metabolic bone disease

出典: meddic

bone metabolism disorderosteopenia

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/08/07 10:01:46」(JST)

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英文文献

  • Omic-profiling in breast cancer metastasis to bone: implications for mechanisms, biomarkers and treatment.
  • Wood SL, Westbrook JA, Brown JE.Author information Wolfson Molecular Imaging Centre, University of Manchester, Manchester M20 3LJ, UK. Electronic address: steven.wood@manchester.ac.uk.AbstractDespite well-recognised advances in breast cancer treatment, there remain substantial numbers of patients who develop metastatic disease, of which up to 70% involves spread to bone, resulting in skeletal complications which have a major negative impact on mortality and quality of life. Bisphosphonates and newer bone-targeted agents have reduced the prevalence of skeletal complications, yet there remains significant unmet clinical need, particularly for the development of more specific therapies for the prevention and treatment of metastatic bone disease, for the prediction of risk of its development in individual patients and for the prediction of response to treatments. Modern 'omic' strategies can potentially make a major contribution to meeting this need. Technological advances in the field of nucleic acid sequencing, mass spectrometry and metabolic profiling have driven progress in genomics, transcriptomics (functional genomics), proteomics and metabolomics. This review appraises the recent application of these approaches to studies of breast cancer metastasis (particularly to bone), with a focus on understanding how omic approaches may lead to new therapeutic options and to novel biomarker molecules or molecular signatures with potential value in clinical practise. The increasingly recognised need for rigorous sample quality control and both pre-clinical and clinical validation to meet the ultimate goals of clinical utility and patient benefit is discussed. Future directions of omic driven research in breast cancer metastasis are considered, in particular micro-RNAs and their role in the post-transcriptional regulation of gene function and the possible role of cancer-stem cells and epigenetic modifications in the development of distant metastases.
  • Cancer treatment reviews.Cancer Treat Rev.2014 Feb;40(1):139-52. doi: 10.1016/j.ctrv.2013.07.006. Epub 2013 Aug 16.
  • Despite well-recognised advances in breast cancer treatment, there remain substantial numbers of patients who develop metastatic disease, of which up to 70% involves spread to bone, resulting in skeletal complications which have a major negative impact on mortality and quality of life. Bisphosphonat
  • PMID 23958309
  • Two novel mutations in the SLCO2A1 gene in a Chinese patient with primary hypertrophic osteoarthropathy.
  • Zhang Z1, He JW2, Fu WZ2, Zhang CQ3, Zhang ZL4.Author information 1Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University Affiliated the Sixth People's Hospital, Shanghai 200233, 600 Yi-Shan Rd., PR China; Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated the Sixth People's Hospital, Shanghai 200233, 600 Yi-Shan Rd., PR China.2Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University Affiliated the Sixth People's Hospital, Shanghai 200233, 600 Yi-Shan Rd., PR China.3Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated the Sixth People's Hospital, Shanghai 200233, 600 Yi-Shan Rd., PR China.4Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University Affiliated the Sixth People's Hospital, Shanghai 200233, 600 Yi-Shan Rd., PR China. Electronic address: zzl2002@medmail.com.cn.AbstractPrimary hypertrophic osteoarthropathy (PHO) is a rare monogenetic disease characterized by digital clubbing, periostosis and pachydermia. Mutations in the 15-hydroxy-prostaglandin dehydrogenase (HPGD) gene and solute carrier organic anion transporter family member 2A1 (SLCO2A1) gene have been shown to be associated with PHO. Here, we described clinical characteristics in a Chinese patient with PHO, and identified two novel mutations in SLCO2A1: a heterozygous guanine-to-thymidine transition at the invariant -1 position of the acceptor site of intron 2 (c.235-1G>T) and a heterozygous missense mutation p.Pro219Leu (c.656C>T) in exon 5.
  • Gene.Gene.2014 Jan 25;534(2):421-3. doi: 10.1016/j.gene.2013.10.051. Epub 2013 Nov 1.
  • Primary hypertrophic osteoarthropathy (PHO) is a rare monogenetic disease characterized by digital clubbing, periostosis and pachydermia. Mutations in the 15-hydroxy-prostaglandin dehydrogenase (HPGD) gene and solute carrier organic anion transporter family member 2A1 (SLCO2A1) gene have been shown
  • PMID 24185079
  • Effects of clodronate and alendronate on osteoclast and osteoblast co-cultures on silk-hydroxyapatite films.
  • Hayden RS, Vollrath M, Kaplan DL.Author information Department of Biomedical Engineering, Tufts University, 4 Colby St., Medford, MA 02155, USA.AbstractThe goal of this study was to explore the effects of osteoporosis-related therapeutics on bone remodeling in vitro. A previously established bone-tissue mimetic system consisting of silk protein biomaterials in combination with hydroxyapatite and human cells was used for the study. Silk-hydroxyapatite films were pre-complexed with the non-nitrogenous bisphosphonate clodronate or the nitrogenous bisphosphonate alendronate and cultured with THP-1 human acute monocytic leukemia cell line-derived osteoclasts, human mesenchymal stem cell derived osteoblasts or a direct co-culture of the two cell types. Metabolic activity, calcium deposition and alkaline phosphatase activity were assessed over 12weeks, and reconstructed remodeled biomaterial surfaces were also evaluated for quantitative morphological changes. Increased metabolic activity and increased roughness were found on the clodronate-complexed biomaterial substrates remodeled by osteoblasts and co-cultures of osteoblasts with osteoclasts, even at doses high enough to cause a 90% decrease in osteoclast metabolic activity. Films complexed with low doses of alendronate resulted in increased metabolic activity and calcium deposition by osteoblasts, while higher doses were similarly toxic among osteoclasts, osteoblasts and co-cultures. These results point to the utility of these well-defined bone-mimetic in vitro cultures as useful screens for therapeutics for bone-related diseases, particularly with the ability to conduct studies for extended duration (here for 12weeks) and with pre-complexed drugs to mimic conditions found in vivo.
  • Acta biomaterialia.Acta Biomater.2014 Jan;10(1):486-93. doi: 10.1016/j.actbio.2013.09.028. Epub 2013 Oct 1.
  • The goal of this study was to explore the effects of osteoporosis-related therapeutics on bone remodeling in vitro. A previously established bone-tissue mimetic system consisting of silk protein biomaterials in combination with hydroxyapatite and human cells was used for the study. Silk-hydroxyapati
  • PMID 24096150

