WordNet
- create by mixing or combining
- (chemistry) a substance formed by chemical union of two or more elements or ingredients in definite proportion by weight (同)chemical_compound
- put or add together; "combine resources" (同)combine
- an enclosure of residences and other building (especially in the Orient)
- a whole formed by a union of two or more elements or parts
- combine so as to form a whole; mix; "compound the ingredients" (同)combine
- calculate principal and interest
- composed of more than one part; "compound leaves are composed of several lobes; "compound flower heads"
- consisting of two or more substances or ingredients or elements or parts; "soap is a compound substance"; "housetop is a compound word"; "a blackberry is a compound fruit"
- parasympathomimetic drug (trademark Mecholyl) that stimulates secretions and smooth muscle activity (同)Mecholyl
- combined into or constituting a chemical compound
PrepTutorEJDIC
- (…になるように)〈要素・成分など〉'を'混ぜ合わせる《+『名』+『into』+『名』》;(…から)〈薬など〉'を'調合する,混ぜ合わせて作る《+『名』+『from』(『of』)+『名』》 / 《しばしば受動態で》〈めんどうな事・損害など〉'を'もっとひどくする / 〈利子〉'を'複利で計算する / (…と)話し合いをつける,妥協する《+『with』+『名』》 / 複合の,合成の / 『合成物』,混合物,調合物;化合物 / 複合語,合成語(classroom, heart-to-heartなどをいう)
- (異民族の家屋・商館などがある)囲み地区,構内
UpToDate Contents
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English Journal
- Bronchodilatory and anti-inflammatory effects of ASM-024, a nicotinic receptor ligand, developed for the treatment of asthma.
- Assayag EI1, Beaulieu MJ2, Cormier Y1.Author information 1Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, QC, Canada ; Asmacure Ltée, Québec, QC, Canada.2Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, QC, Canada.AbstractConventional asthma and COPD treatments include the use of bronchodilators, mainly β2-adrenergic agonists, muscarinic receptor antagonists and corticosteroids or leukotriene antagonists as anti-inflammatory agents. These active drugs are administered either separately or given as a fixed-dose combination medication into a single inhaler. ASM-024, a homopiperazinium compound, derived from the structural modification of diphenylmethylpiperazinium (DMPP), has been developed to offer an alternative mechanism of action that could provide symptomatic control through combined anti-inflammatory and bronchodilator properties in a single entity. A dose-dependent inhibition of cellular inflammation in bronchoalveolar lavage fluid was observed in ovalbumin-sensitized mice, subsequently treated for 3 days by nose-only exposure with aerosolized ASM-024 at doses up to 3.8 mg/kg (ED50 = 0.03 mg/kg). The methacholine ED250 values indicated that airway hyperresponsivenness (AHR) to methacholine decreased following ASM-024 administration by inhalation at a dose of 1.5 mg/kg, with a value of 0.145 ± 0.032 mg/kg for ASM 024-treated group as compared to 0.088 ± 0.023 mg/kg for untreated mice. In in vitro isometric studies, ASM-024 elicited dose-dependent relaxation of isolated mouse tracheal, human, and dog bronchial preparations contracted with methacholine and guinea pig tracheas contracted with histamine. ASM-024 showed also a dose and time dependant protective effect on methacholine-induced contraction. Overall, with its combined anti-inflammatory, bronchodilating and bronchoprotective properties, ASM-024 may represent a new class of drugs with a novel pharmacological approach that could prove useful for the chronic maintenance treatment of asthma and, possibly, COPD.
- PloS one.PLoS One.2014 Jan 22;9(1):e86091. doi: 10.1371/journal.pone.0086091. eCollection 2014.
- Conventional asthma and COPD treatments include the use of bronchodilators, mainly β2-adrenergic agonists, muscarinic receptor antagonists and corticosteroids or leukotriene antagonists as anti-inflammatory agents. These active drugs are administered either separately or given as a fixed-dose combi
- PMID 24465890
- Mast cell mediators cause early allergic bronchoconstriction in guinea-pigs in vivo: a model of relevance to asthma.
- Riley JP1, Fuchs B, Sjöberg L, Nilsson GP, Karlsson L, Dahlén SE, Rao NL, Adner M.Author information 1Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, USA.AbstractOne feature of allergic asthma, the EAR (early allergic reaction), is not present in the commonly used mouse models. We therefore investigated the mediators involved in EAR in a guinea-pig in vivo model of allergic airway inflammation. Animals were sensitized using a single OVA (ovalbumin)/alum injection and challenged with aerosolized OVA on day 14. On day 15, airway resistance was assessed after challenge with OVA or MCh (methacholine) using the forced oscillation technique, and lung tissue was prepared for histology. The contribution of mast cell mediators was investigated using inhibitors of the main mast cell mediators [histamine (pyrilamine) and CysLTs (cysteinyl-leukotrienes) (montelukast) and prostanoids (indomethacin)]. OVA-sensitized and challenged animals demonstrated AHR (airway hyper-responsiveness) to MCh, and lung tissue eosinophilic inflammation. Antigen challenge induced a strong EAR in the sensitized animals. Treatment with a single compound, or indomethacin together with pyrilamine or montelukast, did not reduce the antigen-induced airway resistance. In contrast, dual treatment with pyrilamine together with montelukast, or triple inhibitor treatment, attenuated approximately 70% of the EAR. We conclude that, as in humans, the guinea-pig allergic inflammation model exhibits both EAR and AHR, supporting its suitability for in vivo identification of mast cell mediators that contribute to the development of asthma. Moreover, the known mast cell mediators histamine and leukotrienes were major contributors of the EAR. The data also lend further support to the concept that combination therapy with selective inhibitors of key mediators could improve asthma management.
