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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/29 01:19:46」(JST)
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Mestanolone
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| Systematic (IUPAC) name |
|
(5α,17β)-17-hydroxy-17-methylandrostan-3-one
|
| Clinical data |
| AHFS/Drugs.com |
International Drug Names |
Pregnancy
category |
|
| Legal status |
|
Routes of
administration |
Oral |
| Pharmacokinetic data |
| Bioavailability |
99% oral |
| Protein binding |
yes |
| Metabolism |
Hepatic |
| Biological half-life |
? |
| Excretion |
Renal |
| Identifiers |
| CAS Registry Number |
521-11-9 N |
| ATC code |
None |
| PubChem |
CID: 10633 |
| ChemSpider |
10187 Y |
| UNII |
S712YZ168E Y |
| KEGG |
D01533 Y |
| ChEMBL |
CHEMBL261514 Y |
| Synonyms |
(5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13,17-trimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-one |
| Chemical data |
| Formula |
C20H32O2 |
| Molecular mass |
304.467 g/mol |
SMILES
-
O=C2C[C@@H]1CC[C@@H]3[C@@H]([C@@]1(C)CC2)CC[C@]4([C@H]3CC[C@@]4(O)C)C
|
InChI
-
InChI=1S/C20H32O2/c1-18-9-6-14(21)12-13(18)4-5-15-16(18)7-10-19(2)17(15)8-11-20(19,3)22/h13,15-17,22H,4-12H2,1-3H3/t13-,15+,16-,17-,18-,19-,20-/m0/s1 Y
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Key:WYZDXEKUWRCKOB-YDSAWKJFSA-N Y
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| N (what is this?) (verify) |
Mestanolone is the 17α-methylated version of dihydrotestosterone (DHT).[1] The systematic name of mestanolone is: 17β-hydroxy-17α-methylandrost-3-one.[2] It is an orally bioavailable androgenic steroid that is highly androgenic while only slightly anabolic. It is incapable of aromatization and is not an agonist of the progesterone receptor.
Dosage Information
Dosages range from 10 mg to 30 mg a day for males. Women should avoid Mestanolone for it is very androgenic. Long term use, more than 12 weeks should be avoided do to hepatoxicity. Since Mestanolone is unable to convert to estrogen, it is very useful during cutting phases or when one wishes to avoid excess weight gain.
References
- ^ CTD (2007). "Chemicals: mestanolone". CTD - Comparative Toxicogenomics Database. Retrieved September 3, 2007.
- ^ Biology Online.org (2007). "mestanolone". Biology Online.org. Retrieved September 3, 2007.
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Anabolic steroids (A14)
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|
| Androstane (carbon 19 present) |
- Adrenosterone
- Androisoxazole
- Bolasterone (Myagen)
- Bolazine
- Boldione
- Boldenone undecylenate (Equipoise)
- 4-Chlordehydromethyltestosterone (Turinabol)
- 4-Hydroxytestosterone
- Calusterone
- Clostebol
- Danazol
- Desoxymethyltestosterone (Madol)
- DHT
- Drostanolone (Masteron)
- Enestebol
- Epitiostanol
- Fluoxymesterone (Halotestin)
- Formebolone
- Furazabol (Miotolan)
- Hydroxystenozole
- Mebolazine
- Mesabolone
- Mestanolone
- Mesterolone (Proviron)
- Methandriol
- Methandrostenolone (Dianabol)
- Metenolone
- Methenolone enanthate (Primobolan)
- Methasterone (Superdrol)
- Methyltestosterone
- Methyldiazirinol
- Oxandrolone (Anavar)
- Oxymetholone (Anadrol)
- Oxymesterone
- Prostanozol
- Quinbolone (Anabolicum Vister)
- Roxibolone
- Silandrone
- Stanozolol (Strombafort
- Winstrol)
- Stenbolone
- Testosterone`s (Sustamed
- Sustanon)
- 1-Testosterone
- Thiomesterone
|
|
| Estrene (carbon 19 absent) |
- Bolenol
- Ethyldienolone
- Ethylestrenol
- Mibolerone (Cheque Drops)
- Methylnortestosterone
- Metribolone (R1881)
- Nandrolone (Deca Durabolin)
- Norboletone (Genabol)
- Norclostebol
- Norethandrolone
- Normethandrone
- Oxabolone cipionate
- Propetandrol
- Tetrahydrogestrinone (The Clear)
- Trenbolone (Fina)
- Trestolone
|
|
| Prohormones |
- 1-Androstenediol
- 1,4-Androstadienedione
- 4-Androstenediol
- 4-Androstenedione
- 19-Norandrostenediol
- 19-Norandrostenedione
- DHEA
|
|
|
Index of digestion
|
|
| Description |
- Anatomy
- Physiology
- Development
|
|
| Disease |
- Congenital
- Neoplasms and cancer
- Inflammatory bowel disease
- Gluten sensitivity
- Other
- Symptoms and signs
- Blood tests
|
|
| Treatment |
- Procedures
- Drugs
- anabolic steroids
- antacids
- diarrhoea and infection
- bile and liver
- functional gastrointestinal disorders
- laxatives
- peptic ulcer and reflux
- nausea and vomiting
- other
- Surgery
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|
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Androgenics
|
|
Receptor
(ligands) |
