methemalbumin

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/02 12:36:34」(JST)

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Methemalbumin is an albumin complex consisting of albumin and heme.^[1]^[2]

This complex gives brown color to plasma and occurs in hemolytic and hemorrhagic disorders.

Its presence in plasma is used to differentiate between hemorrhagic and edematous pancreatitis.

The Schumm test is used to differentiate intravascular haemolysis from extravascular haemolysis, as in haemolytic anaemias. A positive result is indicative of intravascular haemolysis.

References

^ Methemalbumin at the US National Library of Medicine Medical Subject Headings (MeSH)
^ Myara I, Myara A, Drupt F, Moatti N, Trivin F (September 1988). "Methemalbumin interference in various biochemical assays of plasma". Clin. Chem. 34 (9): 1919–20. PMID 3416455.

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1. 黄疸または無症候性高ビリルビン血症の分類および原因 classification and causes of jaundice or asymptomatic hyperbilirubinemia

English Journal

Tyrosine residues play an important role in heme detoxification by serum albumin.

Huang Y1, Shuai Y1, Li H1, Gao Z2.
Biochimica et biophysica acta.Biochim Biophys Acta.2014 Mar;1840(3):970-6. doi: 10.1016/j.bbagen.2013.11.011. Epub 2013 Nov 16.
BACKGROUND: Serum albumin binds avidly to heme to form heme-serum albumin complex, also called methemalbumin, and this binding is thought to protect against the potentially toxic effects of heme. However, the mechanism of detoxification has not been fully elucidated.METHODS: SDS-PAGE and Western blo
PMID 24252277

Evidence of mutualism between two periodontal pathogens: co-operative haem acquisition by the HmuY haemophore of Porphyromonas gingivalis and the cysteine protease interpain A (InpA) of Prevotella intermedia.

Byrne DP1, Potempa J, Olczak T, Smalley JW.
Molecular oral microbiology.Mol Oral Microbiol.2013 Jun;28(3):219-29. doi: 10.1111/omi.12018. Epub 2013 Jan 22.
Haem (iron protoporphyrin IX) is both an essential growth factor and a virulence regulator of the periodontal pathogens Porphyromonas gingivalis and Prevotella intermedia, which acquire it through the proteolytic degradation of haemoglobin and other haem-carrying plasma proteins. The haem-binding li
PMID 23336115

Intracellular accumulation of bilirubin as a defense mechanism against increased oxidative stress.

Zelenka J1, Muchova L, Zelenkova M, Vanova K, Vreman HJ, Wong RJ, Vitek L.
Biochimie.Biochimie.2012 Aug;94(8):1821-7. doi: 10.1016/j.biochi.2012.04.026. Epub 2012 May 10.
Antioxidant, anti-inflammatory and anti-atherogenic effects have been associated with elevations of unconjugated bilirubin (UCB) in serum and with the induction of heme oxygenase-1 (HO-1), the rate-limiting enzyme in UCB synthesis. The aim of this study was to investigate the intracellular metabolis
PMID 22580386