和文文献

  • 全身性疾患としての慢性腎臓病
  • 骨粗鬆症の危険因子としての慢性の精神的ストレス
  • 専門医試験をめざす症例問題トレーニング 代謝性骨疾患(骨粗鬆症を含む)

関連リンク

metabolic bone disease Any defect in bone absorption or deposition that alters the PTH/calcium-phosphate/vitamin D axis, often with increased bone fragility. Aetiology • Acquired—Fibrous dysplasia, Langerhans cell histiocytosis ...
For patients with stage 5 CKD who have low bone mineral density or fragility fractures, a double tetracycline-labeled bone biopsy is necessary to rule out other causes of metabolic bone disease and confirm a diagnosis of osteoporosis.

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★リンクテーブル★
リンク元骨代謝障害」「代謝性骨疾患」「bone metabolism disorder
拡張検索metabolic bone disease in premature infant
関連記事disease」「bone」「boned」「metabolic」「diseased

骨代謝障害」

  [★]

metabolic bone diseasebone metabolism disorder
代謝性骨疾患



代謝性骨疾患」

  [★]

metabolic bone disease
オステオペニア骨代謝障害


bone metabolism disorder」

  [★]

骨代謝障害

metabolic bone disease


metabolic bone disease in premature infant」

  [★] 未熟児代謝性骨疾患


disease」

  [★]

  • n.
疾患illnessより厳密な概念。「ある臓器に明確な障害が確認され、それによって症状が出ているとはっきり説明できる場合」 (PSY.9)
特定の原因、病態生理、症状、経過、予後、病理組織所見が全てそろった場合 (PSY.9)
  • something that is very wrong with people's attitudes, way of life or with society.
ailailmentdisease entitydisorderillillnessmaladysicksickness
  • 注意
diseaseillnessdisorder


WordNet   license wordnet

「an impairment of health or a condition of abnormal functioning」

PrepTutorEJDIC   license prepejdic

「(体の)『病気』,疾患 / (精神・道徳などの)病気,病弊」

PrepTutorEJDIC   license prepejdic

「女性の話術芸人 =diseur」


bone」

  [★]

WordNet   license wordnet

「remove the bones from; "bone the turkey before roasting it"」
debone

WordNet   license wordnet

「the porous calcified substance from which bones are made」
osseous tissue

WordNet   license wordnet

「consisting of or made up of bone; "a bony substance"; "the bony framework of the body"」

WordNet   license wordnet

「a shade of white the color of bleached bones」
ivory, pearl, off-white

WordNet   license wordnet

「rigid connective tissue that makes up the skeleton of vertebrates」
os

PrepTutorEJDIC   license prepejdic

「〈C〉骨 / 〈U〉骨を作っている物質,骨質 / 《複数形で》骨格;死骸(がい) / 〈魚など〉‘の'骨を取る」


boned」

  [★]

WordNet   license wordnet

「having bones as specified; "his lanky long-boned body"」

PrepTutorEJDIC   license prepejdic

「(魚など)骨を取り除いた / (衣服が)(コルセットなどで)骨で張りをつけた[ような]」

WordNet   license wordnet

「having had the bones removed; "a boneless rib roast"; "a boned (or deboned) fish"」
deboned


metabolic」

  [★]

  • adj.
  • 代謝性の、代謝的な、メタボリックな
metabolically

WordNet   license wordnet

「of or relating to metabolism; "metabolic rate"」

PrepTutorEJDIC   license prepejdic

「新陳代謝の」

WordNet   license wordnet

「undergoing metamorphosis」
metabolous

diseased」

  [★]

WordNet   license wordnet

「caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes"」
morbid, pathologic, pathological

PrepTutorEJDIC   license prepejdic

「病気にかかった / 病的な,不健全な(morbid)」




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