|
AR
|
|
Agonists
|
|
|
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Mixed (SARMs)
|
- AC-262,356
- Andarine
- BMS-564,929
- Enobosarm
- LGD-2226
- LGD-3303
- LGD-4033
- S-23
- S-40503
- TFM-4AS-1
|
|
|
Antagonists
|
- 3α-Hydroxytibolone
- 3β-Hydroxytibolone
- Abiraterone
- Abiraterone acetate
- ARN-509
- Benorterone
- Bicalutamide
- BMS-641,988
- BOMT
- Canrenoic acid
- Canrenone
- Chlormadinone acetate
- Cimetidine
- Cioteronel
- Cyproterone
- Cyproterone acetate
- Delanterone
- Dienogest
- Drospirenone
- Enzalutamide
- Epitestosterone
- Flutamide
- Galeterone
- Hydroxyflutamide
- Inocoterone
- Ketoconazole
- Megestrol acetate
- Metogest
- Mifepristone
- Nilutamide
- Nomegestrol
- Nordinone
- Norgestimate
- Osaterone
- Oxendolone
- PF-998425
- Potassium canrenoate
- R2956
- Rosterolone
- RU-58642
- RU-58841
- Spironolactone
- Topilutamide (fluridil)
- Topterone
- Zanoterone
|
|
|
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| Enzyme |
|
Modulators
|
- 20,22-desmolase, 17α-hydroxylase/17,20-lyase, 3β-HSD, 17β-HSD, 5α-reductase, and aromatase) (see also Steroid hormone metabolism modulator)
|
|
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| Others |
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Precursors/prohormones
|
- Cholesterol
- 22R-Hydroxycholesterol
- 20α,22R-Dihydroxycholesterol
- Pregnenolone
- Pregnenolone sulfate
- 17-Hydroxypregnenolone
- Progesterone
- 17-Hydroxyprogesterone
- 11-Deoxycortisol (cortodoxone)
- DHEA
- DHEA sulfate
- 5-Androstenediol
- 4-Androstenedione
|
|
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Indirect
|
- Antigonadotropins (e.g., estrogens, progestogens, prolactin)
- GnRH agonists (e,g, GnRH, leuprorelin)
- GnRH antagonists (e.g., cetrorelix)
- Gonadotropins (e.g., FSH, hCG, LH)
- Kisspeptin
- Plasma proteins (ABP, albumin, SHBG)
|
|
|
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See also: Estrogenics • Glucocorticoids • Mineralocorticoids • Progestogenics
|
|
English Journal
- Electro-oxidation and voltammetric determination of oxymetholone in the presence of mestanolone using glassy carbon electrode modified with carbon nanotubes.
- Afkhami A, Ghaedi H, Madrakian T, Nematollahi D, Mokhtari B.
- Talanta. 2014 Apr;121()1-8.
- A new chemically modified electrode was constructed and applied to the electro-oxidation of the oxymetholone. Also, the electrode was applied to the simple, rapid, highly selective and sensitive determination of oxymetholone (OXM) in pharmaceutical and plasma samples using square wave voltammetry (S
- PMID 24607102
- Preconcentration and spectrophotometric determination of oxymetholone in the presence of its main metabolite (mestanolone) using modified maghemite nanoparticles in urine sample.
- Madrakian T, Afkhami A, Rahimi M, Ahmadi M, Soleimani M.
- Talanta. 2013 Oct;115()468-73.
- A novel and sensitive extraction procedure using maghemite nanoparticles (γ-Fe2O3) modified with sodium dodecyl sulfate (SDS), as an efficient solid phase, was developed for removal, preconcentration and spectrophotometric determination of trace amounts of oxymetholone (OXM), in the presence of mes
- PMID 24054620
- Effects of environmentally relevant concentrations of the xeno-androgen, methyldihydrotestosterone, on male and female mating behavior in Xenopus laevis.
- Hoffmann F, Kloas W.
- Chemosphere. 2012 Jun;87(11)1246-53.
- Endocrine disrupting compounds (EDCs) are well known to interfere with the hormone system of aquatic vertebrates and to affect their reproductive biology. 17α-Methyldihydrotestosterone (MDHT) is a widely used model compound for the assessment of androgenic EDCs, because it binds with high affinity
- PMID 22342339
Japanese Journal
- Simultaneous Doping Analysis of Main Urinary Metabolites of Anabolic Steroids in Horse by Ion-trap Gas Chromatography-Tandem Mass Spectrometry
- Efficient Oxidizing Methods for the Synthesis of Oxandrolone Intermediates
- Inhibitory Effect and Interaction of Stanozolol with Pig Testicular Cytochrome P-450 (17α-Hydroxylase/C_<17,20>-Lyase)
Related Links
- Ermalone is an altered version of dihydrotestosterone, DHT. An oral androgenic steroid, non-aromatizing Ermalone shares similarities with Winstrol and Anavar. ... Chemical Composition 17beta-hydroxy-17alpha-methyl-4-androsten-3 ...
- Mestanoloneとは？goo Wikipedia (ウィキペディア) 。出典：Wikipedia（ウィキペディア）フリー百科事典。 Mestanoloneとは - goo Wikipedia (ウィキペディア) gooトップ サイトマップ スタートページに設定 RSS ヘルプ メニューへスキップ ...
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