metabolic disturbance

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/02/25 13:10:08」(JST)

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英文文献

  • Sex differences in rates of obesity in bipolar disorder: postulated mechanisms.
  • Baskaran A, Cha DS, Powell AM, Jalil D, McIntyre RS.Author information Centre for Neuroscience Studies, Queen's University, Kingston, Canada; Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada.AbstractOBJECTIVE: The increased standardized mortality ratio (SMR) from cardiovascular disease (CVD) in women with bipolar disorder (BD), relative to men with BD and individuals of both sexes in the general population, provides the impetus to identify factors that contribute to the differential association of obesity with BD in women.
  • Bipolar disorders.Bipolar Disord.2014 Feb;16(1):83-92. doi: 10.1111/bdi.12141. Epub 2013 Oct 29.
  • OBJECTIVE: The increased standardized mortality ratio (SMR) from cardiovascular disease (CVD) in women with bipolar disorder (BD), relative to men with BD and individuals of both sexes in the general population, provides the impetus to identify factors that contribute to the differential association
  • PMID 24467470
  • Deregulation of Pancreas-Specific Oxidoreductin ERO1β in the Pathogenesis of Diabetes Mellitus.
  • Awazawa M, Futami T, Sakada M, Kaneko K, Ohsugi M, Nakaya K, Terai A, Suzuki R, Koike M, Uchiyama Y, Kadowaki T, Ueki K.Author information Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan.AbstractA growing body of evidence has underlined the significance of endoplasmic reticulum (ER) stress in the pathogenesis of diabetes mellitus. ER oxidoreductin (ERO) 1β is a pancreas-specific disulfide oxidase that is known to be upregulated in response to ER stress and to promote protein folding in pancreatic β cells. It has recently been demonstrated that ERO1β promotes insulin biogenesis in β cells and thus contributes to physiological glucose homeostasis, though it is unknown if ERO1β is involved in the pathogenesis of diabetes mellitus. Here we show that in diabetic model mice ERO1β expression is paradoxically decreased in β cells despite the indications of increased ER stress. However, overexpression of ERO1β in β cells led to upregulation of unfolded protein response genes and markedly enlarged ER lumens, indicating that ERO1β overexpression caused ER stress in the β cells. Insulin contents were decreased in the β cells overexpressed with ERO1β, leading to impaired insulin secretion in response to glucose stimulation. These data indicate the importance of the fine-tuning of the ER redox state, the disturbance of which would compromise β cell function to synthesize insulin and thus contribute to the pathogenesis of diabetes mellitus.
  • Molecular and cellular biology.Mol Cell Biol.2014 Jan 27. [Epub ahead of print]
  • A growing body of evidence has underlined the significance of endoplasmic reticulum (ER) stress in the pathogenesis of diabetes mellitus. ER oxidoreductin (ERO) 1β is a pancreas-specific disulfide oxidase that is known to be upregulated in response to ER stress and to promote protein folding in pan
  • PMID 24469402

和文文献

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関連リンク

Metabolism is the process your body uses to get or make energy from the food you eat. Food is made up of proteins, carbohydrates and fats. Chemicals in your digestive system break the food parts down into sugars and acids, your body's fuel.
Inborn errors of metabolism comprise a large class of genetic diseases involving disorders of metabolism. The majority are due to defects of single genes that code for enzymes that facilitate conversion of various substances (substrates) into ...

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★リンクテーブル★
関連記事disturbance」「metabolic

disturbance」

  [★]

  • n.
  • 乱すこと、騒がすこと、撹乱。不安、心配。(医)障害
  • 騒動、動乱
  • 妨害、邪魔
anxietyanxiousanxiouslybarrierdamagederangementdifficultydiscomfortdisorderdisturbdysfunctiondysphoriafearfoehamperhindranceimpairimpairmentimpedeimpedimentinterceptinterceptioninterfereinterruptinterruptionlesionobstacleobstructocclusionperturbperturbationpreclusionuneasy

WordNet   license wordnet

「a disorderly outburst or tumult; "they were amazed by the furious disturbance they had caused"」
disruption, commotion, flutter, hurly burly, to-do, hoo-ha, hoo-hah, kerfuffle

WordNet   license wordnet

「an unhappy and worried mental state; "there was too much anger and disturbance"; "she didn''t realize the upset she caused me"」
perturbation, upset

WordNet   license wordnet

「the act of disturbing something or someone; setting something in motion」

PrepTutorEJDIC   license prepejdic

「〈U〉乱す(騒がす,妨害する)こと;乱れた状態 / 〈C〉騒ぎ,騒動,動乱 / 〈C〉乱す(騒がす,妨害する)もの」


metabolic」

  [★]

  • adj.
  • 代謝性の、代謝的な、メタボリックな
metabolically

WordNet   license wordnet

「of or relating to metabolism; "metabolic rate"」

PrepTutorEJDIC   license prepejdic

「新陳代謝の」

WordNet   license wordnet

「undergoing metamorphosis」
metabolous




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