- Clinical science (London, England : 1979).Clin Sci (Lond).2013 Dec;125(11):533-42. doi: 10.1042/CS20130092.
- One feature of allergic asthma, the EAR (early allergic reaction), is not present in the commonly used mouse models. We therefore investigated the mediators involved in EAR in a guinea-pig in vivo model of allergic airway inflammation. Animals were sensitized using a single OVA (ovalbumin)/alum inje
- PMID 23799245
- Inhibition of chlorine-induced pulmonary inflammation and edema by mometasone and budesonide.
- Chen J1, Mo Y, Schlueter CF, Hoyle GW.Author information 1Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA.AbstractChlorine gas is a widely used industrial compound that is highly toxic by inhalation and is considered a chemical threat agent. Inhalation of high levels of chlorine results in acute lung injury characterized by pneumonitis, pulmonary edema, and decrements in lung function. Because inflammatory processes can promote damage in the injured lung, anti-inflammatory therapy may be of potential benefit for treating chemical-induced acute lung injury. We previously developed a chlorine inhalation model in which mice develop epithelial injury, neutrophilic inflammation, pulmonary edema, and impaired pulmonary function. This model was used to evaluate nine corticosteroids for the ability to inhibit chlorine-induced neutrophilic inflammation. Two of the most potent corticosteroids in this assay, mometasone and budesonide, were investigated further. Mometasone or budesonide administered intraperitoneally 1h after chlorine inhalation caused a dose-dependent inhibition of neutrophil influx in lung tissue sections and in the number of neutrophils in lung lavage fluid. Budesonide, but not mometasone, reduced the levels of the neutrophil attractant CXCL1 in lavage fluid 6h after exposure. Mometasone or budesonide also significantly inhibited pulmonary edema assessed 1 day after chlorine exposure. Chlorine inhalation resulted in airway hyperreactivity to inhaled methacholine, but neither mometasone nor budesonide significantly affected this parameter. The results suggest that mometasone and budesonide may represent potential treatments for chemical-induced lung injury.
- Toxicology and applied pharmacology.Toxicol Appl Pharmacol.2013 Oct 15;272(2):408-13. doi: 10.1016/j.taap.2013.06.009. Epub 2013 Jun 22.
- Chlorine gas is a widely used industrial compound that is highly toxic by inhalation and is considered a chemical threat agent. Inhalation of high levels of chlorine results in acute lung injury characterized by pneumonitis, pulmonary edema, and decrements in lung function. Because inflammatory proc
- PMID 23800689
Japanese Journal
- Effects of Muscarinic Receptor Antagonists With or Without M_2 Antagonist Activity on Cholinergic Reflex Bronchoconstriction in Ovalbumin-Sensitized and-Challenged Mice
- HIROSE Hiroyasu,JIANG Jian,NISHIKIBE Masaru
- Journal of pharmacological sciences 92(3), 209-217, 2003-07-01
- … To investigate whether the inhibition of muscarinic M2 receptors results in the enhancement of reflex bronchoconstriction under airway hyperresponsiveness, we evaluated the effects of muscarinic antagonists with or without M2 antagonist activity on methacholine (MCh)- and SO2-induced airway responses in ovalbumin (OVA)-sensitized and -challenged mice. … 0.3 mg/ml, inhalation) and Compound A (0.1 – … On the other hand, Compound A (0.03 – …
- NAID 130000073648
- Imidazoline Receptor Contributes to Ion and Water Transport across the Intestine of the Eel Acclimated to Sea Water(Physiology)
- Ando Masaaki,Kim Hung Tae,Takase Ichiro,Kawahara Akira
- Zoological science 17(3), 307-312, 2000-04-10
- … Guanabenz, an I_2-imidazoline-related compound with high affinity for intestinal membrane of the eel (Kim et al., 1998), enhanced the transepithelial potential difference (PD) and short-circuit current (Isc) from serosa to mucosa after pretreatment with isobutylmethylxanthine (IBMX), serotonin (5-HT) and methacholine (MCh). …
- NAID 110003371136
- 本間 正明,田村 弦,谷口 幸彦,滝島 任
- アレルギー 40(12), 1470-1476, 1991-12-30
- 注射金製剤に比べ副作用の少ない経口の金製剤であるオーラノフィンは, すでに慢性関節リウマチに対しては臨床的に使用されており, また喘息患者への有用性が確立されつつある. そこで喘息患者25症例にオーラノフィン(6mg/day)またはプラセボ錠を二重盲検法で12週間連続して投与し, 投与開始前と6週後, 12週後にメサコリン吸入誘発試験, 肺機能検査, ならびに血中金濃度を測定し, その効果を検討し …
- NAID 110002417479
Related Links
- methacholine | C8H18NO2+ | CID 1993 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. NIH NLM ...
- Thesaurus Antonyms Related Words Synonyms Legend: Switch to new thesaurus Noun 1. methacholine - parasympathomimetic drug (trademark Mecholyl) that stimulates secretions and smooth muscle activity Mecholyl ...
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- 関
- combination、compositus、mixture