WordNet

any specific behavior; "they avoided all recreational activity"
(chemistry) the capacity of a substance to take part in a chemical reaction; "catalytic activity"
an enzyme that catalyses the biochemical reduction of some specified substance

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Structure Guided Chemical Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome b5 Reductase 3 That Increase Nitric Oxide Bioavailability.

Rahaman MM1, Reinders FG2, Koes D2, Nguyen AT1, Mutchler SM3, Sparacino-Watkins C1, Alvarez RA4, Miller MP1, Cheng D5, Chen BB6, Jackson EK5, Camacho CJ2, Straub AC7.
The Journal of biological chemistry.J Biol Chem.2015 Jul 3;290(27):16861-72. doi: 10.1074/jbc.M114.629964. Epub 2015 May 22.
NADH cytochrome b5 reductase 3 (CYB5R3) is critical for reductive reactions such as fatty acid elongation, cholesterol biosynthesis, drug metabolism, and methemoglobin reduction. Although the physiological and metabolic importance of CYB5R3 has been established in hepatocytes and erythrocytes, emerg
PMID 26001785

Methemoglobin reduction mediated by D-amino acid dehydrogenase in Propsilocerus akamusi (Tokunaga) larvae.

Kobori H1, Tanigawa M1, Maeda S1, Hori H2, Yubisui T3, Nagata Y4.
Journal of insect physiology.J Insect Physiol.2015 Jun;77:33-8. doi: 10.1016/j.jinsphys.2015.04.002. Epub 2015 Apr 18.
A methemoglobin (metHb) reduction system is required for aerobic respiration. In humans, Fe(III)-heme-bearing metHb (the oxidized form of hemoglobin), which cannot bind oxygen, is converted to Fe(II)-heme-bearing oxyhemoglobin (oxyHb, the reduced form), which can bind oxygen, in a system comprising
PMID 25896287

Genetic variation in CYB5R3 is associated with methemoglobin levels in preterm infants receiving nitric oxide therapy.

Fuller TD1, Spracklen CN2, Ryckman KK2, Knake LA1, Busch TD1, Momany AM1, Murray JC1, Dagle JM1.
Pediatric research.Pediatr Res.2015 Mar;77(3):472-6. doi: 10.1038/pr.2014.206. Epub 2014 Dec 18.
BACKGROUND: In recent years, increasing numbers of preterm infants have been exposed to inhaled nitric oxide (iNO). This population has decreased methemoglobin (MetHb) reductase activity in their erythrocytes, which may increase the risk of MetHb toxicity. We sought to determine if genetic factors a
PMID 25521918

Genetic and Biochemical Studies of Hereditary Methemoglobinemia (NADH-Cytochrome b5 Reductase Deficiency

Methemoglobin Formation and Reduction in Canine Erythrocytes Characterized by Inherited High Na+, K+-ATPase Activity with Normal and High Glutathione Concentrations.