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an acid tartrate; a hydrogen tartrate

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/16 10:37:27」(JST)

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Metaraminol (INN; trade names Aramine, Metaramin, and Pressonex), also known as metaradrine, a stereoisomer of meta-hydroxynorephedrine (3,β-dihydroxyamphetamine), is a potent sympathomimetic amine used in the prevention and treatment of hypotension, particularly as a complication of anesthesia. It is an α₁-adrenergic receptor agonist with some β effect.^[1]

Metaraminol is also used in the treatment of priapism. Although not approved for this use, it appears to be effective.^[2]^[3]^[4]

References

^ Kee VR. Hemodynamic pharmacology of intravenous vasopressors. Crit Care Nurse. 2003 Aug;23(4):79-82. PMID 12961786
^ McDonald M, Santucci R (2004). "Successful management of stuttering priapism using home self-injections of the alpha-agonist metaraminol.". Int Braz J Urol 30 (2): 121–2. doi:10.1590/S1677-55382004000200007. PMID 15703094.
^ Koga S, Shiraishi K, Saito Y (1990). "Post-traumatic priapism treated with metaraminol bitartrate: case report.". J Trauma 30 (12): 1591–3. doi:10.1097/00005373-199012000-00029. PMID 2258979.
^ Block T, Sturm W, Ernst G, Staehler G, Schmiedt E (1988). "[Metaraminol in therapy of various forms of priapism]". Urologe A 27 (4): 225–9. PMID 3140463.

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2. シスチン蓄積症 cystinosis
3. 妊娠中の異食症 pica in pregnancy

English Journal

Propofol for adult procedural sedation in a UK emergency department: safety profile in 1008 cases.

Newstead B1, Bradburn S, Appelboam A, Reuben A, Harris A, Hudson A, Jones L, McLauchlan C, Riou P, Jadav M, Lloyd G.Author information 1Emergency Department, Royal Devon & Exeter NHS Foundation Trust, Barrack Road, Exeter EX2 5DW, UK.AbstractBACKGROUND: Concerns exist regarding the safe use of propofol by Emergency Physicians for procedural sedation. The World SIVA International Sedation Task Force has recently created an adverse event tool, in an effort to standardize reporting. We present a safety analysis of our use of propofol using this tool.
British journal of anaesthesia.Br J Anaesth.2013 Oct;111(4):651-5. doi: 10.1093/bja/aet168. Epub 2013 May 9.
BACKGROUND: Concerns exist regarding the safe use of propofol by Emergency Physicians for procedural sedation. The World SIVA International Sedation Task Force has recently created an adverse event tool, in an effort to standardize reporting. We present a safety analysis of our use of propofol using
PMID 23661404

Use of vasopressors in Takotsubo cardiomyopathy: a cautionary tale.

Redmond M, Knapp C, Salim M, Shanbhag S, Jaumdally R.
British journal of anaesthesia.Br J Anaesth.2013 Mar;110(3):487-8. doi: 10.1093/bja/aes586.
PMID 23404978

A comparison of three vasopressors for tight control of maternal blood pressure during cesarean section under spinal anesthesia: Effect on maternal and fetal outcome.

Bhardwaj N1, Jain K, Arora S, Bharti N.Author information 1Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research, Chandigarh, India.AbstractPURPOSE: Maintaining systolic blood pressure (SBP) at 100% of baseline is best for fetal and maternal outcome. We hypothesized that irrespective of the vasopressor used, maintaining SBP at 100% of baseline with phenylephrine (P), metaraminol (M), or ephedrine (E) will produce the best fetal pH after cesarean section (LSCS) under subarachnoid block (SAB).
Journal of anaesthesiology, clinical pharmacology.J Anaesthesiol Clin Pharmacol.2013 Jan;29(1):26-31. doi: 10.4103/0970-9185.105789.
PURPOSE: Maintaining systolic blood pressure (SBP) at 100% of baseline is best for fetal and maternal outcome. We hypothesized that irrespective of the vasopressor used, maintaining SBP at 100% of baseline with phenylephrine (P), metaraminol (M), or ephedrine (E) will produce the best fetal pH after
PMID 23492921

Japanese Journal

Pharmacokinetic study of three cardiovascular drugs by high-performance liquid chromatography using pre-column derivatization with 9,10-anthraquinone-2-sulfonyl chloride

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 858(1), 42-48, 2007-10-15
NAID 10025809878

Post-traumatic priapism treated with metaraminol bitartrate: Case report.

J. Trauma 30, 1591-1593, 1990
NAID 30009384444

ウサギ肺動脈, 大動脈切片標本におけるプロスタグランディンE1, E2の作用について

日本胸部疾患学会雑誌 16(7), 490-494, 1978
NAID 130003674420

「酒石酸水素メタラミノール」

Metaraminol
Systematic (IUPAC) name
	(1R,2S)-3-[-2-amino-1-hydroxy-propyl]phenol
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy; category	AU: C; US: C (Risk not ruled out); ;
Routes of; administration	Intravenous
Legal status
Legal status	UK: POM (Prescription only);
Pharmacokinetic data
Bioavailability	n/a
Protein binding	~45%
Metabolism	Hepatic
Identifiers
CAS Number	54-49-9 ; 33402-03-8 (bitartrate)
ATC code	C01CA09 (WHO)
PubChem	CID 5906
IUPHAR/BPS	7229
DrugBank	DB00610
ChemSpider	5695
UNII	818U2PZ2EH
KEGG	D08192
ChEBI	CHEBI:6794
ChEMBL	CHEMBL1201319
Chemical data
Formula	C9H13NO2
Molar mass	167.205 g/mol
	SMILES O[C@H](c1cc(O)ccc1)[C@@H](N)C ;
	InChI InChI=1S/C9H13NO2/c1-6(10)9(12)7-3-2-4-8(11)5-7/h2-6,9,11-12H,10H2,1H3/t6-,9-/m0/s1 ; Key:WXFIGDLSSYIKKV-RCOVLWMOSA-N ;
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　　[★]

英: metaraminol bitartrate
関: メタラミノール

[1] Kee VR. Hemodynamic pharmacology of intravenous vasopressors. Crit Care Nurse. 2003 Aug;23(4):79-82. PMID 12961786

[McDonald-2] McDonald M, Santucci R (2004). "Successful management of stuttering priapism using home self-injections of the alpha-agonist metaraminol.". Int Braz J Urol 30 (2): 121–2. doi:10.1590/S1677-55382004000200007. PMID 15703094.

[Koga-3] Koga S, Shiraishi K, Saito Y (1990). "Post-traumatic priapism treated with metaraminol bitartrate: case report.". J Trauma 30 (12): 1591–3. doi:10.1097/00005373-199012000-00029. PMID 2258979.

[Block-4] Block T, Sturm W, Ernst G, Staehler G, Schmiedt E (1988). "[Metaraminol in therapy of various forms of priapism]". Urologe A 27 (4): 225–9. PMID 3140463.

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metaraminol bitartrate