url= (help)
^ US Patent 2359707 - DIMETHOXYPHENYL beta-HYDROXY ISOPROPYLAMINE

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English Journal

Endogenous oestrogens do not regulate endothelial nitric oxide production in early postnatal rats.

Sofronova SI1, Gaynullina DK2, Martyanov AA3, Tarasova OS3.
European journal of pharmacology.Eur J Pharmacol.2015 Sep 28. pii: S0014-2999(15)30270-3. doi: 10.1016/j.ejphar.2015.09.037. [Epub ahead of print]
Previously we showed that endothelium of 1-2-weeks old rats exerts an anticontractile effect due to spontaneous NO production which correlates with a higher eNOS expression level compared to adult rats. Oestrogens are powerful regulators of eNOS expression and activity in arterial endothelium. This
PMID 26415981

Identification of the cold receptor TRPM8 in the nasal mucosa.

Liu SC1, Lu HH, Cheng LH, Chu YH, Lee FP, Wu CC, Wang HW.
American journal of rhinology & allergy.Am J Rhinol Allergy.2015 Jul-Aug;29(4):e112-6. doi: 10.2500/ajra.2015.29.4202.
BACKGROUND: The transient receptor potential channel melastatin 8 (TRPM8) has been proposed to be a cold receptor. However, its distribution and physiologic role in the nose is not yet fully explored.OBJECTIVE: We investigated the expression of TRPM8 in human nasal mucosa and its function when using
PMID 26163239

Pharmacological evidence that histamine H3 receptors inhibit the vasodepressor responses by selective stimulation of the rat perivascular sensory CGRPergic outflow.

Manrique-Maldonado G1, Altamirano-Espinoza AH2, Marichal-Cancino BA3, Rivera-Mancilla E4, Avilés-Rosas V5, Villalón CM6.
European journal of pharmacology.Eur J Pharmacol.2015 May 5;754:25-31. doi: 10.1016/j.ejphar.2015.02.017. Epub 2015 Feb 19.
This study has investigated whether pharmacological activation of Gi/o coupled histamine H3/H4 receptors inhibits the rat vasodepressor sensory outflow. For this purpose, 100 male Wistar rats were pithed, artificially ventilated and pretreated (i.v.) with: 25mg/kg gallamine, 2mg/kg/min hexamethonium
PMID 25704614

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拡張検索	「methoxamine hydrochloride」

「methoxamine hydrochloride」

Methoxamine
Systematic (IUPAC) name
	2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Registry Number	390-28-3
ATC code	C01CA10
PubChem	CID: 6082
IUPHAR/BPS	483
DrugBank	DB00723
ChemSpider	5857
UNII	HUQ1KC1YLI
KEGG	D08201
ChEMBL	CHEMBL524
Chemical data
Formula	C11H17NO3
Molecular mass	211.258
	SMILES O(c1ccc(OC)cc1C(O)C(N)C)C ;
	InChI InChI=1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3 ; Key:WJAJPNHVVFWKKL-UHFFFAOYSA-N ;
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関: methoxamine

[1] Pazdernik, Thomas L.; Kerecsen, Laszlo (2007) [2003]. "5". In Goljan, Edward F. Pharmacology (Paperback)|format= requires |url= (help). Rapid Review (Second ed.). Philadelphia, PA: Mosby-Elsevier. p. 39. ISBN 978-0-323-04550-6. |accessdate= requires |url= (help)

[2] US Patent 2359707 - DIMETHOXYPHENYL beta-HYDROXY ISOPROPYLAMINE

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methoxamine