後腎芽組織
WordNet
- a mass of undifferentiated cells from which an organ or body part develops
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/05/25 18:49:50」(JST)
[Wiki en表示]
Metanephrogenic blastema |
Latin |
blastema metanephrogenicum |
Carnegie stage |
14 |
Days |
35 |
Precursor |
Wolffian duct |
Gives rise to |
nephron (Bowman's capsule, connecting tubule, distal convoluted tubule, glomerulus, loop of Henle, proximal convoluted tubule), but not collecting duct |
Code |
TE E5.6.3.2.0.0.1 |
The metanephrogenic blastema or metanephric blastema (or metanephric mesenchyme, or metanephric mesoderm) is one of the two embryological structures that give rise to the kidney (the other is the ureteric bud.)
The metanephric blastema mostly develops into nephrons, but can also form parts of the collecting duct system.
The system of tissue induction between the ureteric bud and the metanephric blastema is a reciprocal control system. GDNF, gonadal derived neurotrophic factor, is produced by the metanephric blastema and is essential in binding to the Ret receptor on the ureteric bud, which bifurcates and coalesces as a result to form the renal pelvis, major and minor calyces and collecting ducts. Mutations in the EYA1 gene, which is a GDNF transcription factor, lead to the renal abnormalities of BOR syndrome (branchio-oto-renal syndrome).
See also
- Mesenchyme
- Metanephros
- Blastema
- Kidney development
External links
- Swiss embryology (from UL, UB, and UF) turinary/urinhaute01
- genital-017a — Embryo Images at University of North Carolina
- Diagram at mcgill.ca 1
- Diagram at mcgill.ca 2
- Qiao J, Cohen D, Herzlinger D (1995). "The metanephric blastema differentiates into collecting system and nephron epithelia in vitro.". Development 121 (10): 3207–14. PMID 7588055.
Development of the urinary and reproductive systems (GA 11.1204, TE E5.6-7)
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Common |
- Mesoderm → Intermediate mesoderm
- Mesoderm → Lateral plate mesoderm ("LPM")
- Endoderm → Cloaca → Urogenital sinus ("US")
- Endoderm+Ectoderm → Cloacal membrane
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Urinary system
development |
- Nephrogenic cord → Kidney
- Mesonephros (Mesonephric tubules)
- Mesonephric duct → Ureteric bud + Metanephrogenic blastema
- US → Urinary bladder + Urethra + Primary urethral groove + Urachus
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Reproductive system
development |
Internal |
- Gonadal ridge → Indifferent gonad → Gonadal cord (Cortical cords, Testis cords)
- Pronephric duct → Mesonephric (Wolffian) duct + Paramesonephric (Müllerian) duct (Vaginal plate)
- Urogenital sinus → Prostate or Skene's gland
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External |
- LPM → Genital tubercle → Labioscrotal swelling → Scrotum or Labia majora
- LPM → Genital tubercle → Primordial phallus → Penis or Clitoris
- Peritoneum → Processus vaginalis or Canal of Nuck
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See also |
- List of homologues of the human reproductive system
- Prenatal development
- Mammalian embryogenesis
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noco/acba/cong/tumr, sysi/epon, urte
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proc/itvp, drug (G4B), blte, urte
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noco/cong/npls, sysi/epon
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proc/asst, drug (G1/G2B/G3CD)
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noco/cong/tumr, sysi/epon
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UpToDate Contents
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English Journal
- Laparoscopic partial nephrectomy for renal cell carcinoma in a horseshoe kidney.
- Benidir T1, Coelho de Castilho TJ2, Cherubini GR3, de Almeida Luz M4.
- Canadian Urological Association journal = Journal de l'Association des urologues du Canada.Can Urol Assoc J.2014 Nov;8(11-12):E918-20. doi: 10.5489/cuaj.2289.
- Horseshoe kidney has an incidence rate ranging from 1 in 400 to 1 in 1000, with a 2:1 ratio in men. It also has a predilection for chromosomal aneuploidies. From a pathophysiology standpoint, this anomaly occurs during the second to sixth week of gestation when the inferior portion of the metanephri
- PMID 25553168
- Src tyrosine kinase mediates platelet-derived growth factor BB-induced and redox-dependent migration in metanephric mesenchymal cells.
- Wagner B1, Gorin Y.
- American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2014 Jan 1;306(1):F85-97. doi: 10.1152/ajprenal.00371.2013. Epub 2013 Nov 6.
- The adult kidney is derived from the interaction between the metanephric blastema and the ureteric bud. Platelet-derived growth factor (PDGF) receptor β is essential for the development of the mature glomerular tuft, as mice deficient for this receptor lack mesangial cells. This study investigated
- PMID 24197068
- Renal development: a complex process dependent on inductive interaction.
- Upadhyay KK, Silverstein DM1.
- Current pediatric reviews.Curr Pediatr Rev.2014;10(2):107-14.
- Renal development begins in-utero and continues throughout childhood. Almost one-third of all developmental anomalies include structural or functional abnormalities of the urinary tract. There are three main phases of in-utero renal development: Pronephros, Mesonephros and Metanephros. Within three
- PMID 25088264
Japanese Journal
- Immunohistochemical Characterization of a Renal Nephroblastoma in a Trp53-mutant and Prolyl Isomerase 1-deficient Mouse
- Castiglioni Vittoria,De Maglie Marcella,Queliti Roberta,Rustighi Alessandra,Del Sal Giannino,Radaelli Enrico
- Journal of Toxicologic Pathology 26(4), 423-427, 2013
- … A nephroblastoma is a tumor arising from metanephric blastema occurring in childhood. …
- NAID 130003382458
- Thy-1 Expressing Mesenchymal Cells in Rat Nephrogenesis in Correlation with Cells Immunoreactive for .ALPHA.-Smooth Muscle Actin and Vimentin
- Yuasa Takahiro,Izawa Takeshi,Kuwamura Mitsuru [他],Yamate Jyoji
- Journal of Toxicologic Pathology 23(1), 1-10, 2010
- … Through the epithelial-mesenchymal transition (EMT), injured renal epithelial cells undergo regression to the metanephric mesenchymal phenotype and then acquire a myofibroblastic nature (expressing α-smooth muscle actin; … Because the metanephric blastema differentiates into mesenchymal and renal epithelial cells, we investigated Thy-1 immunoexpression during nephrogenesis in F344 rats in correlation with vimentin and α-SMA expressions. …
- NAID 130000262636
- 佐藤 幸男,Satow Yukio,サトウ ユキオ
- 広島文化女子短期大学紀要 (31), 9-18, 1998
- … Especially, the metanephros, metanephric blastema, nephrogenic zone of the cortex and blood-urine barrier which consists of glomerulus, capillary vessel, basement membrane, podocyte and mesangium cells are observed and then physiological significance of the kidney are also discussed. …
- NAID 120005261021
Related Links
- metanephric blastema, a mass of intermediate mesodermal cells around the distal end of the ureteric bud that gives rise to nephrons in the permanent kidney. Also called metanephric cap, metanephric mass. met·a·neph·ric blas·te ...
- metanephric blastema, a mass of intermediate mesodermal cells around the distal end of the ureteric bud that gives rise to nephrons in the permanent kidney. Also called metanephric cap, metanephric mass. met·a·neph·ric blas·te ...
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- 関
- metanephros